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Natural resistance to Salmonella infection, delayed hypersensitivity and Ir genes in different strains of mice

Natural resistance to Salmonella infection, delayed hypersensitivity and Ir genes in different... THE development of immunity to an intracellular bacterial infection such as that produced by Salmonella typhimurium in mice can be followed by the fall in the numbers of living bacteria in the liver and spleen. Resistance to infection appears at about the same time as delayed hypersensitivity to appropriate antigens of the infecting organisms and both may be taken as indicators of a cell-mediated immune response1. Inbred mouse strains differ widely in their resistance to salmonella infections and one possible explanation is that they differ in their ability to produce cell-mediated immune responses in general. This has been tested by comparing the degrees of delayed hypersensitivity detectable in different strains of mice sensitised with a number of unrelated antigens. The results discussed here disprove the hypothesis but suggest a more interesting one. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Natural resistance to Salmonella infection, delayed hypersensitivity and Ir genes in different strains of mice

PLANT, J.; GLYNN, A. A.
Nature , Volume 248 (5446) – Mar 22, 1974
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References (10)

Publisher
Springer Journals
Copyright
Copyright © 1974 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/248345a0
Publisher site
See Article on Publisher Site

Abstract

THE development of immunity to an intracellular bacterial infection such as that produced by Salmonella typhimurium in mice can be followed by the fall in the numbers of living bacteria in the liver and spleen. Resistance to infection appears at about the same time as delayed hypersensitivity to appropriate antigens of the infecting organisms and both may be taken as indicators of a cell-mediated immune response1. Inbred mouse strains differ widely in their resistance to salmonella infections and one possible explanation is that they differ in their ability to produce cell-mediated immune responses in general. This has been tested by comparing the degrees of delayed hypersensitivity detectable in different strains of mice sensitised with a number of unrelated antigens. The results discussed here disprove the hypothesis but suggest a more interesting one.

Journal

Nature – Springer Journals

Published: Mar 22, 1974

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