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Journal of Antimicrobial Chemotherapy

Subject Areas: Infectious Diseases
Publisher: Oxford University Press - Oxford University Press
ISSN: 0305-7453
SJR: 194

Available

Journal Article

Impact of tenofovir on SARS-CoV-2 infection and severe outcomes among people living with HIV: a propensity score-matched study

Nomah, Daniel K.; Reyes-Urueña, Juliana; Díaz, Yesika; Moreno, Sergio; Aceiton, Jordi; Bruguera, Andreu; Vivanco-Hidalgo, Rosa M.; Casabona, Jordi; Domingo, Pere; Navarro, Jordi; Imaz, Arkaitz; Deig, Elisabet; Navarro, Gemma; Llibre, Josep M.; Miro, Jose M.; PISCIS study group; Muntada, Esteve; Esteve, Anna; Fanjul, Francisco; Falcó, Vicenç; Knobel, Hernando; Mallolas, Josep; Tiraboschi, Juan; Curran, Adrià; Burgos, Joaquín; Revollo, Boris; Gracia, Maria; Gutierrez, Maria del Mar; Murillas, Javier; Homar, Francisco; Fernández-Montero, Jose V.; González, Eva; Peraire, Joaquim; Force, Lluís; Leon, Elena; Hortos, Miquel; Vilaró, Ingrid; Orti, Amat; Dalmau, David; Jaen, Àngels; Lazzari, Elisa De; Berrocal, Leire; Rodríguez, Lucía; Gargoulas, Freya; Vanrell, Toni; Carlos, Jose; Vilà, Josep; Martínez, Marina; Morell, Bibiana; Tamayo, Maribel; Palacio, Jorge; Ambrosioni, Juan; Laguno, Montse; Martínez-Rebollar, María; Blanco, José L.; Garcia, Felipe; Torres, Berta; Mora, Lorena de la; Inciarte, Alexy; Ugarte, Ainoa; Chivite, Iván; González-Cordon, Ana; Leal, Lorna; Jou, Antoni; Negredo, Eugènia; Saumoy, Maria; Silva, Ana; Scévola, Sofia; Suanzes, Paula; Alvarez, Patricia; Mur, Isabel; Jaume, Melchor Riera; García-Gasalla, Mercedes; Ribas, Maria À.; Campins, Antoni A.; Peñaranda, María; Martin, María L.; Haydee, Helem; Calzado, Sònia; Cervantes, Manel; Navarro, Marta; Payeras, Antoni; Cifuentes, Carmen; Villoslada, Aroa; Sorní, Patrícia; Molero, Marta; Abdulghani, Nadia; Comella, Thaïs; Sola, Rocio; Vargas, Montserrat; Viladés, Consuleo; Martí, Anna; Yeregui, Elena; Rull, Anna; Barrufet, Pilar; Arbones, Laia; Chamarro, Elena; Escrig, Cristina; Cairó, Mireia; Martinez-Lacasa, Xavier; Font, Roser; Macorigh, Lizza; Hernández, Juanse

2022 Journal of Antimicrobial Chemotherapy

doi:10.1093/jac/dkac177 pmid:35678461

Abstract Background Reports on the impact of some antiretrovirals against SARS-CoV-2 infection and disease severity are conflicting. Objectives We evaluated the effect of tenofovir as either tenofovir alafenamide/emtricitabine (TAF/FTC) or tenofovir disoproxil fumarate/emtricitabine (TDF/FTC)...
Available

Journal Article

Global prevalence of resistance to macrolides in Mycoplasma pneumoniae: a systematic review and meta-analysis

Wang, Guotuan; Wu, Peng; Tang, Rui; Zhang, Weidong

2022 Journal of Antimicrobial Chemotherapy

doi:10.1093/jac/dkac170 pmid:35678262

Abstract Objectives To determine the prevalence of resistance to macrolides in Mycoplasma pneumoniae worldwide. Methods Prior to 12 December 2020, PubMed, Web of Science, Scopus and Embase databases were searched for epidemiological studies of M. pneumoniae resistance. Two reviewers independently...
Available

Journal Article

Detection of highly macrolide-resistant Legionella pneumophila strains from a hotel water network using systematic whole-genome sequencing

Ginevra, Christophe; Beraud, Laetitia; Pionnier, Isabelle; Sallabery, Kassandra; Bentayeb, Houcine; Simon, Bruno; Allam, Camille; Chastang, Joelle; Ibranosyan, Marine; Decroix, Véronique; Campese, Christine; Jarraud, Sophie; Descours, Ghislaine

2022 Journal of Antimicrobial Chemotherapy

doi:10.1093/jac/dkac173 pmid:35678276

Abstract Objectives Implementation of an antibiotic resistance detection tool in Legionella daily surveillance at the French National Reference Centre for Legionella. Methods Systematic WGS of Legionella pneumophila isolates and bioinformatics detection of specific mutations linked to antibiotic...
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Journal Article

Clonal relationship of tet(X4)-positive Escherichia coli ST761 isolates between animals and humans

