Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/genetics-squared-combining-host-and-pathogen-genetics-in-the-analysis-cpJnkNLhVL
References (149)
-
A. Fortier, C. Chastellier, Stéphanie Balor, P. Gros (2007)
Birc1e/Naip5 rapidly antagonizes modulation of phagosome maturation by Legionella pneumophilaCellular Microbiology, 9
-
Javier Carrero, B. Calderon, E. Unanue (2004)
Type I Interferon Sensitizes Lymphocytes to Apoptosis and Reduces Resistance to Listeria InfectionThe Journal of Experimental Medicine, 200
-
A. Amer, L. Franchi, T. Kanneganti, M. Body-Malapel, Nesrin Özören, Graham Brady, Sasha Meshinchi, R. Jagirdar, A. Gewirtz, S. Akira, G. Núñez (2006)
Regulation of Legionella Phagosome Maturation and Infection through Flagellin and Host Ipaf*Journal of Biological Chemistry, 281
-
T. Lang, É. Prina, D. Sibthorpe, J. Blackwell (1997)
Nramp1 transfection transfers Ity/Lsh/Bcg-related pleiotropic effects on macrophage activation: influence on antigen processing and presentationInfection and Immunity, 65
-
Vasudeo Badarinarayana, Preston Estep, J. Shendure, J. Edwards, Saeed Tavazoie, Felix Lam, G. Church (2001)
Selection analyses of insertional mutants using subgenic-resolution arraysNature Biotechnology, 19
-
F. Martinon, K. Burns, J. Tschopp (2002)
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.Molecular cell, 10 2
-
K. Hisert, M. MacCoss, M. Shiloh, K. Darwin, Shaneen Singh, Roger Jones, S. Ehrt, Zhaoying Zhang, B. Gaffney, S. Gandotra, D. Holden, D. Murray, C. Nathan (2005)
A glutamate‐alanine‐leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMPMolecular Microbiology, 56
-
N Jabado, A Jankowski, S Dougaparsad, V Picard, S Grinstein, P Gros (2000)
Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membraneJ Exp Med, 192
-
R. Valdivia, S. Falkow (1997)
Fluorescence-based isolation of bacterial genes expressed within host cells.Science, 277 5334
-
C. Lynch, Cynthia Pierce-Chase, R. Dubos (1965)
A GENETIC STUDY OF SUSCEPTIBILITY TO EXPERIMENTAL TUBERCULOSIS IN MICE INFECTED WITH MAMMALIAN TUBERCLE BACILLIThe Journal of Experimental Medicine, 121
-
J. Watson, R. Riblet, B. Taylor (1977)
The response of recombinant inbred strains of mice to bacterial lipopolysaccharides.Journal of immunology, 118 6
-
Paul Kaye, J. Blackwell (1989)
Lsh, antigen presentation and the development of CMI.Research in immunology, 140 8
-
Ari Molofsky, B. Byrne, Natalie Whitfield, Cressida Madigan, E. Fuse, K. Tateda, M. Swanson (2006)
Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infectionThe Journal of Experimental Medicine, 203
-
D. Malo, K. Vogan, S. Vidal, J. Hu, M. Cellier, E. Schurr, A. Fuks, N. Bumstead, K. Morgan, P. Gros (1994)
Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites.Genomics, 23 1
-
N. Shimono, L. Morici, N. Casali, Sally Cantrell, B. Sidders, S. Ehrt, L. Riley (2003)
Hypervirulent mutant of Mycobacterium tuberculosis resulting from disruption of the mce1 operonProceedings of the National Academy of Sciences of the United States of America, 100
-
R. North, Ronald LaCourse, Lynn Ryan, P. Gros (1999)
Consequence of Nramp1 Deletion toMycobacterium tuberculosis Infection in MiceInfection and Immunity, 67
-
B. Beutler, Zhengfan Jiang, P. Georgel, K. Crozat, B. Croker, S. Rutschmann, Xin Du, K. Hoebe (2006)
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large.Annual review of immunology, 24
-
A. Diepen, T. Straaten, S. Holland, R. Janssen, J. Dissel (2002)
A Superoxide-Hypersusceptible Salmonella enterica Serovar Typhimurium Mutant Is Attenuated but Regains Virulence in p47phox−/− MiceInfection and Immunity, 70
-
D. Bradley (1974)
Genetic control of natural resistance to Leishmania donovaniNature, 250
