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I NV I T E D CO MME NT AR Y The Pathogenesis of Barrett’s Esophagus: A Process In Continuum or Discontinuum Rebecca C. Fitzgerald, MD, MRCP and Michael J. G. Farthing, MD, FRCP Address 30% of patients with Barrett’s do not have heartburn or *Faculty of Medicine, University of Glasgow, Southpark Terrace, regurgitation, and the majority of cases remain undiag- Glasgow G12 8LG, Scotland. nosed in the community. The estimated diagnosed preva- Current Gastroenterology Reports 2000, 2:421–424 lence of Barrett’s is 22.6 per 100,000; however, the actual Current Science Inc. ISSN 1522–8037 (non-clinically diagnosed) prevalence is estimated to be as Copyright © 2000 by Current Science Inc. high as one in 250 of the total community and one in 20 of adults with frequent reflux symptoms [10]. In The pathogenesis of Barrett’s esophagus has not been clearly contrast, approximately a third of patients with reflux defined although it is usually associated with gastro- symptoms have esophagitis, which varies worldwide from esophageal reflux disease (GERD) and is more common in 0.5% to 22.8% of patients having an upper gastrointestinal white male patients [1,2]. The established view is that the endoscopy [7]. esophageal epithelial response to reflux depends upon its
Current Gastroenterology Reports – Springer Journals
Published: May 15, 2000
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