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References (192)
-
Mark Anderson, Emily Venanzi, L. Klein, Zhibin Chen, S. Berzins, S. Turley, H. Boehmer, R. Bronson, A. Dierich, C. Benoist, D. Mathis (2002)
Projection of an Immunological Self Shadow Within the Thymus by the Aire ProteinScience, 298
-
Shenyuan Zhang, Ying Yu, J. Roos, J. Kozak, T. Deerinck, Mark Ellisman, K. Stauderman, M. Cahalan (2005)
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membraneNature, 437
-
Deyu Fang, Yun-Cai Liu (2001)
Proteolysis-independent regulation of PI3K by Cbl-b–mediated ubiquitination in T cellsNature Immunology, 2
-
N. Lineberry, L. Su, L. Soares, G. Fathman (2008)
The Single Subunit Transmembrane E3 Ligase Gene Related to Anergy in Lymphocytes (GRAIL) Captures and Then Ubiquitinates Transmembrane Proteins across the Cell Membrane*Journal of Biological Chemistry, 283
-
S. Feske, R. Draeger, H. Peter, K. Eichmann, A. Rao (2007)
The duration of nuclear residence of NFAT determines the pattern of cytokine expression in human SCID T cellsThe Journal of Immunology, 179
-
M. Kuhns, Mark Davis, K. Garcia (2006)
Deconstructing the form and function of the TCR/CD3 complex.Immunity, 24 2
-
H. Okamura, C. García-Rodríguez, H. Martinson, J. Qin, D. Virshup, A. Rao (2004)
A Conserved Docking Motif for CK1 Binding Controls the Nuclear Localization of NFAT1Molecular and Cellular Biology, 24
-
N. Harker, T. Naito, M. Cortés, A. Hostert, S. Hirschberg, M. Tolaini, K. Roderick, K. Georgopoulos, D. Kioussis (2002)
The CD8alpha gene locus is regulated by the Ikaros family of proteins.Molecular cell, 10 6
-
R. Greenwald, V. Boussiotis, R. Lorsbach, A. Abbas, A. Sharpe (2001)
CTLA-4 regulates induction of anergy in vivo.Immunity, 14 2
-
A. Ranger, M. Hodge, E. Gravallese, M. Oukka, L. Davidson, F. Alt, F. Brousse, T. Hoey, M. Grusby, L. Glimcher (1998)
Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc.Immunity, 8 1
-
J. Jain, Patricia McCafffrey, Z. Miner, T. Kerppola, J. Lambert, G. Verdine, T. Curran, A. Rao (1993)
The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and JunNature, 365
-
Yan Zheng, S. Collins, Michael Lutz, A. Allen, T. Kole, Paul Zarek, J. Powell (2007)
A Role for Mammalian Target of Rapamycin in Regulating T Cell Activation versus Anergy1The Journal of Immunology, 178
-
M. Šmída, Anita Posevitz-Fejfár, V. Hořejší, B. Schraven, J. Lindquist (2007)
A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation.Blood, 110 2
-
D. Mackenzie, J. Schartner, Jack Lin, A. Timmel, Martha Jennens-Clough, C. Fathman, C. Seroogy (2007)
GRAIL Is Up-regulated in CD4+ CD25+ T Regulatory Cells and Is Sufficient for Conversion of T Cells to a Regulatory Phenotype*Journal of Biological Chemistry, 282
-
S. Collins, Michael Lutz, Paul Zarek, R. Anders, G. Kersh, J. Powell (2008)
Opposing regulation of T cell function by Egr‐1/NAB2 and Egr‐2/Egr‐3European Journal of Immunology, 38
-
Pablo Arco, S. Martinez-Martinez, J. Maldonado, I. Ortega-Pérez, J. Redondo (2000)
A Role for the p38 MAP Kinase Pathway in the Nuclear Shuttling of NFATp*The Journal of Biological Chemistry, 275
-
U. Knippschild, A. Gocht, Sonja Wolff, Nadine Huber, J. Löhler, M. Stöter (2005)
The casein kinase 1 family: participation in multiple cellular processes in eukaryotes.Cellular signalling, 17 6
-
N. Lineberry, Leon Su, Jack Lin, Greg Coffey, C. Seroogy, C. Fathman (2008)
Cutting Edge: The Transmembrane E3 Ligase GRAIL Ubiquitinates the Costimulatory Molecule CD40 Ligand during the Induction of T Cell Anergy1The Journal of Immunology, 181
-
V. Heissmeyer, F. Macian, S. Im, R. Varma, S. Feske, K. Venuprasad, Hua Gu, Yun-Cai Liu, Michael Dustin, A. Rao (2004)
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteinsNature Immunology, 5
-
Le Trinh, R. Ferrini, B. Cobb, Amy Weinmann, K. Hahm, Patricia Ernst, I. Garraway, Matthias Merkenschlager, Stephen Smale (2001)
Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator.Genes & development, 15 14
-
M. Iacobelli, W. Wachsman, K. McGuire (2000)
Repression of IL-2 Promoter Activity by the Novel Basic Leucine Zipper p21SNFT Protein1 2The Journal of Immunology, 165
-
J. Bodor, J. Habener (1998)
Role of Transcriptional Repressor ICER in Cyclic AMP-mediated Attenuation of Cytokine Gene Expression in Human Thymocytes*The Journal of Biological Chemistry, 273
-
J. Rathmell, C. Thompson (1999)
The central effectors of cell death in the immune system.Annual review of immunology, 17
-