-
J. Watters, K. Dewar, J. Lehoczky, V. Boyartchuk, W. Dietrich (2001)
Kif1C, a kinesin-like motor protein, mediates mouse macrophage resistance to anthrax lethal factorCurrent Biology, 11
-
O. Garifulin, Z. Qi, Hai-hong Shen, Sujatha Patnala, Michael Green, V. Boyartchuk (2007)
Irf3 Polymorphism Alters Induction of Interferon Beta in Response to Listeria monocytogenes InfectionPLoS Genetics, 3
-
M. Beckers, S. Yoshida, K. Morgan, E. Skamene, P. Gros (1995)
Natural resistance to infection with Legionella pneumophila: chromosomal localization of the Lgn1 susceptibility geneMammalian Genome, 6
-
E. Lander, D. Botstein (1989)
Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.Genetics, 121 1
-
Lauren Logsdon, J. Mecsas (2006)
The Proinflammatory Response Induced by Wild-Type Yersinia pseudotuberculosis Infection Inhibits Survival of yop Mutants in the Gastrointestinal Tract and Peyer's PatchesInfection and Immunity, 74
-
C. Sassetti, D. Boyd, E. Rubin (2001)
Comprehensive identification of conditionally essential genes in mycobacteriaProceedings of the National Academy of Sciences of the United States of America, 98
-
S. Yoshida, Y. Goto, Y. Mizuguchi, K. Nomoto, E. Skamene (1991)
Genetic control of natural resistance in mouse macrophages regulating intracellular Legionella pneumophila multiplication in vitroInfection and Immunity, 59
-
D. Merrell, D. Hava, A. Camilli (2002)
Identification of novel factors involved in colonization and acid tolerance of Vibrio choleraeMolecular Microbiology, 43
-
Andrés Vazquez-Terres, J. Jones-Carson, A. Bäumler, S. Falkow, Raphael Valdivia, Raphael Valdivia, William Brown, Mysan Lo, Ruth Berggren, Ruth Berggren, W. Parks, F. Fang (1999)
Extraintestinal dissemination of Salmonella by CD18-expressing phagocytesNature, 401
-
K. Hoshino, O. Takeuchi, T. Kawai, H. Sanjo, T. Ogawa, Y. Takeda, K. Takeda, S. Akira (1999)
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product.Journal of immunology, 162 7
-
M. Watarai, Isabelle Derré, J. Kirby, J. Growney, W. Dietrich, R. Isberg (2001)
Legionella pneumophila Is Internalized by a Macropinocytotic Uptake Pathway Controlled by the Dot/Icm System and the Mouse Lgn1 Locus✪The Journal of Experimental Medicine, 194
-
C. Janeway (1989)
Approaching the asymptote? Evolution and revolution in immunology.Cold Spring Harbor symposia on quantitative biology, 54 Pt 1
-
C. Stober, Sven Brode, Jacqueline White, Jean-François Popoff, J. Blackwell (2007)
Slc11a1, Formerly Nramp1, Is Expressed in Dendritic Cells and Influences Major Histocompatibility Complex Class II Expression and Antigen-Presenting Cell FunctionInfection and Immunity, 75
-
C. Sassetti, E. Rubin (2003)
Genetic requirements for mycobacterial survival during infectionProceedings of the National Academy of Sciences of the United States of America, 100
-
A. Talaat, R. Lyons, S. Howard, S. Johnston (2004)
The temporal expression profile of Mycobacterium tuberculosis infection in mice.Proceedings of the National Academy of Sciences of the United States of America, 101 13
-
A. Fortier, G. Min-oo, J. Forbes, Steven Lam-Yuk-Tseung, P. Gros (2005)
Single gene effects in mouse models of host: pathogen interactionsJournal of Leukocyte Biology, 77
-
Carlos Osorio, J. Crawford, Jane Michalski, Hector Martinez-Wilson, J. Kaper, Andrew Camilli (2005)
Second-Generation Recombination-Based In Vivo Expression Technology for Large-Scale Screening for Vibrio cholerae Genes Induced during Infection of the Mouse Small IntestineInfection and Immunity, 73
-
Ying Chang, B. Segal, S. Holland, G. Miller, K. Kwon-Chung (1998)
