(2004)
J Urban Health
(2002)
Genome Res
(2002)
J. Immunol
Xiangping Zhang, Hai-jing Zhang, Yun Zhang, Ying-Jie Fu, Jie He, Li-ping Zhu, Shu-hui Wang, Li Liu (2005)
Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cellsImmunogenetics, 57
D. Yen, Jeanne Cheung, H. Scheerens, F. Poulet, T. Mcclanahan, Brent McKenzie, M. Kleinschek, A. Owyang, J. Mattson, W. Blumenschein, E. Murphy, M. Sathe, D. Cua, R. Kastelein, D. Rennick (2006)
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6.The Journal of clinical investigation, 116 5
P. Mannon, I. Fuss, L. Mayer, C. Elson, W. Sandborn, D. Present, B. Dolin, Nancy Goodman, C. Groden, R. Hornung, M. Quezado, Zhiqiong Yang, M. Neurath, J. Salfeld, G. Veldman, U. Schwertschlag, W. Strober (2004)
Anti-interleukin-12 antibody for active Crohn's disease.The New England journal of medicine, 351 20
Sanae Fujino, A. Andoh, S. Bamba, A. Ogaẃa, K. Hata, Y. Araki, T. Bamba, Y. Fujiyama (2003)
Increased expression of interleukin 17 in inflammatory bowel diseaseGut, 52
Y. Ogura, D. Bonen, N. Inohara, D. Nicolae, Felicia Chen, Richard Ramos, Heidi Britton, Thomas Moran, Reda Karaliuskas, R. Duerr, J. Achkar, S. Brant, T. Bayless, B. Kirschner, S. Hanauer, G. Núñez, Judy Cho (2001)
A frameshift mutation in NOD2 associated with susceptibility to Crohn's diseaseNature, 411
B. Oppmann, R. Lesley, B. Blom, J. Timans, Y. Xu, B. Hunte, F. Vega, N. Yu, J. Wang, K. Singh, F. Zonin, E. Vaisberg, T. Churakova, M. Liu, D. Gorman, J Wagner, S. Zurawski, Y. Liu, J. Abrams, K. Moore, D. Rennick, R. Waal‐Malefyt, C. Hannum, J. Bazan, R. Kastelein (2000)
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.Immunity, 13 5
F. Verreck, T. Boer, Dennis Langenberg, Marieke Hoeve, Matthijs Kramer, E. Vaisberg, R. Kastelein, A. Kolk, R. Waal‐Malefyt, T. Ottenhoff (2004)
Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria.Proceedings of the National Academy of Sciences of the United States of America, 101 13
Brent McKenzie, R. Kastelein, D. Cua (2006)
Understanding the IL-23-IL-17 immune pathway.Trends in immunology, 27 1
J. Rioux, M. Daly, M. Silverberg, K. Lindblad, H. Steinhart, Z. Cohen, T. Delmonte, Kerry Kocher, Katie Miller, Sheila Guschwan, E. Kulbokas, Sinead O'Leary, E. Winchester, K. Dewar, Todd Green, Valerie Stone, C. Chow, A. Cohen, Diane Langelier, Gilles Lapointe, D. Gaudet, J. Faith, Nancy Branco, S. Bull, R. McLeod, A. Griffiths, A. Bitton, G. Greenberg, E. Lander, K. Siminovitch, T. Hudson (2001)
Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn diseaseNature Genetics, 29
(2005)
The International HapMap Consortium
(2005)
Genes Immun
(2004)
N. Engl. J. Med
(2000)
Am J Hum Genet
M. Kendall (1937)
Statistical Methods for Research WorkersNature, 139
B. Kaufman, A. Rogers (1976)
Gastroenterology.Postgraduate medicine, 60 3
L. Wilkinson (1891)
ImmunityThe Indian Medical Gazette, 26
姚利晓, 蔡幼民, 林矫矫, 刘金明 (2005)
IL-13受体α2降低血吸虫病肉芽肿的炎症反应并延长宿主存活时间[英]/Mentink-Kane MM,Cheever AW，Thompson RW，et al//Proc Natl Acad Sci U S A, 32
J. Hugot, M. Chamaillard, H. Zouali, S. Lesage, J. Cézard, J. Belaiche, S. Almér, C. Tysk, C. O'Morain, M. Gassull, V. Binder, Y. Finkel, A. Cortot, R. Modigliani, P. Laurent-Puig, C. Gower-Rousseau, J. Macry, J. Colombel, M. Sahbatou, G. Thomas (2001)
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's diseaseNature, 411
(2006)
Nucleic Acids Res
E. Bettelli, Yijun Carrier, Wenda Gao, T. Korn, T. Strom, M. Oukka, H. Weiner, V. Kuchroo (2006)
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsNature, 441
(2006)
Inflamm Bowel Dis
(2006)
Transforming growth factor-b induces development of the TH 17 lineage Paul
NIDDK IBD Program Project Grant DK 46763
