Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/oxford-university-press/is-continuous-infusion-of-lactam-antibiotics-worthwhile-efficacy-and-e7zIHO0McA
References (38)
-
D. Merrikin, J. Briant, G. Rolinson (1983)
Effect of protein binding on antibiotic activity in vivo.The Journal of antimicrobial chemotherapy, 11 3
-
J. Knudsen, Niels Frimodt-Møller, F. Espersen (1995)
Experimental Streptococcus pneumoniae infection in mice for studying correlation of in vitro and in vivo activities of penicillin against pneumococci with various susceptibilities to penicillinAntimicrobial Agents and Chemotherapy, 39
-
W. Craig, S. Ebert (1992)
Continuous infusion of beta-lactam antibioticsAntimicrobial Agents and Chemotherapy, 36
-
T. David, J. Devlin (1989)
CONTINUOUS INFUSION OF CEFTAZIDIME IN CYSTIC FIBROSISThe Lancet, 333
-
S. Daenen, H. Vries-Hospers (1988)
CURE OF PSEUDOMONAS AERUGINOSA INFECTION IN NEUTROPENIC PATIENTS BY CONTINUOUS INFUSION OF CEFTAZIDIMEThe Lancet, 331
-
L. Visser, P. Arnouts, R. Furth, H. Mattie, P. Broek (1993)
Clinical pharmacokinetics of continuous intravenous administration of penicillins.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 17 3
-
(1986)
Methods for evaluating the penetration of beta-lactams into tissues -
(1994)
Determination of the in vivo efficaceous serum concentrations of ceftazidime administered as continuous infusion on an experimental model of Pseudomonas aeruginosa rabbit endocarditis model -
(1987)
The relation between plasma and tissue concentrations of antibiotics -
J. Mouton, J. Anker (1995)
Meropenem Clinical PharmacokineticsClinical Pharmacokinetics, 28
-
R. Wise (1983)
Protein binding of beta-lactams: the effects on activity and pharmacology particularly tissue penetration. I.The Journal of antimicrobial chemotherapy, 12 1
-
R. Roosendaal, I. Bakker-Woudenberg, J. Berg, M. Michel (1985)
Therapeutic efficacy of continuous versus intermittent administration of ceftazidime in an experimental Klebsiella pneumoniae pneumonia in rats.The Journal of infectious diseases, 152 2
-
W. Johan, Mouton, A. Horrevorts, Paul Mulder, Eroll Prens, Marc Michel (1990)
Pharmacokinetics of ceftazidime in serum and suction blister fluid during continuous and intermittent infusions in healthy volunteersAntimicrobial Agents and Chemotherapy, 34
-
D. Cappelletty, S. Kang, S. Palmer, M. Rybak (1995)
Pharmacodynamics of ceftazidime administered as continuous infusion or intermittent bolus alone and in combination with single daily-dose amikacin against Pseudomonas aeruginosa in an in vitro infection modelAntimicrobial Agents and Chemotherapy, 39
-
(1994)
Comparative ceftazidime serum concentrations during continuous infusion in healthy subjects and severe burn patients -
(1993)
Ceftazidime and vancomycin constant-rate infusion in neutropenic children: pharmacokinetic parameters and clinical implications -
Johan Mouton, Marc Michel (1991)
Pharmacokinetics of meropenem in serum and suction blister fluid during continuous and intermittent infusion.The Journal of antimicrobial chemotherapy, 28 6
-
M. Klepser, M. Marangos, K. Patel, D. Nicolau, R. Quintiliani, C. Nightingale (1995)
Clinical Pharmacokinetics of Newer CephalosporinsClinical Pharmacokinetics, 28
-
(1995)
Aztreonam pharmacokinetics after single dose and during home -
A. Vinks, D. Touw, H. Heijerman, M. Danhof, Gerard Leede, W. Bakker (1994)
Pharmacokinetics of Ceftazidime in Adult Cystic Fibrosis Patients During Continuous Infusion and Ambulatory Treatment at HomeTherapeutic Drug Monitoring, 16
-
Jerome Schentag, I. Smith, D. Swanson, C. DeAngelis, J. Fracasso, A. Vari, J. Vance (1984)
Role for dual individualization with cefmenoxime.The American journal of medicine, 77 6A
-
H. Smith, J. Dewdney, A. Wheeler (1971)
A comparison of the amounts and the antigenicity of polymeric materials formed in aqueous solution by some beta-lactam antibiotics.Immunology, 21 3
-
A. Vinks, J. Mouton, D. Touw, H. Heijerman, M. Danhof, W. Bakker (1996)
Population pharmacokinetics of ceftazidime in cystic fibrosis patients analyzed by using a nonparametric algorithm and optimal sampling strategyAntimicrobial Agents and Chemotherapy, 40
-
G. Drusano (1990)