Zhai, Weishuai; Wang, Tao; Yang, Dawei; Zhang, Qidi; Liang, Xiao; Liu, Zhihai; Sun, Chengtao; Wu, Congming; Liu, Dejun; Wang, Yang

2022 Journal of Antimicrobial Chemotherapy

doi:10.1093/jac/dkac175 pmid:35678277

Abstract Objectives To characterize the relationship of tet(X4)-positive isolates from different hosts and environments. Methods PCR and MALDI-TOF MS were used to identify the tet(X4)-positive isolates. The MICs of 13 antimicrobial agents were determined by broth microdilution. Illumina...
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Journal Article

Pharmacokinetics of standard versus high-dose isoniazid for treatment of multidrug-resistant tuberculosis

Gausi, Kamunkhwala; Chirehwa, Maxwell; Ignatius, Elisa H.; Court, Richard; Sun, Xin; Moran, Laura; Hafner, Richard; Wiesner, Lubbe; Rosenkranz, Susan L.; de Jager, Veronique; de Vries, Nihal; Harding, Joseph; Gumbo, Tawanda; Swindells, Susan; Diacon, Andreas; Dooley, Kelly E.; McIlleron, Helen; Denti, Paolo

2022 Journal of Antimicrobial Chemotherapy

doi:10.1093/jac/dkac188 pmid:35678468

Abstract Background The WHO-endorsed shorter-course regimen for MDR-TB includes high-dose isoniazid. The pharmacokinetics of high-dose isoniazid within MDR-TB regimens has not been well described. Objectives To characterize isoniazid pharmacokinetics at 5–15 mg/kg as monotherapy or as part of the...
Available

Journal Article

Comment on: Treatment efficacy for rectal Neisseria gonorrhoeae: a systematic review and meta-analysis of randomized controlled trials

Hsu, Yuan Pin; Chen, Liang Fu; Chen, Fu Lun; Liu, Ying Kuo

2022 Journal of Antimicrobial Chemotherapy

doi:10.1093/jac/dkac194 pmid:35733335

We recently read with great interest the article titled ‘Treatment efficacy for rectal Neisseria gonorrhoeae: a systematic review and meta-analysis of randomized controlled trials’.1 After reading this article, we would like to address a few points. Antimicrobial resistance of N. gonorrhoeae...
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Journal Article

Pharmacokinetic modelling of caspofungin to develop an extended dosing regimen in paediatric patients

Gastine, Silke; Hempel, Georg; Neely, Michael N.; Walsh, Thomas J.; Groll, Andreas H.

2022 Journal of Antimicrobial Chemotherapy

doi:10.1093/jac/dkac182

Abstract Background Echinocandins are commonly used in treatment and prophylaxis of invasive fungal diseases. Intravenous daily dosing for prophylaxis in the outpatient setting can however become a hurdle for adequate compliance in the paediatric population. Objectives Simulations were performed...
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Journal Article

The primary pharmacology of ceftazidime/avibactam: in vivo translational biology and pharmacokinetics/pharmacodynamics (PK/PD)

Nichols, Wright W.; Bradford, Patricia A.; Stone, Gregory G.

2022 Journal of Antimicrobial Chemotherapy

doi:10.1093/jac/dkac172 pmid:35660869

Abstract This review describes the translational in vivo and non-clinical pharmacokinetics/pharmacodynamics (PK/PD) research that supported clinical trialling and subsequently licensing approval of ceftazidime/avibactam, a new β-lactam/β-lactamase inhibitor combination aimed at the treatment of...
Available

Journal Article

Comment on: Impact of introducing procalcitonin testing on antibiotic usage in acute NHS hospitals during the first wave of COVID-19 in the UK: a controlled interrupted time series analysis of organization-level data

Su, Mei-Chin; Park, James Yeongjun; Hsu, Wan-Ting; Huang, Chung-Yen; Hsu, Chia-Chun; Yo, Chia-Hung; Lee, Chien-Chang

2022 Journal of Antimicrobial Chemotherapy

doi:10.1093/jac/dkac179

We read with great interest the article published recently in this Journal by Llewelyn et al.1 which provides an additional piece of evidence that procalcitonin (PCT) plays an important role in antimicrobial stewardship of COVID-19 patients. Besides the interrupted time series analysis, both the...
Available

Journal Article

Engineering a CRISPR interference system targeting AcrAB-TolC efflux pump to prevent multidrug resistance development in Escherichia coli

Wan, Xiulin; Li, Qingyang; Olsen, Rikke Heidemann; Meng, Hecheng; Zhang, Zhigang; Wang, Junlin; Zheng, Hanyu; Li, Lili; Shi, Lei

2022 Journal of Antimicrobial Chemotherapy

doi:10.1093/jac/dkac166 pmid:35642356

Abstract Objectives We engineered a CRISPR interference (CRISPRi) system targeting the AcrAB-TolC efflux pump to prevent MDR development in Escherichia coli. Methods Nine specific single-guide RNAs (sgRNAs) were designed to target the components of the AcrAB-TolC efflux pump, namely AcrA, AcrB...

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