Virulence of catalase-deficient aspergillus nidulans in p47(phox)-/- mice. Implications for fungal pathogenicity and host defense in chronic granulomatous disease.The Journal of clinical investigation, 101 9
-
Melanie Brinkmann, E. Spooner, K. Hoebe, B. Beutler, H. Ploegh, You-Me Kim (2007)
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signalingThe Journal of Cell Biology, 177
-
K. Hisert, M. Kirksey, James Gomez, A. Sousa, J. Cox, W. Jacobs, C. Nathan, J. Mckinney (2004)
Identification of Mycobacterium tuberculosis Counterimmune (cim) Mutants in Immunodeficient Mice by Differential ScreeningInfection and Immunity, 72
-
M. Lamkanfi, A. Amer, T. Kanneganti, Raúl Muñoz-Planillo, Grace Chen, P. Vandenabeele, A. Fortier, P. Gros, G. Núñez (2007)
The Nod-Like Receptor Family Member Naip5/Birc1e Restricts Legionella pneumophila Growth Independently of Caspase-1 Activation1The Journal of Immunology, 178
-
L. Franchi, A. Amer, M. Body-Malapel, T. Kanneganti, Nesrin Özören, R. Jagirdar, N. Inohara, P. Vandenabeele, J. Bertin, A. Coyle, E. Grant, G. Núñez (2006)
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophagesNature Immunology, 7
-
Sara Montminy, N. Khan, S. McGrath, M. Walkowicz, Fiona Sharp, J. Conlon, K. Fukase, S. Kusumoto, C. Sweet, K. Miyake, S. Akira, R. Cotter, J. Goguen, E. Lien (2006)
Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide responseNature Immunology, 7
-
T. Caspary, Kathryn Anderson (2006)
Uncovering the uncharacterized and unexpected: Unbiased phenotype‐driven screens in the mouseDevelopmental Dynamics, 235
-
MJ Mahan, JM Slauch, JJ Mekalanos (1993)
Selection of bacterial virulence genes that are specifically induced in host tissuesScience, 259
-
M. Fleming, C. Trenor, M. Su, D. Foernzler, D. Beier, W. Dietrich, N. Andrews (1997)
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter geneNature Genetics, 16
-
Laura Burrack, D. Higgins (2007)
Genomic approaches to understanding bacterial virulence.Current opinion in microbiology, 10 1
-
C. Wade, M. Daly (2005)
Genetic variation in laboratory miceNature Genetics, 37
-
Andrew Revel, A. Talaat, M. Norgard (2002)
DNA microarray analysis of differential gene expression in Borrelia burgdorferi, the Lyme disease spirocheteProceedings of the National Academy of Sciences of the United States of America, 99
-
Ansel Hsiao, Zhi Liu, Adam Joelsson, Jun Zhu (2006)
Vibrio cholerae virulence regulator-coordinated evasion of host immunityProceedings of the National Academy of Sciences, 103
-
James Watson, Kathleen Kelly, Michael Largen, Benjamin Taylor (1978)
The genetic mapping of a defective LPS response gene in C3H/HeJ mice.Journal of immunology, 120 2
-
K. Bender (2005)
ImmunogeneticsGenes and Immunity, 6
-
A. O’Brien, D. Rosenstreich, I. Scher, G. Campbell, R. Macdermott, S. Formal (1980)
Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene.Journal of immunology, 124 1
-
J. Forbes, P. Gros (2003)
Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane.Blood, 102 5
-
D. Portnoy (2005)
Manipulation of innate immunity by bacterial pathogens.Current opinion in immunology, 17 1
-
Chiang Su, J. Mekalanos, David Holden (1999)
In vivo genetic analysis of bacterial virulence.Annual review of microbiology, 53
-
J. Caron, L. Larivière, Mayss Nacache, M. Tam, M. Stevenson, Colin McKerly, P. Gros, D. Malo (2006)
Influence of Slc11a1 on the Outcome of Salmonella enterica Serovar Enteritidis Infection in Mice Is Associated with Th PolarizationInfection and Immunity, 74
-
K. Hoebe, P. Georgel, S. Rutschmann, Xin Du, S. Mudd, K. Crozat, S. Sovath, L. Shamel, T. Hartung, U. Zähringer, B. Beutler (2005)
CD36 is a sensor of diacylglyceridesNature, 433
-
Shiping Zhang, F. McCormack, R. Lévesque, G. O’Toole, G. Lau (2007)