A. Cooper, A. Kipnis, J. Turner, J. Magram, J. Ferrante, I. Orme (2002)
Mice Lacking Bioactive IL-12 Can Generate Protective, Antigen-Specific Cellular Responses to Mycobacterial Infection Only if the IL-12 p40 Subunit Is Present1The Journal of Immunology, 168
(2005)
Bioinformatics
I. Fuss, C. Becker, Zhiqiong Yang, C. Groden, R. Hornung, F. Heller, M. Neurath, W. Strober, P. Mannon (2006)
Both IL‐12p70 and IL‐23 are synthesized during active Crohn's disease and are down‐regulated by treatment with anti‐IL‐12 p40 monoclonal antibodyInflammatory Bowel Diseases, 12
(2003)
Nature
S. Aggarwal, N. Ghilardi, M. Xie, F. Sauvage, A. Gurney (2003)
Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17*The Journal of Biological Chemistry, 278
K. Bender (2005)
ImmunogeneticsGenes and Immunity, 6
Materials and methods are available as supporting material on Science Online
(2001)
Nat. Genet
The National Institute of Diabetes and Digestive and Kidney Diseases IBD Genetics Consortium is funded by the following grants
(2003)
J. Clin. Invest
M. Veldhoen, R. Hocking, C. Atkins, R. Locksley, B. Stockinger (2006)
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.Immunity, 24 2
Jeremy Freese, Jason Beckfield (2003)
Categorical Data AnalysisTechnometrics, 45
C. Becker, Heike Dornhoff, C. Neufert, M. Fantini, S. Wirtz, S. Huebner, A. Nikolaev, H. Lehr, A. Murphy, D. Valenzuela, G. Yancopoulos, P. Galle, M. Karow, M. Neurath (2006)
Cutting Edge: IL-23 Cross-Regulates IL-12 Production in T Cell-Dependent Experimental Colitis1The Journal of Immunology, 177
C. Murphy, C. Langrish, Yi Chen, W. Blumenschein, T. Mcclanahan, R. Kastelein, J. Sedgwick, D. Cua (2003)
Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune InflammationThe Journal of Experimental Medicine, 198
J. Nadeau, E. Topol (2006)
The genetics of healthNature Genetics, 38
C. Parham, M. Chirica, J. Timans, E. Vaisberg, M. Travis, Jeanne Cheung, S. Pflanz, Rebecca Zhang, Komal Singh, F. Vega, W. To, J. Wagner, A. O'Farrell, T. Mcclanahan, S. Zurawski, C. Hannum, D. Gorman, D. Rennick, R. Kastelein, R. Malefyt, K. Moore (2002)
A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R1The Journal of Immunology, 168
C. Langrish, Yi Chen, W. Blumenschein, J. Mattson, B. Basham, J. Sedgwick, T. Mcclanahan, R. Kastelein, D. Cua (2005)
IL-23 drives a pathogenic T cell population that induces autoimmune inflammationThe Journal of Experimental Medicine, 201
M. Wiekowski, Michael Leach, Ellen Evans, L. Sullivan, Shu‐Cheng Chen, G. Vassileva, J. Bazan, Daniel Gorman, R. Kastelein, S. Narula, Sergio Lira (2001)
Ubiquitous Transgenic Expression of the IL-23 Subunit p19 Induces Multiorgan Inflammation, Runting, Infertility, and Premature DeathThe Journal of Immunology, 166
V. Peltekova, R. Wintle, L. Rubin, C. Amos, Qiqing Huang, X. Gu, B. Newman, M. Oene, D. Cescon, G. Greenberg, A. Griffiths, P. George-Hyslop, K. Siminovitch (2004)
Functional variants of OCTN cation transporter genes are associated with Crohn diseaseNature Genetics, 36
S9. The authors would like to acknowledge the important contributions of Gillian Bromfield
E. Loftus (2004)
Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences.Gastroenterology, 126 6
We acknowledge support from the Crohn's & Colitis Foundation of
(2003)
J. Biol. Chem
References and Notes S1
D. Cua, J. Sherlock, Yi Chen, C. Murphy, Barbara Joyce, B. Seymour, L. Lucian, W. To, Sylvia Kwan, T. Churakova, S. Zurawski, M. Wiekowski, S. Lira, D. Gorman, R. Kastelein, J. Sedgwick (2003)
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brainNature, 421
Science – Unpaywall
Published: Oct 27, 2006
Access the full text.
Sign up today, get DeepDyve free for 14 days.