J. Falvo, Charles Lin, A. Tsytsykova, P. Hwang, D. Thanos, A. Goldfeld, T. Maniatis (2008)
A dimer-specific function of the transcription factor NFATpProceedings of the National Academy of Sciences, 105
-
M. Hundt, H. Tabata, Myung-Shin Jeon, Keitaro Hayashi, Yoshihiko Tanaka, Roma Krishna, Lauren Giorgio, Yun-Cai Liu, M. Fukata, A. Altman (2006)
Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect.Immunity, 24 5
-
B. Morgan, Lei Sun, N. Avitahl, K. Andrikopoulos, T. Ikeda, Ellen Gonzales, P. Wu, S. Neben, K. Georgopoulos (1997)
Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiationThe EMBO Journal, 16
-
M. Caetano, A. Vieira‐de‐Abreu, L. Teixeira, Miriam Werneck, M. Barcinski, J. Viola (2002)
NFATC2 transcription factor regulates cell cycle progression during lymphocyte activation: evidence of its involvement in the control of cyclin gene expressionThe FASEB Journal, 16
-
J. Koipally, K. Georgopoulos (2000)
Ikaros Interactions with CtBP Reveal a Repression Mechanism That Is Independent of Histone Deacetylase Activity*The Journal of Biological Chemistry, 275
-
H. Youn, T. Chatila, Jun Liu (2000)
Integration of calcineurin and MEF2 signals by the coactivator p300 during T‐cell apoptosisThe EMBO Journal, 19
-
O. Bueno, E. Brandt, M. Rothenberg, J. Molkentin (2002)
Defective T cell development and function in calcineurin A beta -deficient mice.Proceedings of the National Academy of Sciences of the United States of America, 99 14
-
Molnar (1994)
The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteinsMol Cell Biol, 14
-
R. Schwartz (2003)
T cell anergy.Annual review of immunology, 21
-
X. Bustelo, P. Crespo, M. López-Barahona, J. Gutkind, M. Barbacid (1997)
Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activationOncogene, 15
-
E. Wohlfert, M. Callahan, R. Clark (2004)
Resistance to CD4+CD25+ regulatory T cells and TGF-beta in Cbl-b-/- mice.Journal of immunology, 173 2
-
S. Feske, J. Giltnane, R. Dolmetsch, L. Staudt, A. Rao (2001)
Gene regulation mediated by calcium signals in T lymphocytesNature Immunology, 2
-
X. Zhong, R. Guo, Houde Zhou, Cheng-hu Liu, Chi-Keung Wan (2008)
Diacylglycerol kinases in immune cell function and self‐toleranceImmunological Reviews, 224
-
L. Su, N. Lineberry, Y. Huh, L. Soares, C. Fathman (2006)
A Novel E3 Ubiquitin Ligase Substrate Screen Identifies Rho Guanine Dissociation Inhibitor as a Substrate of Gene Related to Anergy in Lymphocytes1The Journal of Immunology, 177
-
A. Wiedemann, S. Müller, B. Favier, Doris Penna, M. Guiraud, C. Delmas, E. Champagne, S. Valitutti (2005)
T-cell activation is accompanied by an ubiquitination process occurring at the immunological synapse.Immunology letters, 98 1
-
Y. Kitaura, I. Jang, Yan Wang, Yoon-Chi Han, T. Inazu, Emily Cadera, M. Schlissel, R. Hardy, Hua Gu (2007)
Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b.Immunity, 26 5
-
Feske (2000)
The duration of nuclear residence of NFAT determines the pattern of cytokine expression in human SCID T cellsJ Immunol, 165
-
B. Kyewski, L. Klein (2006)
A central role for central tolerance.Annual review of immunology, 24
-
C. Chow, M. Rincón, J. Cavanagh, M. Dickens, R. Davis (1997)
Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway.Science, 278 5343
-
S. Bandyopadhyay, Noemí Soto-Nieves, F. Macian (2007)
Transcriptional regulation of T cell tolerance.Seminars in immunology, 19 3
-
B. Olenchock, R. Guo, J. Carpenter, M. Jordan, M. Topham, G. Koretzky, X. Zhong (2006)
Disruption of diacylglycerol metabolism impairs the induction of T cell anergyNature Immunology, 7
-
C. López-Rodríguez, J. Aramburu, A. Rakeman, A. Rao (1999)
NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun.Proceedings of the National Academy of Sciences of the United States of America, 96 13
-
R. Dolmetsch, R. Lewis, C. Goodnow, J. Healy (1997)
Differential activation of transcription factors induced by Ca2+ response amplitude and durationNature, 386
-
Andrew Chan, B. Irving, J. Fraser, Arthur Weiss (1991)
The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.Proceedings of the National Academy of Sciences of the United States of America, 88
-
C. Thien, R. Scaife, J. Papadimitriou, M. Murphy, D. Bowtell, W. Langdon (2003)
A Mouse with a Loss-of-function Mutation in the c-Cbl TKB Domain Shows Perturbed Thymocyte Signaling without Enhancing the Activity of the ZAP-70 Tyrosine KinaseThe Journal of Experimental Medicine, 197
-
J. Fontenot, M. Gavin, A. Rudensky (2003)
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsNature Immunology, 4
-
