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P ROTEIN AND L IPID R EQUIREMENTS FOR E NDOCYTOSIS

P ROTEIN AND L IPID R EQUIREMENTS FOR E NDOCYTOSIS ▪ Abstract Genetic and biochemical studies in yeast and animal cells have led to the identification of many components required for endocytosis. In this review, we summarize our understanding of the endocytic machinery with an emphasis on the proteins regulating the internalization step of endocytosis and endosome fusion. Even though the overall endocytic machinery appears to be conserved between yeast and animals, clear differences exist. We also discuss the roles of phosphoinositides, sterols, and sphingolipid precursors in endocytosis, because in addition to proteins, these lipids have emerged as important determinants in the spatial and most likely temporal specificity of endocytic membrane trafficking events. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Genetics Annual Reviews

P ROTEIN AND L IPID R EQUIREMENTS FOR E NDOCYTOSIS

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References (271)

Publisher
Annual Reviews
Copyright
Copyright © 2000 by Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4197
eISSN
1545-2948
DOI
10.1146/annurev.genet.34.1.255
pmid
11092829
Publisher site
See Article on Publisher Site

Abstract

▪ Abstract Genetic and biochemical studies in yeast and animal cells have led to the identification of many components required for endocytosis. In this review, we summarize our understanding of the endocytic machinery with an emphasis on the proteins regulating the internalization step of endocytosis and endosome fusion. Even though the overall endocytic machinery appears to be conserved between yeast and animals, clear differences exist. We also discuss the roles of phosphoinositides, sterols, and sphingolipid precursors in endocytosis, because in addition to proteins, these lipids have emerged as important determinants in the spatial and most likely temporal specificity of endocytic membrane trafficking events.

Journal

Annual Review of GeneticsAnnual Reviews

Published: Dec 1, 2000

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