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Expression of Epidermal Growth Factor, Transforming Growth Factor Alpha and Their Receptor in Gastro-Oesophageal Diseases

Expression of Epidermal Growth Factor, Transforming Growth Factor Alpha and Their Receptor in... This article is a review of aspects of the expression of the regulatory peptides; epidermal growth factor (EGF), transforming growth factor alpha (TGF-α), and their receptor (EGF-R) in the epithelium of the human oesophagus and stomach in health and disease. It has become clear that TGF-α has increased expression in metaplastic, dysplastic and neoplastic tissue of the oesophagus compared with normal mucosa. The degree of abnormal expression becomes more marked as dysplasia increases. TGF-α expression is also increased in gastric neoplasias. EGF has a different pattern of expression, being decreased in oesophagitis and increased in gastritis. Although EGF is present in Barrett’s oesophagitis, the expression of EGF does not discriminate between dysplastic and neoplastic epithelium. EGF-R is normally expressed on all gastrointestinal epithelia, but its expression is increased in Barrett’s epithelium, as well as in adenocarcinomas of the oesophagus and the stomach. The two peptides bind to their receptors on the mucosal cell membranes, and the co-expression of peptide and receptor is positively associated with varying degrees of cellular proliferation. The density of receptor expression may modulate the proliferative stimulus, leading to either mitogenic (regulated) or oncogenic (unregulated) growth. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Digestive Diseases Karger

Expression of Epidermal Growth Factor, Transforming Growth Factor Alpha and Their Receptor in Gastro-Oesophageal Diseases

Jankowski, J.; Hopwood, D.; Wormsley, K.G.
Digestive Diseases , Volume 11 (1): 11 – Jan 1, 1993
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Publisher
Karger
Copyright
© 1993 S. Karger AG, Basel
ISSN
0257-2753
eISSN
1421-9875
DOI
10.1159/000171396
Publisher site
See Article on Publisher Site

Abstract

This article is a review of aspects of the expression of the regulatory peptides; epidermal growth factor (EGF), transforming growth factor alpha (TGF-α), and their receptor (EGF-R) in the epithelium of the human oesophagus and stomach in health and disease. It has become clear that TGF-α has increased expression in metaplastic, dysplastic and neoplastic tissue of the oesophagus compared with normal mucosa. The degree of abnormal expression becomes more marked as dysplasia increases. TGF-α expression is also increased in gastric neoplasias. EGF has a different pattern of expression, being decreased in oesophagitis and increased in gastritis. Although EGF is present in Barrett’s oesophagitis, the expression of EGF does not discriminate between dysplastic and neoplastic epithelium. EGF-R is normally expressed on all gastrointestinal epithelia, but its expression is increased in Barrett’s epithelium, as well as in adenocarcinomas of the oesophagus and the stomach. The two peptides bind to their receptors on the mucosal cell membranes, and the co-expression of peptide and receptor is positively associated with varying degrees of cellular proliferation. The density of receptor expression may modulate the proliferative stimulus, leading to either mitogenic (regulated) or oncogenic (unregulated) growth.

Journal

Digestive Diseases – Karger

Published: Jan 1, 1993

Keywords: Oesophageal cancer; Gastritis; Gastric cancer; Transforming growth factor alpha; Barrett’s oesophagus; Epidermal growth factor; Epidermal growth factor receptor; Oesophagitis

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