F. Macian, C. García-Rodríguez, A. Rao (2000)
Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and JunThe EMBO Journal, 19
-
C. Beals, Colleen Sheridan, C. Turck, Phyllis Gardner, G. Crabtree (1997)
Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3Science, 275
-
S. Feske, Y. Gwack, M. Prakriya, Sonal Srikanth, Sven-Holger Puppel, Bogdan Tanasa, P. Hogan, R. Lewis, M. Daly, A. Rao (2006)
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel functionNature, 441
-
Nancy Thornberry, Y. Lazebnik (1998)
Caspases: enemies within.Science, 281 5381
-
M. Murphy, Ralf Schnall, D. Venter, L. Barnett, I. Bertoncello, C. Thien, W. Langdon, D. Bowtell (1998)
Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient MiceMolecular and Cellular Biology, 18
-
R. Dolmetsch, Keli Xu, R. Lewis (1998)
Calcium oscillations increase the efficiency and specificity of gene expressionNature, 392
-
C. Seroogy, L. Soares, E. Ranheim, L. Su, C. Holness, D. Bloom, C. Fathman (2004)
The Gene Related to Anergy in Lymphocytes, an E3 Ubiquitin Ligase, Is Necessary for Anergy Induction in CD4 T Cells1The Journal of Immunology, 173
-
Opeyemi Olabisi, Noemí Soto-Nieves, E. Nieves, T. Yang, Xiaoyong Yang, R. Yu, Hee Suk, F. Macian, C. Chow (2008)
Regulation of Transcription Factor NFAT by ADP-RibosylationMolecular and Cellular Biology, 28
-
S. Bandyopadhyay, Myrianne Duré, Monika Paroder, Noemí Soto-Nieves, Irene Puga, F. Macian (2007)
Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells.Blood, 109 7
-
V. Boussiotis, D. Barber, Takayuki Nakarai, G. Freeman, John Gribben, Gregory Bernstein, Alan D’Andrea, Jerome Ritz, Lee Nadler (1994)
Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor.Science, 266 5187
-
R. Lewis (2001)
Calcium signaling mechanisms in T lymphocytes.Annual review of immunology, 19
-
D. Reynaud, Ignacio Demarco, K. Reddy, H. Schjerven, E. Bertolino, Zhengshan Chen, S. Smale, S. Winandy, Harinder Singh (2008)
Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by IkarosNature Immunology, 9
-
Jin-hong Wang, A. Nichogiannopoulou, Li Wu, Lei Sun, A. Sharpe, M. Bigby, K. Georgopoulos (1996)
Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation.Immunity, 5 6
-
D. Bates, Kristen Barthel, Yongqin Wu, Reza Kalhor, J. Stroud, M. Giffin, Lin Chen (2007)
Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element.Structure, 16 5
-
A. Alam, L. Cohen, Salah Aouad, R. Sékaly (1999)
Early Activation of Caspases during T Lymphocyte Stimulation Results in Selective Substrate Cleavage in Nonapoptotic CellsThe Journal of Experimental Medicine, 190
-
L. Soares, C. Seroogy, C. Seroogy, H. Skrenta, N. Anandasabapathy, Patricia Lovelace, C. Chung, E. Engleman, C. Fathman (2004)
Two isoforms of otubain 1 regulate T cell anergy via GRAILNature Immunology, 5
-
Jyothi Rengarajan, Betty Tang, L. Glimcher (2002)
NFATc2 and NFATc3 regulate TH2 differentiation and modulate TCR-responsiveness of naïve TH cellsNature Immunology, 3
-
A. Chan, M. Iwashima, C. Turck, A. Weiss (1992)
ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chainCell, 71
-
M. Gao, T. Labuda, Ying Xia, E. Gallagher, Deyu Fang, Yun-Cai Liu, M. Karin (2004)
Jun Turnover Is Controlled Through JNK-Dependent Phosphorylation of the E3 Ligase ItchScience, 306
-
N. Anandasabapathy, G. Ford, D. Bloom, C. Holness, V. Paragas, C. Seroogy, H. Skrenta, Marie Hollenhorst, C. Fathman, L. Soares (2003)
GRAIL : An E 3 Ubiquitin Ligase that Inhibits Cytokine Gene Transcription Is Expressed in Anergic CD 4 T Cells tumors -
Rut Valdor, V. Schreiber, Luis Sáenz, Teresa Martínez, Alba Muñoz‐Suano, M. Dominguez-Villar, P. Ramírez, P. Parrilla, E. Aguado, F. García-Cózar, J. Yélamos (2008)
Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells.Molecular immunology, 45 7
-
J. Arron, M. Winslow, A. Polleri, C. Chang, Hai-Ping Wu, Xin Gao, J. Neilson, Lei Chen, J. Heit, Seung Kim, Nobuyuki Yamasaki, T. Miyakawa, U. Francke, I. Graef, G. Crabtree (2006)
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21Nature, 441
-
F. Macian, C. López-Rodríguez, A. Rao (2001)
Partners in transcription: NFAT and AP-1Oncogene, 20
-
K. Georgopoulos, D. Moore, B. Derfler (1992)
Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment.Science, 258 5083
-
Lei Jin, P. Śliż, Lin Chen, F. Macian, A. Rao, P. Hogan, S. Harrison (2003)
An asymmetric NFAT1 dimer on a pseudo-palindromic κB-like DNA siteNature Structural Biology, 10
-
Hong-ying Wang, Yoav Altman, Deyu Fang, C. Elly, Yang Dai, Y. Shao, Yun-Cai Liu (2001)
