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Measurement of current‐voltage relations in the membrane of the giant axon of Loligo

Measurement of current‐voltage relations in the membrane of the giant axon of Loligo i6, J. Physiol. (I952) 424-448 MEASUREMENT OF CURRENT-VOLTAGE RELATIONS IN THE MEMBRANE OF THE GIANT AXON OF LOLIGO BY A. L. AND HODGKIN, A. F. HUX-LEY B. 1KATZ From the Laboratory of the Marine Biological Association, Plymouth, and the Physiological Laboratory, University of Cambridge (Received 24 October 1951) The importance of ionic movements in excitable tissues has been emphasized by a number of recent experiments. On is the the one hand, there finding that the nervous impulse is associated with an inflow of sodium and an outflow of potassiuim (e.g. Rothenberg, 1950; Keynes & Lewis, On the 1951). other, there are experiments which show that the rate of and rise amplitude of the action potential are determined by the concentration of sodium in the external medium (e.g. Hodgkin & Katz, 1949 a; Huxley & Stiimpffi, 1951). Both groups of experiments are consistent with the theory that nervous conduction depends on a specific increase in permeability which allows sodium ions to move from the more concentrated solution outside a nerve fibre to the more dilute inside it. This movement of solution charge makes the inside of the fibre positive and provides a satisfactory explanation for the rising phase of the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Physiology Wiley

Measurement of current‐voltage relations in the membrane of the giant axon of Loligo

Hodgkin, A. L.; Huxley, A. F.; Katz, B.
The Journal of Physiology , Volume 116 (4) – Jan 28, 1952
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References (17)

Publisher
Wiley
Copyright
© 2014 The Physiological Society
ISSN
0022-3751
eISSN
1469-7793
DOI
10.1113/jphysiol.1952.sp004716
Publisher site
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Abstract

i6, J. Physiol. (I952) 424-448 MEASUREMENT OF CURRENT-VOLTAGE RELATIONS IN THE MEMBRANE OF THE GIANT AXON OF LOLIGO BY A. L. AND HODGKIN, A. F. HUX-LEY B. 1KATZ From the Laboratory of the Marine Biological Association, Plymouth, and the Physiological Laboratory, University of Cambridge (Received 24 October 1951) The importance of ionic movements in excitable tissues has been emphasized by a number of recent experiments. On is the the one hand, there finding that the nervous impulse is associated with an inflow of sodium and an outflow of potassiuim (e.g. Rothenberg, 1950; Keynes & Lewis, On the 1951). other, there are experiments which show that the rate of and rise amplitude of the action potential are determined by the concentration of sodium in the external medium (e.g. Hodgkin & Katz, 1949 a; Huxley & Stiimpffi, 1951). Both groups of experiments are consistent with the theory that nervous conduction depends on a specific increase in permeability which allows sodium ions to move from the more concentrated solution outside a nerve fibre to the more dilute inside it. This movement of solution charge makes the inside of the fibre positive and provides a satisfactory explanation for the rising phase of the

Journal

The Journal of Physiology – Wiley

Published: Jan 28, 1952

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