Human pharmacodynamics of beta-lactams, aminoglycosides and their combination.Scandinavian journal of infectious diseases. Supplementum, 74
-
K. Giacomini, S. Roberts, G. Levy (1981)
Evaluation of methods for producing renal dysfunction in rats.Journal of pharmaceutical sciences, 70 2
-
G. Bodey, S. Ketchel, V. Rodriguez (1979)
A randomized study of carbenicillin plus cefamandole or tobramycin in the treatment of febrile episodes in cancer patients.The American journal of medicine, 67 4
-
B. Vogelman, W. Craig (1986)
Kinetics of antimicrobial activity.The Journal of pediatrics, 108 5 Pt 2
-
R. Wise (1983)
Protein binding of beta-lactams: the effects on activity and pharmacology particularly tissue penetration. II. Studies in man.The Journal of antimicrobial chemotherapy, 12 2
-
(1994)
Ceftazidime serum bactericidal activity continuous infusion versus intermittent injections In Program and Abstracts of the Thirty-Fourth -
(1990)
Drug Data Handbook -
W. Craig (1993)
Qualitative susceptibility tests versus quantitative MIC tests.Diagnostic microbiology and infectious disease, 16 3
-
C. Onyeji, D. Nicolau, C. Nightingale, R. Quintiliani (1994)
Optimal times above MICs of ceftibuten and cefaclor in experimental intra-abdominal infectionsAntimicrobial Agents and Chemotherapy, 38
-
A. Hedman, Y. Adan-Abdi, G. Alvan, B. Strandvik, A. Arvidsson (1988)
Influence of the Glomerular Filtration Rate on Renal Clearance of Ceftazidime in Cystic FibrosisClinical Pharmacokinetics, 15
-
M. Barza, G. Cuchural (1985)
General principles of antibiotic tissue penetration.The Journal of antimicrobial chemotherapy, 15 Suppl A
-
Johan Mouton, G. Jan, Den, Hollander (1994)
Killing of Pseudomonas aeruginosa during continuous and intermittent infusion of ceftazidime in an in vitro pharmacokinetic modelAntimicrobial Agents and Chemotherapy, 38
-
Ursula Fluckiger, C. Segessenmann, Andreas Gerber, Regionalspital Burgdorf (1991)
Integration of pharmacokinetics and pharmacodynamics of imipenem in a human-adapted mouse modelAntimicrobial Agents and Chemotherapy, 35
-
M. Spino (1991)
Pharmacokinetics of drugs in cystic fibrosisClinical Reviews in Allergy, 9
-
R. Roosendaal, I. Bakker-Woudenberg, M. Raffe, M. Michel (1986)
Continuous versus intermittent administration of ceftazidime in experimental Klebsiella pneumoniae pneumonia in normal and leukopenic ratsAntimicrobial Agents and Chemotherapy, 30
- Publisher
- Oxford University Press
- Copyright
- Copyright © 2015 British Society for Antimicrobial Chemotherapy
- ISSN
- 0305-7453
- eISSN
- 1460-2091
- DOI
- 10.1093/jac/38.1.5
- Publisher site
- See Article on Publisher Site
Abstract
The most important pharmacodynamic parameter for β-lactam antibiotics has been shown to be the time above the MIC, which is used as an argument to administer β-lactam antibiotics by continuous infusion. Studies in vitro and in laboratory animals comparing efficacy of continuous and intermittent infusion of β-lactam antibiotics generally show continuous infusion to be more efficacious. While comparative trials in humans are scarce and a significant difference was only found in subgroup analysis in one study, several case-reports support the use of continuous infusion. Arguments in favour and against continuous infusion are discussed. Although dose-ranging studies have not yet been performed in humans, the results from in-vitro and in-vivo experiments indicate that 4 × MIC for the infecting bacterium would be the target concentration. Pharmacokinetic studies which have been performed in humans during continuous infusion show that serum concentrations can be predicted from total clearance or, using population pharmacokinetic modelling, the elimination rate constant as obtained during intermittent infusion. A nomogram is presented which allows calculation of the daily dose to obtain the target steady state blood concentrations suggested by the susceptibility of the infecting bacterium, usually 4 × MIC. For bacteria with a low MIC, the daily dose may be substantially lower than that used in conventional dosing regimens, while in infections which are difficult to treat as a result of more resistant bacteria, continuous infusion may be more effective than an equivalent bolus dose. © 