Cbl Promotes Ubiquitination of the T Cell Receptor ζ through an Adaptor Function of Zap-70*The Journal of Biological Chemistry, 276
-
Lin Chen, J. Glover, P. Hogan, A. Rao, S. Harrison (1998)
Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNANature, 392
-
Dimuthu Desilva, W. Feeser, E. Tancula, Peggy Scherle (1996)
Anergic T cells are defective in both jun NH2-terminal kinase and mitogen-activated protein kinase signaling pathwaysThe Journal of Experimental Medicine, 183
-
A. Nayak, J. Glöckner-Pagel, M. Vaeth, J. Schumann, M. Buttmann, T. Bopp, E. Schmitt, E. Serfling, F. Berberich-Siebelt (2009)
Sumoylation of the Transcription Factor NFATc1 Leads to Its Subnuclear Relocalization and Interleukin-2 Repression by Histone Deacetylase*Journal of Biological Chemistry, 284
-
K. McGinnis, M. Gnegy, Yang Park, Neeta Mukerjee, Kevin Wang, Kevin Wang (1999)
Procaspase-3 and poly(ADP)ribose polymerase (PARP) are calpain substrates.Biochemical and biophysical research communications, 263 1
-
B. Olofsson (1999)
Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling.Cellular signalling, 11 8
-
A. Chan, M. Iwashima, C. Turck, A. Weiss (1992)
ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain.Cell, 71 4
-
Rajan Thomas, N. Chunder, Chunxia Chen, S. Umetsu, S. Winandy, A. Wells (2007)
Ikaros Enforces the Costimulatory Requirement for IL2 Gene Expression and Is Required for Anergy Induction in CD4+ T Lymphocytes1The Journal of Immunology, 179
-
K. Georgopoulos (2002)
Haematopoietic cell-fate decisions, chromatin regulation and ikarosNature Reviews Immunology, 2
-
David Telander, Erika-Nell Malvey, Daniel Mueller (1999)
Evidence for repression of IL-2 gene activation in anergic T cells.Journal of immunology, 162 3
-
J. Liou, Man Kim, W. Heo, Joshua Jones, J. Myers, J. Ferrell, T. Meyer (2005)
STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ InfluxCurrent Biology, 15
-
F. Shibasaki, U. Hallin, H. Uchino (2002)
Calcineurin as a multifunctional regulator.Journal of biochemistry, 131 1
-
A. Rao, C. Luo, P. Hogan (1997)
Transcription factors of the NFAT family: regulation and function.Annual review of immunology, 15
-
Fumihiko Tsushima, Sheng Yao, T. Shin, A. Flies, Sarah Flies, Haiying Xu, K. Tamada, D. Pardoll, Lieping Chen (2007)
Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy.Blood, 110 1
-
J. Aramburu, J. Heitman, G. Crabtree (2004)
Calcineurin: a central controller of signalling in eukaryotesEMBO reports, 5
-
J. Koipally, A. Renold, John Kim, K. Georgopoulos (1999)
Repression by Ikaros and Aiolos is mediated through histone deacetylase complexesThe EMBO Journal, 18
-
Min Zhuo, Wei Zhang, Hyeon Son, Isabelle Mansuy, Raymond Sobel, Jonathan Seidman, E. Kandel, E. Kandel (1999)
A selective role of calcineurin aalpha in synaptic depotentiation in hippocampus.Proceedings of the National Academy of Sciences of the United States of America, 96 8
-
Y. Chiang, H. Kole, K. Brown, M. Naramura, S. Fukuhara, R. Hu, I. Jang, J. Gutkind, E. Shevach, Hua Gu (2000)
Cbl-b regulates the CD28 dependence of T-cell activationNature, 403
-
Helen Keller, C. Garrison, Fathman, Neil Lineberry (2007)
Molecular mechanisms of CD4+ T-cell anergyNature Reviews Immunology, 7
-
S. Sakaguchi, Tomoyuki Yamaguchi, T. Nomura, M. Ono (2008)
Regulatory T Cells and Immune ToleranceCell, 133
-
V. Boussiotis, G. Freeman, A. Berezovskaya, D. Barber, L. Nadler (1997)
Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1.Science, 278 5335
-
O. Bueno, E. Brandt, M. Rothenberg, J. Molkentin (2002)
Defective T cell development and function in calcineurin Aβ-deficient miceProceedings of the National Academy of Sciences of the United States of America, 99
-
F. Chen, De-bin Huang, Yong-qing Chen, G. Ghosh (1998)
Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNANature, 391
-
M. Woo, R. Hakem, C. Furlonger, A. Hakem, G. Duncan, Takehiko Sasaki, D. Bouchard, Liwei Lu, Gillian Wu, C. Paige, T. Mak (2003)
Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificityNature Immunology, 4
-
S. Kitagawa-Sakakida, R. Schwartz (1996)
Multifactor cis-dominant negative regulation of IL-2 gene expression in anergized T cells.Journal of immunology, 157 6
-
H. Yoshida, H. Yoshida, H. Nishina, H. Nishina, H. Takimoto, H. Takimoto, L. Marengère, L. Marengère, A. Wakeham, A. Wakeham, D. Bouchard, D. Bouchard, Y. Kong, Y. Kong, T. Ohteki, A. Shahinian, A. Shahinian, M. Bachmann, P. Ohashi, J. Penninger, J. Penninger, G. Crabtree, T. Mak, T. Mak (1998)
