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- Publisher
- Springer Journals
- Copyright
- Copyright © 2009 by Macmillan Publishers Limited. All rights reserved
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/nature07965
- Publisher site
- See Article on Publisher Site
Abstract
Immunocompromised individuals are at high risk from fungal infection, yet the molecular mechanisms that govern host defence against fungi are not well understood. Gross et al. now show that Candida albicans infection in mice activates the NALP3 inflammasome via a mechanism involving Sky-induced production of reactive oxygen induced by the tyrosine kinase Syk.
Journal
Nature – Springer Journals
Published: Apr 1, 2009