The Flagellum of Pseudomonas aeruginosa Is Required for Resistance to Clearance by Surfactant Protein APLoS ONE, 2
-
N. Jeney, Eberhardt Gúnther, K. Jann (1977)
Mitogenic stimulation of murine spleen cells: relation to susceptibility to Salmonella infectionInfection and Immunity, 15
-
Kaman Chan, Charles Kim, S. Falkow (2005)
Microarray-Based Detection of Salmonella enterica Serovar Typhimurium Transposon Mutants That Cannot Survive in Macrophages and MiceInfection and Immunity, 73
-
Vincent Ng, J. Cox, A. Sousa, J. MacMicking, J. Mckinney (2004)
Role of KatG catalase‐peroxidase in mycobacterial pathogenesis: countering the phagocyte oxidative burstMolecular Microbiology, 52
-
J. Plant, A. Glynn (1976)
Genetics of resistance to infection with Salmonella typhimurium in mice.The Journal of infectious diseases, 133 1
-
Qing Xu, M. Dziejman, J. Mekalanos (2003)
Determination of the transcriptome of Vibrio cholerae during intraintestinal growth and midexponential phase in vitroProceedings of the National Academy of Sciences of the United States of America, 100
-
V. Boyartchuk, K. Broman, Rebecca Mosher, Sarah D’Orazio, M. Starnbach, W. Dietrich (2001)
Multigenic control of Listeria monocytogenes susceptibility in miceNature Genetics, 27
-
J. Growney, William Dietrich (2000)
High-resolution genetic and physical map of the Lgn1 interval in C57BL/6J implicates Naip2 or Naip5 in Legionella pneumophila pathogenesis.Genome research, 10 8
-
Dorothy Concepcion, K. Seburn, G. Wen, W. Frankel, B. Hamilton (2004)
Mutation Rate and Predicted Phenotypic Target Sizes in Ethylnitrosourea-Treated MiceGenetics, 168
-
G. Bancroft, J. Kelly (1994)
Macrophage activation and innate resistance to infection in SCID mice.Immunobiology, 191 4-5
-
N. Brown, M. Wickham, B. Coombes, B. Finlay (2006)
Crossing the Line: Selection and Evolution of Virulence TraitsPLoS Pathogens, 2
-
Johannes Barsig, Stefan Kaufmann (1997)
The mechanism of cell death in Listeria monocytogenes-infected murine macrophages is distinct from apoptosisInfection and Immunity, 65
-
G. Viboud, J. Bliska (2005)
Yersinia outer proteins: role in modulation of host cell signaling responses and pathogenesis.Annual review of microbiology, 59
-
P. Gros, E. Skamene, A. Forget (1981)
Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice.Journal of immunology, 127 6
-
J. Snyder, Brian Haugen, E. Buckles, C. Lockatell, David Johnson, M. Donnenberg, R. Welch, H. Mobley (2004)
Transcriptome of Uropathogenic Escherichia coli during Urinary Tract InfectionInfection and Immunity, 72
-
H. Robson, S. Vas (1972)
Resistance of inbred mice to Salmonella typhimurium.The Journal of infectious diseases, 126 4
-
E. Harvill, P. Cotter, M. Yuk, Jeff Miller (1999)
Probing the Function of Bordetella bronchiseptica Adenylate Cyclase Toxin by Manipulating Host ImmunityInfection and Immunity, 67
-
I Miyairi, VR Tatireddigari, OS Mahdi, LA Rose, RJ Belland, L Lu, RW Williams, GI Byrne (2007)
The p47 GTPases Iigp2 and Irgb10 regulate innate immunity and inflammation to murine Chlamydia psittaci infectionJ Immunol, 179
-
R. Cordoba-Rodriguez, H. Fang, C. Lankford, D. Frucht (2004)
Anthrax Lethal Toxin Rapidly Activates Caspase-1/ICE and Induces Extracellular Release of Interleukin (IL)-1β and IL-18*Journal of Biological Chemistry, 279
-
P. Balachandran, L. Dragone, L. Garrity-Ryan, Armando Lemus, Arthur Weiss, J. Engel (2007)
The ubiquitin ligase Cbl-b limits Pseudomonas aeruginosa exotoxin T-mediated virulence.The Journal of clinical investigation, 117 2
-
V. Boyartchuk, M. Rojas, Bo-Shiun Yan, O. Jobe, N. Hurt, D. Dorfman, D. Higgins, W. Dietrich, I. Kramnik (2004)