The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production.Immunity, 8 1
-
A. Penna, A. Demuro, Andriy Yeromin, Shenyuan Zhang, O. Safrina, I. Parker, M. Cahalan (2008)
The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimersNature, 456
-
Yongqin Wu, M. Borde, V. Heissmeyer, M. Feuerer, A. Lapan, J. Stroud, D. Bates, Liang Guo, A. Han, S. Ziegler, D. Mathis, C. Benoist, Lin Chen, A. Rao (2006)
FOXP3 Controls Regulatory T Cell Function through Cooperation with NFATCell, 126
-
A. Allen, Yan Zheng, Lawrence Gardner, M. Safford, M. Horton, J. Powell (2004)
The Novel Cyclophilin Binding Compound, Sanglifehrin A, Disassociates G1 Cell Cycle Arrest from Tolerance Induction1The Journal of Immunology, 172
-
Lei Jin, P. Śliż, Lin Chen, F. Macian, A. Rao, P. Hogan, S. Harrison (2003)
An asymmetric NFAT1 dimer on a pseudo-palindromic kappa B-like DNA site.Nature structural biology, 10 10
-
P. Kim, Zhen-Yu Sun, S. Blacklow, G. Wagner, M. Eck (2003)
A Zinc Clasp Structure Tethers Lck to T Cell Coreceptors CD4 and CD8Science, 301
-
M. Jenkins, R. Schwartz (1987)
Antigen presentation by chemically modified splenocytes induces antigen- specific T cell unresponsiveness in vitro and in vivoThe Journal of Experimental Medicine, 165
-
L. Williams, A. Rudensky (2007)
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3Nature Immunology, 8
-
M. Naramura, I. Jang, H. Kole, Fang Huang, D. Haines, Hua Gu (2002)
c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulationNature Immunology, 3
-
Wei Li, C. Whaley, A. Mondino, D. Mueller (1996)
Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4+ T CellsScience, 271
-
C. Krawczyk, C. Krawczyk, K. Bachmaier, K. Bachmaier, Takehiko Sasaki, Takehiko Sasaki, Russell Jones, S. Snapper, D. Bouchard, I. Kozieradzki, I. Kozieradzki, P. Ohashi, F. Alt, J. Penninger, J. Penninger (2000)
Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells.Immunity, 13 4
-
K. Schuh, B. Kneitz, J. Heyer, U. Bommhardt, E. Jankevics, F. Berberich-Siebelt, K. Pfeffer, H. Müller-hermelink, A. Schimpl, E. Serfling (1998)
Retarded thymic involution and massive germinal center formation in NF‐ATp‐deficient miceEuropean Journal of Immunology, 28
-
Paul Zarek, Ching-Tai Huang, Eric Lutz, J. Kowalski, M. Horton, J. Linden, C. Drake, J. Powell (2008)
A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells.Blood, 111 1
-
V. Trouet, Jan Esper, Nicholas Graham, Andy Baker, J. Scourse, David, C. Frank (2002)
Supporting Online Material -
R. Thomas, S. Saouaf, A. Wells (2007)
Superantigen-induced CD4+ T cell tolerance is associated with DNA methylation and histone hypo-acetylation at cytokine gene lociGenes and Immunity, 8
-
Y. Zha, R. Marks, A. Ho, A. Peterson, Sujit Janardhan, I. Brown, K. Praveen, S. Stang, J. Stone, T. Gajewski (2006)
T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-αNature Immunology, 7
-
P. Hogan, Lin Chen, J. Nardone, A. Rao (2003)
Transcriptional regulation by calcium, calcineurin, and NFAT.Genes & development, 17 18
-
W. Perry, C. Hustad, D. Swing, T. O'Sullivan, N. Jenkins, N. Copeland (1998)
The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H miceNature Genetics, 18
-
Irene Puga, A. Rao, F. Macian (2008)
Targeted cleavage of signaling proteins by caspase 3 inhibits T cell receptor signaling in anergic T cells.Immunity, 29 2
-
K. Boatright, G. Salvesen (2003)
Mechanisms of caspase activation.Current opinion in cell biology, 15 6
-
M. Safford, S. Collins, Michael Lutz, A. Allen, Ching-Tai Huang, J. Kowalski, A. Blackford, M. Horton, C. Drake, R. Schwartz, J. Powell (2005)
Egr-2 and Egr-3 are negative regulators of T cell activationNature Immunology, 6
-
J. Koipally, J. Kim, B. Jones, A. Jackson, N. Avitahl, S. Winandy, M. Trevisan, A. Nichogiannopoulou, C. Kelley, K. Georgopoulos (1999)
Ikaros chromatin remodeling complexes in the control of differentiation of the hemo-lymphoid system.Cold Spring Harbor symposia on quantitative biology, 64
-
Myrianne Duré, F. Macian (2009)
IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes.Molecular immunology, 46 5
-
Jürgen Becker, T. Brabletz, Thomas Kirchner, C. Conrad, E. Bröcker, Ralph Reisfeld (1995)
Negative transcriptional regulation in anergic T cells.Proceedings of the National Academy of Sciences of the United States of America, 92 6
-
Myung-Shin Jeon, Alexandre Atfield, Alexandre Atfield, K. Venuprasad, C. Krawczyk, R. Sarao, R. Sarao, C. Elly, Chun Yang, S. Arya, S. Arya, K. Bachmaier, K. Bachmaier, L. Su, D. Bouchard, Russel Jones, M. Gronski, P. Ohashi, T. Wada, T. Wada, D. Bloom, C. Fathman, Yun-Cai Liu, J. Penninger, J. Penninger (2004)
Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.Immunity, 21 2
-
Á. Molnár, K. Georgopoulos (1994)
The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteinsMolecular and Cellular Biology, 14
-
Michael Dustin (2005)
A dynamic view of the immunological synapse.Seminars in immunology, 17 6
-
S. Baksh, H. Widlund, A. Frazer-Abel, Jinyan Du, S. Fosmire, D. Fisher, J. Decaprio, J. Modiano, S. Burakoff (2002)
NFATc2-mediated repression of cyclin-dependent kinase 4 expression.Molecular cell, 10 5
-
A. Mondino, D. Mueller (2007)
mTOR at the crossroads of T cell proliferation and tolerance.Seminars in immunology, 19 3
-
S. Ward, G. Hernandez-Hoyos, F. Chen, M. Waterman, R. Reeves, E. Rothenberg (1998)
Chromatin remodeling of the interleukin-2 gene: distinct alterations in the proximal versus distal enhancer regions.Nucleic acids research, 26 12
-
Y. Terui, Natalie Saad, S. Jia, F. McKeon, Junying Yuan (2004)
Dual Role of Sumoylation in the Nuclear Localization and Transcriptional Activation of NFAT1*Journal of Biological Chemistry, 279
-
O. Avni, Dong Lee, F. Macian, S. Szabo, L. Glimcher, A. Rao (2002)
TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genesNature Immunology, 3
-
Kym Duncliffe, A. Bert, M. Vadas, P. Cockerill (1997)
A T cell-specific enhancer in the interleukin-3 locus is activated cooperatively by Oct and NFAT elements within a DNase I-hypersensitive site.Immunity, 6 2
-
John Kim, Sa¨ıd Sif, B. Jones, Audrey Jackson, J. Koipally, Elizabeth Heller, S. Winandy, A. Viel, A. Sawyer, Toru Ikeda, R. Kingston, K. Georgopoulos (1999)
Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.Immunity, 10 3
-
B. Fife, J. Bluestone (2008)
Control of peripheral T‐cell tolerance and autoimmunity via the CTLA‐4 and PD‐1 pathwaysImmunological Reviews, 224
-
O. Lechner, J. Lauber, A. Franzke, A. Sarukhan, H. Boehmer, J. Buer (2001)
Fingerprints of anergic T cellsCurrent Biology, 11
-
S. Colombetti, F. Benigni, V. Basso, A. Mondino (2002)
Clonal Anergy Is Maintained Independently of T Cell Proliferation1The Journal of Immunology, 169
-
G. Crabtree, E. Olson (2002)
NFAT Signaling Choreographing the Social Lives of CellsCell, 109
-
J. Yoder, C. Pham, Y. Iizuka, O. Kanagawa, Stanley Liu, J. Mcglade, A. Cheng (2001)
Requirement for the SLP-76 Adaptor GADS in T Cell DevelopmentScience, 291
-
Noah Isakov, R. Wange, W. Burgess, J. Watts, Ruedi Aebersold, L. Samelson (1995)
ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinityThe Journal of Experimental Medicine, 181
-
M. Giffin, J. Stroud, D. Bates, Konstanze Koenig, J. Hardin, Lin Chen (2003)
Structure of NFAT1 bound as a dimer to the HIV-1 LTR kappa B element.Nature structural biology, 10 10
-
Ann Ranger, Mohamed Oukka, Jyothi Rengarajan, Laurie Glimcher (1998)
Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.Immunity, 9 5
-
X. Yang, Li Wang, Taosheng Chen, D. Hodge, J. Resau, L. DaSilva, W. Farrar (2000)
Activation of Human T Lymphocytes Is Inhibited by Peroxisome Proliferator-activated Receptor γ (PPARγ) AgonistsThe Journal of Biological Chemistry, 275
-
M. Vig, C. Peinelt, A. Beck, D. Koomoa, D. Rabah, M. Koblan-Huberson, S. Kraft, Helen Turner, A. Fleig, R. Penner, J. Kinet (2006)
CRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca2+ EntryScience, 312
-
Wei Ji, P. Xu, Zhengzheng Li, Jingze Lu, Lin Liu, Yi Zhan, Yu Chen, B. Hille, Tao Xu, Liangyi Chen (2008)
Functional stoichiometry of the unitary calcium-release-activated calcium channelProceedings of the National Academy of Sciences, 105
-
N. Anandasabapathy, G. Ford, D. Bloom, C. Holness, V. Paragas, C. Seroogy, H. Skrenta, Marie Hollenhorst, C. Fathman, L. Soares (2003)
GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells.Immunity, 18 4
-
M. Hodge, A. Ranger, F. Brousse, T. Hoey, M. Grusby, L. Glimcher (1996)
Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice.Immunity, 4 4
-
Hori (2003)
Control of regulatory T cell development by the transcription factor Foxp3Science, 299
-
K. Hahm, B. Cobb, Aaron McCarty, K. Brown, C. Klug, R. Lee, Koichi Akashi, I. Weissman, A. Fisher, S. Smale (1998)
Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin.Genes & development, 12 6
-
J. Liou, W. Heo, Joshua Jones, J. Myers, J. Ferrell, T. Meyer (2005)
STIM Is a Ca 2+ Sensor Essential for Ca 2+ -Store-Depletion-Triggered Ca 2+ Influx -
C. Thien, Frøydis Blystad, Y. Zhan, A. Lew, V. Voigt, C. Andoniou, W. Langdon (2005)
