Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

The IL23 axis plays a key role in the pathogenesis of IBD

The IL23 axis plays a key role in the pathogenesis of IBD Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Gut British Medical Journal

The IL23 axis plays a key role in the pathogenesis of IBD

Gut , Volume 56 (10) – Oct 13, 2007

The IL23 axis plays a key role in the pathogenesis of IBD

Gut , Volume 56 (10) – Oct 13, 2007

Abstract


Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD.

Loading next page...
 
/lp/british-medical-journal/the-il23-axis-plays-a-key-role-in-the-pathogenesis-of-ibd-jim2QHUpke

References (35)

Publisher
British Medical Journal
Copyright
Copyright 2007 by Gut
ISSN
0017-5749
eISSN
1468-3288
DOI
10.1136/gut.2006.115402
Publisher site
See Article on Publisher Site

Abstract

Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD.

Journal

GutBritish Medical Journal

Published: Oct 13, 2007

Keywords: DC, dendritic cell IBD, irritable bowel disease IFNγ, interferon γ IL, interleukin IL23R, interleukin 23 receptor SNP, single-nucleotide polymorphism TGFβ, transforming growth factor β Th, T helper TNFα, tumour necrosis factor α

There are no references for this article.