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According to current textbooks, a well‐defined three‐dimensional structure is a prerequisite for the function of a protein. Is this correct?

According to current textbooks, a well‐defined three‐dimensional structure is a prerequisite for... According to current textbooks, a well-defined three-dimensional structure is a prerequisite for the function of a protein. Is this correct? H. Jane Dyson and Peter E. Wright The Scripps Research Institute, La Jolla, California, USA Is There an Answer? is intended to serve as a forum in which readers to IUBMB Life may pose questions of the type that intrigue biochemists but for which there may be no obvious answer or one may be available but not widely known or easily accessible. Readers are invited to e-mail [email protected] if they have questions to contribute or if they can provide answers to questions that are provided here from time to time. In the latter case, instructions will be sent to interested readers. Answers should be, whenever possible, evidencebased and provide relevant references. –Frank Vella We have been inundated with so many beautiful structures of macromolecules and complexes over the past few years that it is hard to visualize anything but a highly ordered and organized biological universe. However, nature is much cannier than that, and makes use of a spectrum of alternatively structured states to achieve biological goals. The existence of unstructured proteins in a functional context has been http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png IUBMB Life Wiley

According to current textbooks, a well‐defined three‐dimensional structure is a prerequisite for the function of a protein. Is this correct?

Dyson, H. Jane; Wright, Peter E.
IUBMB Life , Volume 58 (2) – Feb 1, 2006
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References (38)

Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2006 International Union of Biochemistry and Molecular Biology
ISSN
1521-6543
eISSN
1521-6551
DOI
10.1080/15216540500484376
pmid
16608823
Publisher site
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Abstract

According to current textbooks, a well-defined three-dimensional structure is a prerequisite for the function of a protein. Is this correct? H. Jane Dyson and Peter E. Wright The Scripps Research Institute, La Jolla, California, USA Is There an Answer? is intended to serve as a forum in which readers to IUBMB Life may pose questions of the type that intrigue biochemists but for which there may be no obvious answer or one may be available but not widely known or easily accessible. Readers are invited to e-mail [email protected] if they have questions to contribute or if they can provide answers to questions that are provided here from time to time. In the latter case, instructions will be sent to interested readers. Answers should be, whenever possible, evidencebased and provide relevant references. –Frank Vella We have been inundated with so many beautiful structures of macromolecules and complexes over the past few years that it is hard to visualize anything but a highly ordered and organized biological universe. However, nature is much cannier than that, and makes use of a spectrum of alternatively structured states to achieve biological goals. The existence of unstructured proteins in a functional context has been

Journal

IUBMB Life – Wiley

Published: Feb 1, 2006

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