Loss of c‐Cbl RING finger function results in high‐intensity TCR signaling and thymic deletionThe EMBO Journal, 24
-
Jiangyu Zhu, F. Shibasaki, R. Price, J. Guillemot, T. Yano, V. Dötsch, G. Wagner, P. Ferrara, F. McKeon (1998)
Intramolecular Masking of Nuclear Import Signal on NF-AT4 by Casein Kinase I and MEKK1Cell, 93
-
Qi-jing Li, A. Dinner, S. Qi, D. Irvine, J. Huppa, Mark Davis, A. Chakraborty (2004)
CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapseNature Immunology, 5
-
Shenyuan Zhang, Andriy Yeromin, Xiang-Hong Zhang, Ying Yu, O. Safrina, A. Penna, J. Roos, K. Stauderman, M. Cahalan (2006)
Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity.Proceedings of the National Academy of Sciences of the United States of America, 103 24
-
V. Chan, C. Wong, P. Ohashi (2002)
Calcineurin Aα plays an exclusive role in TCR signaling in mature but not in immature T cellsEuropean Journal of Immunology, 32
-
Rajan Thomas, Ling Gao, A. Wells (2005)
Signals from CD28 Induce Stable Epigenetic Modification of the IL-2 Promoter1The Journal of Immunology, 174
-
Adrian McCollum, P. Nasr, S. Estus (2002)
Calpain activates caspase‐3 during UV‐induced neuronal death but only calpain is necessary for deathJournal of Neurochemistry, 82
-
C. Klee, Hao Ren, Xutong Wang (1998)
Regulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin*The Journal of Biological Chemistry, 273
-
Noemí Soto-Nieves, Irene Puga, Brian Abe, S. Bandyopadhyay, Ian Baine, A. Rao, F. Macian (2009)
Transcriptional complexes formed by NFAT dimers regulate the induction of T cell toleranceThe Journal of Experimental Medicine, 206
-
Dominique Davidson, B. Schraven, A. Veillette (2007)
PAG-Associated FynT Regulates Calcium Signaling and Promotes Anergy in T LymphocytesMolecular and Cellular Biology, 27
-
J. Roos, P. Digregorio, Andriy Yeromin, K. Ohlsen, M. Lioudyno, Shenyuan Zhang, O. Safrina, J. Kozak, S. Wagner, M. Cahalan, G. Velicelebi, K. Stauderman (2005)
STIM1, an essential and conserved component of store-operated Ca2+ channel functionThe Journal of Cell Biology, 169
-
T. Yang, C. Chow (2003)
Transcription Cooperation by NFAT·C/EBP Composite Enhancer Complex*The Journal of Biological Chemistry, 278
-
S. Xanthoudakis, J. Viola, K. Shaw, C. Luo, J. Wallace, P. Bozza, T. Curran, A. Rao (1996)
An Enhanced Immune Response in Mice Lacking the Transcription Factor NFAT1Science, 272
-
A. Willingham, A. Orth, S. Batalov, E. Peters, B. Wen, P. Aza‐Blanc, J. Hogenesch, Peter Schultz, P. Schultz (2005)
A Strategy for Probing the Function of Noncoding RNAs Finds a Repressor of NFATScience, 309
-
D. Hu, L. Ausubel, A. Abbas, B. Knoechel, Jens Lohr, Shirley Zhu, L. Wong (2006)
Functional and Molecular Comparison of Anergic and Regulatory T Lymphocytes -
Keane Mm, O. Rivero-Lezcano, Mitchell Ja, Keith Robbins, S. Lipkowitz (1995)
Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene.Oncogene, 10 12
-
T. Bopp, A. Palmetshofer, E. Serfling, V. Heib, S. Schmitt, Christoph Richter, M. Klein, H. Schild, E. Schmitt, M. Stassen (2005)
NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cellsThe Journal of Experimental Medicine, 201
-
M. Krogsgaard, J. Huppa, M. Purbhoo, Mark Davis (2003)
Linking molecular and cellular events in T-cell activation and synapse formation.Seminars in immunology, 15 6
-
V. Heissmeyer, F. Macian, R. Varma, S. Im, F. García-Cózar, H. Horton, M. Byrne, S. Feske, K. Venuprasad, Hua Gu, Yun-Cai Liu, Michael Dustin, A. Rao (2005)
A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling.Novartis Foundation symposium, 267
-
Y. Gwack, Sonia Sharma, J. Nardone, Bogdan Tanasa, A. Iuga, Sonal Srikanth, H. Okamura, D. Bolton, S. Feske, P. Hogan, A. Rao (2006)
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFATNature, 441
-
J. Jain, P. Mccaffrey, V. Valge-Archer, A. Rao (1992)
Nuclear factor of activated T cells contains Fos and JunNature, 356
-
J. Harris, K. Bishop, N. Phillips, J. Mordes, D. Greiner, A. Rossini, M. Czech (2004)
Early Growth Response Gene-2, a Zinc-Finger Transcription Factor, Is Required for Full Induction of Clonal Anergy in CD4+ T Cells1The Journal of Immunology, 173
-
B. Cobb, Susana Morales-Alcelay, Gary Kleiger, Karen Brown, Amanda Fisher, S. Smale (2000)
Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding.Genes & development, 14 17
-
X. Yang, L. Wang, T. Chen, D. Hodge, J. Resau, L. DaSilva, W. Farrar (2000)
Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPARgamma co-association with transcription factor NFAT.The Journal of biological chemistry, 275 7