The Host Resistance Locus sst1 Controls Innate Immunity to Listeria monocytogenes Infection in Immunodeficient Mice1The Journal of Immunology, 173
-
I. Kramnik, W. Dietrich, P. Demant, B. Bloom (2000)
Genetic control of resistance to experimental infection with virulent Mycobacterium tuberculosis.Proceedings of the National Academy of Sciences of the United States of America, 97 15
-
Ryan O’Connell, Supriya Saha, Sagar Vaidya, K. Bruhn, G. Miranda, B. Zarnegar, Andrea Perry, Bidong Nguyen, T. Lane, T. Taniguchi, Jeff Miller, G. Cheng (2004)
Type I Interferon Production Enhances Susceptibility to Listeria monocytogenes InfectionThe Journal of Experimental Medicine, 200
-
R. Medzhitov, P. Preston-Hurlburt, C. Janeway (1997)
A human homologue of the Drosophila Toll protein signals activation of adaptive immunityNature, 388
-
P. François, C. Garzoni, Manuela Bento, J. Schrenzel (2007)
Comparison of amplification methods for transcriptomic analyses of low abundance prokaryotic RNA sources.Journal of microbiological methods, 68 2
-
Shiping Zhang, Yi Chen, É. Potvin, F. Sanschagrin, R. Lévesque, F. McCormack, G. Lau (2005)
Comparative Signature-Tagged Mutagenesis Identifies Pseudomonas Factors Conferring Resistance to the Pulmonary Collectin SP-APLoS Pathogens, 1
-
Y. Yamamoto, T. Klein, C. Newton, R. Widen, H. Friedman (1988)
Growth of Legionella pneumophila in thioglycolate-elicited peritoneal macrophages from A/J miceInfection and Immunity, 56
-
S. Vidal, M. Tremblay, G. Govoni, S. Gauthier, G. Sebastiani, D. Malo, E. Skamene, M. Olivier, S. Jothy, P. Gros (1995)
The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 geneThe Journal of Experimental Medicine, 182
-
M. Graham, K. Virtaneva, S. Porcella, D. Gardner, R. Long, D. Welty, W. Barry, Claire Johnson, Larye Parkins, F. Wright, J. Musser, J. Musser (2006)
Analysis of the transcriptome of group A Streptococcus in mouse soft tissue infection.The American journal of pathology, 169 3
-
J. MacMicking (2005)
Immune control of phagosomal bacteria by p47 GTPases.Current opinion in microbiology, 8 1
-
Frantisek Supek, L. Supeková, Hannah Nelson, Nathan Nelson (1996)
A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria.Proceedings of the National Academy of Sciences of the United States of America, 93 10
-
E. Diez, Seung-Hwan Lee, S. Gauthier, Z. Yaraghi, M. Tremblay, S. Vidal, P. Gros (2003)
Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophilaNature Genetics, 33
-
DJ Bradley (1974)
Letter: genetic control of natural resistance to Leishmania donovaniNature, 250
-
S. Hitotsumachi, D. Carpenter, W. Russell (1985)
Dose-repetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia.Proceedings of the National Academy of Sciences of the United States of America, 82 19
-
Lauren Logsdon, J. Mecsas (2003)
Requirement of the Yersinia pseudotuberculosis Effectors YopH and YopE in Colonization and Persistence in Intestinal and Lymph TissuesInfection and Immunity, 71
-
D. Merrell, A. Camilli (2002)
Information overload: assigning genetic functionality in the age of genomics and large-scale screening.Trends in microbiology, 10 12
-
E. Meylan, J. Tschopp, M. Karin (2006)
Intracellular pattern recognition receptors in the host responseNature, 442
-
B. Zwilling, L. Vespa, M. Massie (1987)
Regulation of I-A expression by murine peritoneal macrophages: differences linked to the Bcg gene.Journal of immunology, 138 5
-
P. Cuéllar-Mata, N. Jabado, Jun Liu, W. Furuya, B. Finlay, P. Gros, S. Grinstein (2002)
Nramp1 Modifies the Fusion of Salmonella typhimurium-containing Vacuoles with Cellular Endomembranes in Macrophages*The Journal of Biological Chemistry, 277
-
A. Friedlander, R. Bhatnagar, S. Leppla, L. Johnson, Y. Singh (1993)
