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Vitamins E and C in the Prevention of Cardiovascular Disease in Men

Vitamins E and C in the Prevention of Cardiovascular Disease in Men ORIGINAL CONTRIBUTION JAMA-EXPRESS Vitamins E and C in the Prevention of Cardiovascular Disease in Men The Physicians’ Health Study II Randomized Controlled Trial Howard D. Sesso, ScD, MPH Context Basic research and observational studies suggest vitamin E or vitamin C may Julie E. Buring, ScD reduce the risk of cardiovascular disease. However, few long-term trials have evalu- ated men at initially low risk of cardiovascular disease, and no previous trial in men William G. Christen, ScD has examined vitamin C alone in the prevention of cardiovascular disease. Tobias Kurth, MD, ScD Objective To evaluate whether long-term vitamin E or vitamin C supplementation Charlene Belanger, MA decreases the risk of major cardiovascular events among men. Jean MacFadyen, BA Design, Setting, and Participants The Physicians’ Health Study II was a random- ized, double-blind, placebo-controlled factorial trial of vitamin E and vitamin C that Vadim Bubes, PhD began in 1997 and continued until its scheduled completion on August 31, 2007. There JoAnn E. Manson, MD, DrPH were 14 641 US male physicians enrolled, who were initially aged 50 years or older, Robert J. Glynn, ScD including 754 men (5.1%) with prevalent cardiovascular disease at randomization. Intervention Individual supplements of 400 IU of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Vitamins E and C in the Prevention of Cardiovascular Disease in Men

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References (73)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2008.600
pmid
18997197
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION JAMA-EXPRESS Vitamins E and C in the Prevention of Cardiovascular Disease in Men The Physicians’ Health Study II Randomized Controlled Trial Howard D. Sesso, ScD, MPH Context Basic research and observational studies suggest vitamin E or vitamin C may Julie E. Buring, ScD reduce the risk of cardiovascular disease. However, few long-term trials have evalu- ated men at initially low risk of cardiovascular disease, and no previous trial in men William G. Christen, ScD has examined vitamin C alone in the prevention of cardiovascular disease. Tobias Kurth, MD, ScD Objective To evaluate whether long-term vitamin E or vitamin C supplementation Charlene Belanger, MA decreases the risk of major cardiovascular events among men. Jean MacFadyen, BA Design, Setting, and Participants The Physicians’ Health Study II was a random- ized, double-blind, placebo-controlled factorial trial of vitamin E and vitamin C that Vadim Bubes, PhD began in 1997 and continued until its scheduled completion on August 31, 2007. There JoAnn E. Manson, MD, DrPH were 14 641 US male physicians enrolled, who were initially aged 50 years or older, Robert J. Glynn, ScD including 754 men (5.1%) with prevalent cardiovascular disease at randomization. Intervention Individual supplements of 400 IU of

Journal

JAMA – American Medical Association

Published: Nov 12, 2008

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