Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Autophagy in Infection and ImmunityAn Overview of the Molecular Mechanism of Autophagy

Autophagy in Infection and Immunity: An Overview of the Molecular Mechanism of Autophagy [Autophagy is a highly conserved cellular degradation process in which portions of cytosol and organelles are sequestered into a double-membrane vesicle, an autophagosome, and delivered into a degradative organelle, the vacuole/lysosome, for breakdown and eventual recycling of the resulting macromolecules. This process relieves the cell from various stress conditions. Autophagy plays a critical role during cellular development and differentiation, functions in tumor suppression, and may be linked to life span extension. Autophagy also has diverse roles in innate and adaptive immunity, such as resistance to pathogen invasion. Substantial progress has been made in the identification of many autophagy-related (ATG) genes that are essential to drive this cellular process, including both selective and nonselective types of autophagy. Identification of the ATG genes in yeast, and the finding of orthologs in other organisms, reveals the conservation of the autophagic machinery in all eukaryotes. Here, we summarize our current knowledge about the machinery and molecular mechanism of autophagy.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Autophagy in Infection and ImmunityAn Overview of the Molecular Mechanism of Autophagy

Part of the Current Topics in Microbiology and Immunology Book Series (volume 335)
Editors: Levine, Beth; Yoshimori, Tamotsu; Deretic, Vojo
Yang, Zhifen; Klionsky, Daniel J.
Autophagy in Infection and Immunity — Aug 28, 2009
Download PDF
31 pages

Loading next page...
 
/lp/springer-journals/autophagy-in-infection-and-immunity-an-overview-of-the-molecular-yVTJTU504U

References (159)

Publisher
Springer Berlin Heidelberg
Copyright
© Springer-Verlag Berlin Heidelberg 2009
ISBN
978-3-642-00301-1
Pages
1–32
DOI
10.1007/978-3-642-00302-8_1
Publisher site
See Chapter on Publisher Site

Abstract

[Autophagy is a highly conserved cellular degradation process in which portions of cytosol and organelles are sequestered into a double-membrane vesicle, an autophagosome, and delivered into a degradative organelle, the vacuole/lysosome, for breakdown and eventual recycling of the resulting macromolecules. This process relieves the cell from various stress conditions. Autophagy plays a critical role during cellular development and differentiation, functions in tumor suppression, and may be linked to life span extension. Autophagy also has diverse roles in innate and adaptive immunity, such as resistance to pathogen invasion. Substantial progress has been made in the identification of many autophagy-related (ATG) genes that are essential to drive this cellular process, including both selective and nonselective types of autophagy. Identification of the ATG genes in yeast, and the finding of orthologs in other organisms, reveals the conservation of the autophagic machinery in all eukaryotes. Here, we summarize our current knowledge about the machinery and molecular mechanism of autophagy.]

Published: Aug 28, 2009

Keywords: Autophagosome Formation; Autophagic Activity; Selective Autophagy; Active Cysteine; Atg16 Complex

There are no references for this article.