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A systems biology viewpoint on autophagy in health and disease

A systems biology viewpoint on autophagy in health and disease a,b a a,b,c Alan Huett , Gautam Goel and Ramnik J. Xavier Center for Computational and Integrative Biology, Purpose of review Gastrointestinal Unit, Center for Inflammatory Bowel The field of autophagy is rapidly expanding to encompass many important areas of cell Disease, Massachusetts General Hospital, Harvard Medical School, Boston and The Broad Institute of biology, physiology and disease. Recent discoveries and tools allow the connection of MIT and Harvard, Cambridge, Massachusetts, USA the autophagy pathway to other cellular signals and processes, thus beginning a Correspondence to Ramnik J. Xavier, Center for systematic approach to elucidation of autophagy components, functions and Computational and Integrative Biology, Massachusetts connections. General Hospital, Richard B. Simches Research Center, 185 Cambridge Street, 7th Floor, Boston, MA Recent findings 02114, USA We outline recent discoveries illustrating the role of autophagy in Parkinson’s disease, Tel: +1 6176433331; fax: +1 617 643 3328; e-mail: [email protected], inflammatory bowel disease (IBD) and cancer. Recently important details of the [email protected], mechanisms by which autophagy operates in these contexts have been elucidated. We [email protected] illustrate how autophagy can be triggered by diverse stimuli and how cell fate is Current Opinion in Gastroenterology 2010, determined by the responses to many signals and stresses. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Gastroenterology Wolters Kluwer Health

A systems biology viewpoint on autophagy in health and disease

Xavier, Ramnik J
Current Opinion in Gastroenterology , Volume 26 (4) – Jul 1, 2010
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References (48)

ISSN
0267-1379
eISSN
1531-7056
DOI
10.1097/MOG.0b013e32833ae2ed
pmid
20571384
Publisher site
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Abstract

a,b a a,b,c Alan Huett , Gautam Goel and Ramnik J. Xavier Center for Computational and Integrative Biology, Purpose of review Gastrointestinal Unit, Center for Inflammatory Bowel The field of autophagy is rapidly expanding to encompass many important areas of cell Disease, Massachusetts General Hospital, Harvard Medical School, Boston and The Broad Institute of biology, physiology and disease. Recent discoveries and tools allow the connection of MIT and Harvard, Cambridge, Massachusetts, USA the autophagy pathway to other cellular signals and processes, thus beginning a Correspondence to Ramnik J. Xavier, Center for systematic approach to elucidation of autophagy components, functions and Computational and Integrative Biology, Massachusetts connections. General Hospital, Richard B. Simches Research Center, 185 Cambridge Street, 7th Floor, Boston, MA Recent findings 02114, USA We outline recent discoveries illustrating the role of autophagy in Parkinson’s disease, Tel: +1 6176433331; fax: +1 617 643 3328; e-mail: [email protected], inflammatory bowel disease (IBD) and cancer. Recently important details of the [email protected], mechanisms by which autophagy operates in these contexts have been elucidated. We [email protected] illustrate how autophagy can be triggered by diverse stimuli and how cell fate is Current Opinion in Gastroenterology 2010, determined by the responses to many signals and stresses.

Journal

Current Opinion in Gastroenterology – Wolters Kluwer Health

Published: Jul 1, 2010

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