Key PointsQuestionDoes high-dose intravenous vitamin C reduce a composite of 28-day mortality and persistent organ dysfunction in patients with severe burn injury? FindingsIn this randomized clinical trial that included 238 patients with severe burns, the primary composite outcome of 28-day mortality and persistent organ dysfunction occurred in 40.8% of patients in the intravenous vitamin C group compared with 29.7% in the placebo group. At the first prespecified interim analysis, this result crossed the futility/harm threshold, prompting early termination of the trial. MeaningHigh-dose intravenous vitamin C did not reduce mortality and organ dysfunction and may be associated with harm in patients with severe burn injury.

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LitStream Collection

High-Dose Vitamin C in Burns

Greenhalgh, David G.

2026 JAMA

doi: 10.1001/jama.2026.10573pmid: N/A

journal article

LitStream Collection

Integrated Telehealth Rehabilitation and Quality of Life in Mechanically Ventilated Adults

Rosa, Regis Goulart; Moraes, Rafael Barberena; Trott, Geraldine; dos Santos, Maura Cristina; Miozzo, Aline Paula; Andrade, Alessandra; de Souza, Jennifer Menna Barreto; Wanderley, Juliana; Mocellin, Duane; de Almeida, Thais Martins; dos Santos, Rosa da Rosa Minho; De Matos, Luciana Diniz Nagem Janot; De Carli, Raíne Fogliati;

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New England Journal of Medicine BMC Medicine Medicine (United States)Clinical Science Medical Journal of Australia Sleep Medicine Nature Reviews Disease Primers BMJ Open British Medical Bulletin Annals of Medicine

Caserta, Raquel Afonso;

de Souza Roldão, Emelyn;

Ferreira, Milene Silva;

Farias, Sheila Esteves;

Asato, Mauro Shosuka;

João, Guilherme Augusto Pivoto;

De Almeida, Guacyra Margarita Batista;

De Oliveira, Claudio Dornas;

Júnior, Robson Oliveira Costa;

Silva, Marcia Dalvino De Alencar;

Furtado, Maria Janailda Araujo;

De Oliveira, Danielle Furtado;

Abreu, Márcia Maria De Lima;

Flores, Ladyanne Kessin;

Meira Teles, José Mário;

Falcão, Sandra Nívea Dos Reis Saraiva;

Fernandes, Tainara Fagundes;

Nobre, Vitor Camboim;

Crisostomo, Álex Mendes;

Rossato, Eduardo Vestena;

da Silva Macedo, Larissa Mendes;

Boaventura, Maurício Mascarenhas;

Alves Gonçalves, Francisco Pirauá;

Teixeira, Cassiano;

Rolim Ferraz, Leonardo Jose;

Cavaliere, Yasmin Ferreira;

Zampieri, Fernando G.;

Pereira, Adriano José

2026 JAMA

doi: 10.1001/jama.2026.10617pmid: N/A

Key PointsQuestionAmong adults with acute hypoxemic respiratory failure requiring invasive mechanical ventilation, does an integrated multicomponent telehealth-based rehabilitation intervention delivered across the intensive care unit, hospital ward, and postdischarge periods improve health-related quality of life at 90 days after hospital discharge compared with usual care? FindingsIn this stepped-wedge cluster randomized clinical trial including 1916 patients, mean quality of life utility scores at 90 days after hospital discharge were higher in the intervention group (0.16; SD, 0.31) than in the usual care group (0.12; SD, 0.28). This improvement appeared to be primarily associated with lower mortality rather than higher postdischarge quality-of-life scores among survivors. MeaningIn this study, among adults with acute hypoxemic respiratory failure requiring invasive mechanical ventilation, an integrated telehealth-based rehabilitation strategy spanning ICU, hospital ward, and postdischarge phases improved 90-day health-related quality of life.