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Genome guardian p53 and viral infections

Genome guardian p53 and viral infections SUMMARY Because virus infections elicit various cellular responses that inhibit viral replication and growth, viruses must intervene to attenuate antiviral measures in order to thrive. The genome guardian p53 plays a central part not only in DNA damage responses, inducing cell cycle arrest or apoptosis, but also in the innate host immune control of viral infections by orchestrating diverse signaling pathways originating from many different cellular receptors and sensors. Many viruses have acquired sophisticated mechanisms to regulate p53 functions by deploying subversive proteins and modulating its post‐transcriptional status. In this review, we overview the mechanisms by which DNA and RNA viruses manage p53 signaling in favor of their continued survival. Copyright © 2012 John Wiley & Sons, Ltd. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reviews in Medical Virology Wiley

Genome guardian p53 and viral infections

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References (80)

Publisher
Wiley
Copyright
Copyright © 2013 John Wiley & Sons, Ltd.
ISSN
1052-9276
eISSN
1099-1654
DOI
10.1002/rmv.1738
pmid
23255396
Publisher site
See Article on Publisher Site

Abstract

SUMMARY Because virus infections elicit various cellular responses that inhibit viral replication and growth, viruses must intervene to attenuate antiviral measures in order to thrive. The genome guardian p53 plays a central part not only in DNA damage responses, inducing cell cycle arrest or apoptosis, but also in the innate host immune control of viral infections by orchestrating diverse signaling pathways originating from many different cellular receptors and sensors. Many viruses have acquired sophisticated mechanisms to regulate p53 functions by deploying subversive proteins and modulating its post‐transcriptional status. In this review, we overview the mechanisms by which DNA and RNA viruses manage p53 signaling in favor of their continued survival. Copyright © 2012 John Wiley & Sons, Ltd.

Journal

Reviews in Medical VirologyWiley

Published: Jul 1, 2013

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