1996 by the British Society for Antimicrobial Chemotherapy « Previous | Next Article » Table of Contents This Article J. Antimicrob. Chemother. (1996) 38 (1): 5-15. doi: 10.1093/jac/38.1.5 » Abstract Free Full Text (PDF) Free Classifications Review Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Similar articles in PubMed Add to my archive Download citation Request Permissions Disclaimer Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Mounton, J. W. Articles by Vinks, A. A. T. M. M. Search for related content PubMed PubMed citation Articles by Mounton, J. W. Articles by Vinks, A. A. T. M. M. Related Content Load related web page information Share Email this article CiteULike Delicious Facebook Google+ Mendeley Twitter What's this? Search this journal: Advanced » Current Issue November 2015 70 (11) Alert me to new issues The Journal About this journal Free leading articles Editor’s Choice Free Editorials JAC Supplements Rights & Permissions This journal is a member of the Committee on Publication Ethics We are mobile – find out more Journals Career Network Published on behalf of The British Society for Antimicrobial Chemotherapy Impact factor: 5.313 5-Yr impact factor: 4.984 Editor-in-Chief Dr Peter Donnelly View full editorial board For Authors Instructions to authors Online submission instructions Submit Now! Self-archiving policy Open access options for authors - visit Oxford Open This journal enables compliance with the NIH Public Access Policy WhsSvhnOkaAwYG81FJCYgwG7z1LnIP2F true Looking for your next opportunity? Looking for jobs... jQuery_1_11 = jQuery.noConflict(true); Alerting Services Email table of contents Email Advance Access CiteTrack XML RSS feed Corporate Services Advertising sales Reprints Supplements var taxonomies = ("MED00300", "MED00460"); Most Most Read Complicated urinary tract infections: practical solutions for the treatment of multiresistant Gram-negative bacteria The use of fluconazole and itraconazole in the treatment of Candida albicans infections: a review Antibacterial activity of essential oils and their major constituents against respiratory tract pathogens by gaseous contact Determination of minimum inhibitory concentrations Factors impacting on the problem of antibiotic resistance » View all Most Read articles Most Cited Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility Determination of minimum inhibitory concentrations Synergy, antagonism, and what the chequerboard puts between them Intercontinental emergence of Escherichia coli clone O25:H4-ST131 producing CTX-M-15 CTX-M: changing the face of ESBLs in Europe » View all Most Cited articles Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department. Online ISSN 1460-2091 - Print ISSN 0305-7453 Copyright © 2015 British Society for Antimicrobial Chemotherapy Oxford Journals Oxford University Press Site Map Privacy Policy Cookie Policy Legal Notices Frequently Asked Questions Other Oxford University Press sites: Oxford University Press Oxford Journals China Oxford Journals Japan Academic & Professional books Children's & Schools Books Dictionaries & Reference Dictionary of National Biography Digital Reference English Language Teaching Higher Education Textbooks International Education Unit Law Medicine Music Online Products & Publishing Oxford Bibliographies Online Oxford Dictionaries Online Oxford English Dictionary Oxford Language Dictionaries Online Oxford Scholarship Online Reference Rights and Permissions Resources for Retailers & Wholesalers Resources for the Healthcare Industry Very Short Introductions World's Classics function fnc_onDomLoaded() { var query_context = getQueryContext(); PF_initOIUnderbar(query_context,":QS:default","","JRN"); PF_insertOIUnderbar(0); }; if (window.addEventListener) { window.addEventListener('load', fnc_onDomLoaded, false); } else if (window.attachEvent) { window.attachEvent('onload', fnc_onDomLoaded); } var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); try { var pageTracker = _gat._getTracker("UA-189672-16"); pageTracker._setDomainName(".oxfordjournals.org"); pageTracker._trackPageview(); } catch(err) {}
Journal
Journal of Antimicrobial Chemotherapy – Oxford University Press
Published: Jul 1, 1996