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Resting and action potentials in single nerve fibres

Resting and action potentials in single nerve fibres J. Physiol. I04, I76-I95 6I2.8I6 (I945) RESTING AND ACTION POTENTIALS IN SINGLE NERVE FIBRES BY A. L. HODGKIN AND A. F. HUXLEY From the Physiological and the Laboratory, Cambridge, Laboratory of the Marine Biological Association, Plymouth (Received 20 February 1945) the action Until recently of nerve and muscle has been potential to thought arise from a transient breakdown of the cell membrane. This polarized hypo- thesis was widely as an of the membrane accepted integral part of theory nervous it rested little more than a activity, although upon rough equality in the of apparent magnitudes action and in resting potentials. Early we made an to check the attempt the relative hypothesis by comparing of action and magnitudes in a nerve resting potentials fibre. We ex- single pected to find that the would be resting potential than slightly the larger action potential, since it was known that the membrane resistance has finite though small value during & activity (Cole Curtis, 1939). Instead of the result we found the expected action to be potential much than larger the The resting potential. first measurements were made with crustacean axons and external but were electrodes, not completely satisfactory because they not the did http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Physiology Wiley

Resting and action potentials in single nerve fibres

Hodgkin, A. L.; Huxley, A. F.
The Journal of Physiology , Volume 104 (2) – Jan 15, 1945
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References (2)

Publisher
Wiley
Copyright
© 2014 The Physiological Society
ISSN
0022-3751
eISSN
1469-7793
DOI
10.1113/jphysiol.1945.sp004114
Publisher site
See Article on Publisher Site

Abstract

J. Physiol. I04, I76-I95 6I2.8I6 (I945) RESTING AND ACTION POTENTIALS IN SINGLE NERVE FIBRES BY A. L. HODGKIN AND A. F. HUXLEY From the Physiological and the Laboratory, Cambridge, Laboratory of the Marine Biological Association, Plymouth (Received 20 February 1945) the action Until recently of nerve and muscle has been potential to thought arise from a transient breakdown of the cell membrane. This polarized hypo- thesis was widely as an of the membrane accepted integral part of theory nervous it rested little more than a activity, although upon rough equality in the of apparent magnitudes action and in resting potentials. Early we made an to check the attempt the relative hypothesis by comparing of action and magnitudes in a nerve resting potentials fibre. We ex- single pected to find that the would be resting potential than slightly the larger action potential, since it was known that the membrane resistance has finite though small value during & activity (Cole Curtis, 1939). Instead of the result we found the expected action to be potential much than larger the The resting potential. first measurements were made with crustacean axons and external but were electrodes, not completely satisfactory because they not the did

Journal

The Journal of Physiology – Wiley

Published: Jan 15, 1945

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