-
F. Macian, S. Im, F. García-Cózar, A. Rao (2004)
T-cell anergy.Current opinion in immunology, 16 2
-
Wen-hong Li, J. Llopis, M. Whitney, G. Zlokarnik, R. Tsien (1998)
Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expressionNature, 392
-
Yujun Zhang, D. Center, D. Wu, W. Cruikshank, Junying Yuan, D. Andrews, H. Kornfeld (1998)
Processing and Activation of Pro-Interleukin-16 by Caspase-3*The Journal of Biological Chemistry, 273
-
Lequn Li, Y. Iwamoto, A. Berezovskaya, V. Boussiotis (2006)
A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell toleranceNature Immunology, 7
-
N. Harker, T. Naito, M. Cortés, A. Hostert, S. Hirschberg, M. Tolaini, K. Roderick, K. Georgopoulos, D. Kioussis (2002)
The CD8α Gene Locus Is Regulated by the Ikaros Family of ProteinsMolecular Cell, 10
-
L. Santambrogio, I. Potolicchio, S. Fessler, S. Wong, G. Raposo, J. Strominger (2005)
Involvement of caspase-cleaved and intact adaptor protein 1 complex in endosomal remodeling in maturing dendritic cellsNature Immunology, 6
-
M. Naramura, H. Kole, R. Hu, Hua Gu (1998)
Altered thymic positive selection and intracellular signals in Cbl-deficient mice.Proceedings of the National Academy of Sciences of the United States of America, 95 26
-
Mohamed Oukka, I-Cheng Ho, F. Brousse, Timothy Hoey, M. Grusby, Laurie Glimcher (1998)
The transcription factor NFAT4 is involved in the generation and survival of T cells.Immunity, 9 3
-
S. Peng, Andrea Gerth, A. Ranger, L. Glimcher (2001)
NFATc1 and NFATc2 together control both T and B cell activation and differentiation.Immunity, 14 1
-
M. Oh‐hora, Megumi Yamashita, P. Hogan, Sonia Sharma, E. Lamperti, Woo-Chan Chung, M. Prakriya, S. Feske, A. Rao (2008)
Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and toleranceNature Immunology, 9
-
J. Stroud, Lin Chen (2003)
Structure of NFAT bound to DNA as a monomer.Journal of molecular biology, 334 5
-
F. Macian, F. García-Cózar, S. Im, H. Horton, M. Byrne, A. Rao (2002)
Transcriptional Mechanisms Underlying Lymphocyte ToleranceCell, 109
-
Jyothi Rengarajan, K. Mowen, K. McBride, Erica Smith, Harinder Singh, L. Glimcher (2002)
Interferon Regulatory Factor 4 (IRF4) Interacts with NFATc2 to Modulate Interleukin 4 Gene ExpressionThe Journal of Experimental Medicine, 195
-
H. Okamura, J. Aramburu, C. García-Rodríguez, J. Viola, Anuradha Raghavan, Mamta Tahiliani, Xiaolong Zhang, J. Qin, P. Hogan, A. Rao (2000)
Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity.Molecular cell, 6 3
-
P. Fields, T. Gajewski, F. Fitch (1996)
Blocked Ras Activation in Anergic CD4+ T CellsScience, 271
-
K. Bachmaier, C. Krawczyk, I. Kozieradzki, Y. Kong, Takehiko Sasaki, A. Oliveira-dos-Santos, S. Mariathasan, D. Bouchard, A. Wakeham, A. Itié, J. Le, P. Ohashi, I. Sarosi, H. Nishina, S. Lipkowitz, J. Penninger (2000)
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-bNature, 403
-
E. Wohlfert, M. Callahan, R. Clark (2004)
Resistance to CD4+CD25+ Regulatory T Cells and TGF-β in Cbl-b−/− MiceThe Journal of Immunology, 173
-
H. Quill, R. Schwartz (1987)
Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness.Journal of immunology, 138 11
-
Alexander Kiani, J. Viola, A. Lichtman, A. Rao (1997)
Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1.Immunity, 7 6
- Publisher
- Wiley
- Copyright
- Copyright © 2009 Wiley Subscription Services
- ISSN
- 0105-2896
- eISSN
- 1600-065X
- DOI
- 10.1111/j.1600-065X.2009.00817.x
- pmid
- 19754900
- Publisher site
- See Article on Publisher Site
Abstract
Summary: Cells that escape negative selection in the thymus must be inactivated or eliminated in the periphery through a series of mechanisms that include the induction of anergy, dominant suppression by regulatory T cells, and peripheral deletion of self‐reactive T cells. Calcium signaling plays a central role in the induction of anergy in T cells, which become functionally inactivated and incapable of proliferating and expressing cytokines following antigen re‐encounter. Suboptimal stimulation of T cells results in the activation of a calcium/calcineurin/nuclear factor of activated T cells‐dependent cell‐intrinsic program of self‐inactivation. The proteins encoded by those genes are required to impose a state of functional unresponsiveness through different mechanisms that include downregulation of T‐cell receptor signaling and inhibition of cytokine transcription.
Journal
Immunological Reviews – Wiley
Published: Jan 1, 2009
Keywords: ; ; ; ;