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Antiinflammatory peptides: current knowledge and promising prospects

Antiinflammatory peptides: current knowledge and promising prospects Background Inflammation is part of the regular host reaction to injury or infection caused by toxic factors, pathogens, dam- aged cells, irritants, and allergens. Antiinflammatory peptides (AIPs) are present in all living organisms, and many peptides from herbal, mammalian, bacterial, and marine origins have been shown to have antimicrobial and/or antiinflammatory properties. Methods In this study, we investigated the effects of antiinflammatory peptides on inflammation, and highlighted the under - lying mechanisms responsible for these effects. Results In multicellular organisms, including humans, AIPs constitute an essential part of their immune system. In addition, numerous natural and synthetic AIPs are effective immunomodulators and can interfere with signal transduction pathways involved in inflammatory cytokine expression. Among them, some peptides such as antiflammin, N-acetyl-seryl-aspartyl- lysyl-proline (Ac-SDKP), and those derived from velvet antler proteins, bee venom, horse fly salivary gland, and bovine β-casein have received considerable attention over the past few years. Conclusion This article presents an overview on the major properties and mechanisms of action associated with AIPs as immunomodulatory, chemotactic, antioxidant, and antimicrobial agents. In addition, the results of various studies dealing with effects of AIPs on numerous classical models of inflammation are reviewed and discussed. Keywords Inflammation · Antiinflammatory peptides · Health · http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Inflammation Research Springer Journals

Antiinflammatory peptides: current knowledge and promising prospects

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References (181)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Nature Switzerland AG
Subject
Biomedicine; Immunology; Pharmacology/Toxicology; Rheumatology; Allergology; Dermatology; Neurology
ISSN
1023-3830
eISSN
1420-908X
DOI
10.1007/s00011-018-1208-x
Publisher site
See Article on Publisher Site

Abstract

Background Inflammation is part of the regular host reaction to injury or infection caused by toxic factors, pathogens, dam- aged cells, irritants, and allergens. Antiinflammatory peptides (AIPs) are present in all living organisms, and many peptides from herbal, mammalian, bacterial, and marine origins have been shown to have antimicrobial and/or antiinflammatory properties. Methods In this study, we investigated the effects of antiinflammatory peptides on inflammation, and highlighted the under - lying mechanisms responsible for these effects. Results In multicellular organisms, including humans, AIPs constitute an essential part of their immune system. In addition, numerous natural and synthetic AIPs are effective immunomodulators and can interfere with signal transduction pathways involved in inflammatory cytokine expression. Among them, some peptides such as antiflammin, N-acetyl-seryl-aspartyl- lysyl-proline (Ac-SDKP), and those derived from velvet antler proteins, bee venom, horse fly salivary gland, and bovine β-casein have received considerable attention over the past few years. Conclusion This article presents an overview on the major properties and mechanisms of action associated with AIPs as immunomodulatory, chemotactic, antioxidant, and antimicrobial agents. In addition, the results of various studies dealing with effects of AIPs on numerous classical models of inflammation are reviewed and discussed. Keywords Inflammation · Antiinflammatory peptides · Health ·

Journal

Inflammation Research – Springer Journals

Published: Dec 17, 2018

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