Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Endogenous Interleukin (IL)–1α and IL-1β Are Crucial for Host Defense against Disseminated Candidiasis

Endogenous Interleukin (IL)–1α and IL-1β Are Crucial for Host Defense against Disseminated... BackgroundInterleukin (IL)–1α and IL-1β are protective proinflammatory cytokines involved in host defense against Candida albicans. It is, however, unknown whether they provide protection through similar mechanisms. We investigated the effect of endogenous IL-1α and IL-1β on disseminated C. albicans infectionMethodsMice deficient in the genes encoding IL-1α (IL-1α−/−), IL-1β (IL-1β−/−), or both molecules (IL-1α−/−β−/−) were used. Survival and C. albicans outgrowth in the kidneys was assessed after intravenous injection of C. albicansResultsBoth mortality and C. albicans outgrowth in the kidneys were significantly increased in IL-1α−/− and IL-1β−/− mice, compared with those in control mice, with the IL-1α−/−β−/− mice being most susceptible to disseminated candidiasis. The host defense mechanisms triggered by IL-1α and IL-1β differed from one another. IL-1β−/− mice showed decreased recruitment of granulocytes in response to an intraperitoneal C. albicans challenge, and generation of superoxide production was diminished in IL-1β−/− granulocytes. IL-1α−/− mice had a reduced capacity to damage C. albicans pseudohyphae. Protective type 1 responses were deficient in both IL-1α−/− and IL-1β−/− mice, as assessed by production of interferon-γ by splenocytes in response to heat-killed C. albicansConclusionAlthough IL-1α and IL-1β have differential effects on the various arms of host defense, both cytokines are essential for mounting a protective host response against invasive C. albicans infection http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Infectious Diseases Oxford University Press

Endogenous Interleukin (IL)–1α and IL-1β Are Crucial for Host Defense against Disseminated Candidiasis

Download PDF
8 pages

Loading next page...
 
/lp/oxford-university-press/endogenous-interleukin-il-1-and-il-1-are-crucial-for-host-defense-wXQRfb7Axc

References (30)

Publisher
Oxford University Press
Copyright
© Published by Oxford University Press.
Subject
Major Article
ISSN
0022-1899
eISSN
1537-6613
DOI
10.1086/503363
pmid
16619190
Publisher site
See Article on Publisher Site

Abstract

BackgroundInterleukin (IL)–1α and IL-1β are protective proinflammatory cytokines involved in host defense against Candida albicans. It is, however, unknown whether they provide protection through similar mechanisms. We investigated the effect of endogenous IL-1α and IL-1β on disseminated C. albicans infectionMethodsMice deficient in the genes encoding IL-1α (IL-1α−/−), IL-1β (IL-1β−/−), or both molecules (IL-1α−/−β−/−) were used. Survival and C. albicans outgrowth in the kidneys was assessed after intravenous injection of C. albicansResultsBoth mortality and C. albicans outgrowth in the kidneys were significantly increased in IL-1α−/− and IL-1β−/− mice, compared with those in control mice, with the IL-1α−/−β−/− mice being most susceptible to disseminated candidiasis. The host defense mechanisms triggered by IL-1α and IL-1β differed from one another. IL-1β−/− mice showed decreased recruitment of granulocytes in response to an intraperitoneal C. albicans challenge, and generation of superoxide production was diminished in IL-1β−/− granulocytes. IL-1α−/− mice had a reduced capacity to damage C. albicans pseudohyphae. Protective type 1 responses were deficient in both IL-1α−/− and IL-1β−/− mice, as assessed by production of interferon-γ by splenocytes in response to heat-killed C. albicansConclusionAlthough IL-1α and IL-1β have differential effects on the various arms of host defense, both cytokines are essential for mounting a protective host response against invasive C. albicans infection

Journal

Journal of Infectious Diseases – Oxford University Press

Published: May 15, 2006

There are no references for this article.