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- Publisher
- Springer Journals
- Copyright
- Copyright © 2005 by Nature Publishing Group
- Subject
- Biomedicine; Biomedicine, general; Cancer Research
- ISSN
- 1474-175X
- eISSN
- 1474-1768
- DOI
- 10.1038/nrc1590
- Publisher site
- See Article on Publisher Site
Abstract
Stem-cell populations have been identified in a range of haematopoietic and solid tumours, and might represent the cell of origin of these tumours. Normal and cancer stem cells express high levels of ATP-binding cassette (ABC) transporters, such as ABCB1, which encodes P-glycoprotein, and the half-transporter ABCG2, which was originally identified in mitoxantrone-resistant cells. The drug-transporting property of stem cells conferred by ABC transporters is the basis for the 'side-population' phenotype that arises from the exclusion of the fluorescent dye Hoechst 33342. Cancer stem cells are likely to share many of the properties of normal stem cells that provide for a long lifespan, including relative quiescence, resistance to drugs and toxins through the expression of several ABC transporters, an active DNA-repair capacity and a resistance to apoptosis. Therefore, tumours might have a built-in population of drug-resistant pluripotent cells that can survive chemotherapy and repopulate the tumour.
Journal
Nature Reviews Cancer – Springer Journals
Published: Apr 1, 2005