Characterization of macrophage sensitivity and resistance to anthrax lethal toxinInfection and Immunity, 61
-
J. Plant, A. Glynn (1974)
Natural resistance to Salmonella infection, delayed hypersensitivity and Ir genes in different strains of miceNature, 248
-
S. Chisholm, G. Coaker, B. Day, B. Staskawicz (2006)
Host-Microbe Interactions: Shaping the Evolution of the Plant Immune ResponseCell, 124
-
R. Fleischmann, M. Adams, O. White, R. Clayton, E. Kirkness, A. Kerlavage, C. Bult, J. Tomb, B. Dougherty, J. Merrick, K. Mckenney, G. Sutton, W. FitzHugh, C. Fields, Jeannie Gocyne, J. Scott, R. Shirley, Li-ing Liu, A. Glodek, J. Kelley, J. Weidman, C. Phillips, T. Spriggs, Eva Hedblom, M. Cotton (1995)
Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.Science, 269 5223
-
P. Dunn, R North (1991)
Early gamma interferon production by natural killer cells is important in defense against murine listeriosisInfection and Immunity, 59
-
E. Wright, S. Goodart, J. Growney, V. Hadinoto, M. Endrizzi, E. Long, Keyvan Sadigh, Andrew Abney, I. Bernstein-Hanley, W. Dietrich (2003)
Naip5 Affects Host Susceptibility to the Intracellular Pathogen Legionella pneumophilaCurrent Biology, 13
-
N. Jabado, A. Jankowski, Samuel Dougaparsad, V. Picard, S. Grinstein, P. Gros (2000)
Natural Resistance to Intracellular InfectionsThe Journal of Experimental Medicine, 192
-
A. Coutinho, T. Meo (1978)
Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr miceImmunogenetics, 7
-
Edward Miao, C. Alpuche-Aranda, Monica Dors, April Clark, M. Bader, Samuel Miller, A. Aderem (2006)
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via IpafNature Immunology, 7
-
I. Bernstein-Hanley, Zarine Balsara, W. Ulmer, Jörn Coers, M. Starnbach, William Dietrich (2006)
Genetic analysis of susceptibility to Chlamydia trachomatis in mouseGenes and Immunity, 7
-
Eric Boyden, W. Dietrich (2006)
Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxinNature Genetics, 38
-
B Lemaitre, E Nicolas, L Michaut, JM Reichhart, JA Hoffmann (1996)
The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adultsCell, 86
-
D. Weiss, Anna Brotcke, T. Henry, Jeffrey Margolis, Kaman Chan, D. Monack (2007)
In vivo negative selection screen identifies genes required for Francisella virulenceProceedings of the National Academy of Sciences, 104
-
A. Klarsfeld, P. Goossens, P. Cossart (1994)
Five Listeria monocytogenes genes preferentially expressed in infected mammalian cells: plcA, purH, purD, pyrE and an arginine ABC transporter gene, arpJMolecular Microbiology, 13
-
Sui Huang, W. Hendriks, A. Althage, S. Hemmi, H. Bluethmann, R. Kamijo, J. Vilček, R. Zinkernagel, M. Aguet (1993)
Immune response in mice that lack the interferon-gamma receptor.Science, 259 5102
-
D. Zamboni, Koichi Kobayashi, Koichi Kobayashi, T. Kohlsdorf, Y. Ogura, E. Long, R. Vance, K. Kuida, S. Mariathasan, V. Dixit, R. Flavell, W. Dietrich, C. Roy (2006)
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infectionNature Immunology, 7
-
Betty Yan, A. Kirby, Y. Shebzukhov, M. Daly, I. Kramnik (2006)
Genetic architecture of tuberculosis resistance in a mouse model of infectionGenes and Immunity, 7
-
D. Bradley, J. Kirkley (1977)
Regulation of Leishmania populations within the host. I. the variable course of Leishmania donovani infections in mice.Clinical and experimental immunology, 30 1
-
K. Tabeta, K. Hoebe, E. Janssen, Xin Du, P. Georgel, K. Crozat, S. Mudd, N. Mann, S. Sovath, Jason Goode, L. Shamel, A. Herskovits, D. Portnoy, M. Cooke, L. Tarantino, T. Wiltshire, B. Steinberg, S. Grinstein, B. Beutler (2006)
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9Nature Immunology, 7
-
J. Coers, R. Vance, Mary Fontana, W. Dietrich (2007)
Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathwaysCellular Microbiology, 9
-
R. Medzhitov, C. Janeway (1997)
Innate Immunity: The Virtues of a Nonclonal System of RecognitionCell, 91
-
K. Darwin, S. Ehrt, J. Gutiérrez-Ramos, N. Weich, C. Nathan (2003)
The Proteasome of Mycobacterium tuberculosis Is Required for Resistance to Nitric OxideScience, 302
-
(2006)
The plant immune system -
J. Buer, R. Balling (2003)
Mice, microbes and models of infectionNature Reviews Genetics, 4
-
A. Camilli, J. Mekalanos (1995)
Use of recombinase gene fusions to identify Vibrio cholerae genes induced during infectionMolecular Microbiology, 18
-
Jyothi Rengarajan, B. Bloom, E. Rubin (2005)
Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages.Proceedings of the National Academy of Sciences of the United States of America, 102 23
-
T. Ren, D. Zamboni, C. Roy, W. Dietrich, R. Vance (2006)
Flagellin-Deficient Legionella Mutants Evade Caspase-1- and Naip5-Mediated Macrophage ImmunityPLoS Pathogens, 2
-
Victoria Auerbuch, D. Brockstedt, Nicole Meyer-Morse, M. O’Riordan, D. Portnoy (2004)
Mice Lacking the Type I Interferon Receptor Are Resistant to Listeria monocytogenesThe Journal of Experimental Medicine, 200
-
W. Day, S. Rasmussen, B. Carpenter, S. Peterson, A. Friedlander (2007)
Microarray Analysis of Transposon Insertion Mutations in Bacillus anthracis: Global Identification of Genes Required for Sporulation and GerminationJournal of Bacteriology, 189
-
S. Joshi, A. Pandey, Nicole Capite, S. Fortune, E. Rubin, C. Sassetti (2006)
Characterization of mycobacterial virulence genes through genetic interaction mapping.Proceedings of the National Academy of Sciences of the United States of America, 103 31
-
D. Hackam, O. Rotstein, Wei-jian Zhang, S. Gruenheid, P. Gros, S. Grinstein (1998)
Host Resistance to Intracellular Infection: Mutation of Natural Resistance-associated Macrophage Protein 1 (Nramp1) Impairs Phagosomal AcidificationThe Journal of Experimental Medicine, 188
-
I. Bernstein-Hanley, J. Coers, Zarine Balsara, G. Taylor, M. Starnbach, W. Dietrich (2006)
The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in miceProceedings of the National Academy of Sciences, 103
-
A. Rietsch, M. Wolfgang, J. Mekalanos (2004)
Effect of Metabolic Imbalance on Expression of Type III Secretion Genes in Pseudomonas aeruginosaInfection and Immunity, 72
-
E. Skamene, P. Gros, A. Forget, P. Kongshavn, Carole Charles, B. Taylor (1982)
Genetic regulation of resistance to intracellular pathogensNature, 297
-
J. Roberts, J. Watters, J. Ballard, W. Dietrich (1998)
Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11Molecular Microbiology, 29
-
A. Vázquez-Torres, Yisheng Xu, J. Jones-Carson, D. Holden, Scott Lucia, M. Dinauer, P. Mastroeni, F. Fang (2000)
Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase.Science, 287 5458
-
J. Growney, J. Scharf, L. Kunkel, W. Dietrich (2000)
Evolutionary divergence of the mouse and human Lgn1/SMA repeat structures.Genomics, 64 1
-
M. Hensel, J. Shea, Colin Gleeson, Michael Jones, E. Dalton, D. Holden (1995)
Simultaneous identification of bacterial virulence genes by negative selection.Science, 269 5222
-
C. Tripp, M. Gately, J. Hakimi, Ping Ling, E. Unanue (1994)
Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma.Journal of immunology, 152 4
-
P. Papathanasiou, C. Goodnow (2005)
Connecting mammalian genome with phenome by ENU mouse mutagenesis: gene combinations specifying the immune system.Annual review of genetics, 39
-
H. Gunshin, B. Mackenzie, U. Berger, Yoshimi Gunshin, M. Romero, W. Boron, S. Nussberger, J. Gollan, M. Hediger (1997)
