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- Publisher
- Oxford University Press
- Copyright
- © Published by Oxford University Press.
- ISSN
- 0305-7453
- eISSN
- 1460-2091
- DOI
- 10.1093/jac/dkf176
- Publisher site
- See Article on Publisher Site
Abstract
The study was a prospective observational trial carried out to assess the clarithromycin–digoxin interaction in elderly patients chronically taking digoxin. Digoxin concentrations were determined before and after concomitant treatment with clarithromycin. A Bayesian approach was used to calculate digoxin pharmacokinetics. In the seven patients who were studied there was a significant increase in digoxin concentration after 4–7 days of clarithromycin treatment; digoxin clearance and elimination rate constant were 56–60% lower and elimination half-life was 82% longer. The pharmacokinetic clarithromycin–digoxin interaction in the elderly may be much more frequent than has been assumed up to now.
Journal
Journal of Antimicrobial Chemotherapy – Oxford University Press
Published: Oct 1, 2002