Cloning and characterization of a mammalian proton-coupled metal-ion transporterNature, 388
-
M. Mahan, J. Tobias, J. Slauch, J. Slauch, P. Hanna, R. Collier, J. Mekalanos (1995)
Antibiotic-based selection for bacterial genes that are specifically induced during infection of a host.Proceedings of the National Academy of Sciences of the United States of America, 92 3
-
J. Mecsas (2002)
Use of signature-tagged mutagenesis in pathogenesis studies.Current opinion in microbiology, 5 1
-
S. Vidal, Danielle Malo, Kyle Vogan, Emil Skamene, Philippe Gros (1993)
Natural resistance to infection with intracellular parasites: Isolation of a candidate for BcgCell, 73
-
K. Tosh, S. Campbell, K. Fielding, J. Sillah, B. Bah, P. Gustafson, K. Manneh, I. Lisse, G. Sirugo, S. Bennett, P. Aaby, K. McAdam, O. Bah‐sow, C. Lienhardt, I. Kramnik, A. Hill (2006)
Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West AfricaProceedings of the National Academy of Sciences, 103
-
M. Lurie, P. Zappasodi, A. Dannenberg, G. Weiss (1952)
On the mechanism of genetic resistance to tuberculosis and its mode of inheritance.American journal of human genetics, 4 4
-
M. Saleh, J. Mathison, Melissa Wolinski, S. Bensinger, Patrick Fitzgerald, N. Droin, R. Ulevitch, D. Green, D. Nicholson (2006)
Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient miceNature, 440
-
A. Amer, M. Swanson (2005)
Autophagy is an immediate macrophage response to Legionella pneumophilaCellular Microbiology, 7
-
Jonathan Lawson, C. Lyons, S. Johnston (2006)
Expression profiling of Yersinia pestis during mouse pulmonary infection.DNA and cell biology, 25 11
-
William Dietrich, Deborah Damron, R. Isberg, Eric Lander, Michele Swanson (1995)
Lgn1, a gene that determines susceptibility to Legionella pneumophila, maps to mouse chromosome 13.Genomics, 26 3
-
H. Pan, Bo-Shiun Yan, M. Rojas, Y. Shebzukhov, Hongwei Zhou, L. Kobzik, D. Higgins, M. Daly, B. Bloom, I. Kramnik (2005)
Ipr1 gene mediates innate immunity to tuberculosisNature, 434
-
A. Poltorak, Xiaolong He, I. Smirnova, Mu-ya Liu, C. Huffel, Xin Du, D. Birdwell, Erica Alejos, Maria Silva, C. Galanos, M. Freudenberg, P. Ricciardi-Castagnoli, Betsy Layton, B. Beutler (1998)
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.Science, 282 5396
-
N. Salama, C. Manoil (2006)
Seeking completeness in bacterial mutant hunts.Current opinion in microbiology, 9 3
- Publisher
- Springer Journals
- Copyright
- Copyright © 2007 by Springer-Verlag
- Subject
- Biomedicine; Cell Biology; Allergology; Immunology
- ISSN
- 0093-7711
- eISSN
- 1432-1211
- DOI
- 10.1007/s00251-007-0248-0
- pmid
- 17874090
- Publisher site
- See Article on Publisher Site
Abstract
The interaction of bacterial pathogens with their hosts’ innate immune systems can be extremely complex and is often difficult to disentangle experimentally. Using mouse models of bacterial infections, several laboratories have successfully applied genetic approaches to identify novel host genes required for innate immune defense. In addition, a variety of creative bacterial genetic schemes have been developed to identify key bacterial genes involved in triggering or evading host immunity. In cases where both the host and pathogen are amenable to genetic manipulation, a combination of host and pathogen genetic approaches can be used. Focusing on bacterial infections of mice, this review summarizes the benefits and limitations of applying genetic analysis to the study of host–pathogen interactions. In particular, we consider how prokaryotic and eukaryotic genetic strategies can be combined, or “squared,” to yield new insights in host–pathogen biology.
Journal
Immunogenetics – Springer Journals
Published: Sep 14, 2007