Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/taylor-francis/role-of-the-serotonin-system-in-adhd-treatment-implications-PSCU0nPIR0
References (198)
-
J. Rapoport, P. Quinn, N. Scribanu, D. Murphy (1974)
Platelet Serotonin of Hyperactive School Age BoysBritish Journal of Psychiatry, 125
-
C. Winstanley, D. Eagle, T. Robbins (2006)
Behavioral models of impulsivity in relation to ADHD: Translation between clinical and preclinical studiesClinical Psychology Review, 26
-
M. Tseng, A. Henderson, Susanna Chow, G. Yao (2004)
Relationship between motor proficiency, attention, impulse, and activity in children with ADHDDevelopmental Medicine & Child Neurology, 46
-
R. Oades (1985)
The role of noradrenaline in tuning and dopamine in switching between signals in the CNSNeuroscience & Biobehavioral Reviews, 9
-
S. Curran, S. Purcell, I. Craig, P. Asherson, P. Sham (2005)
The serotonin transporter gene as a QTL for ADHDAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 134B
-
A. Villiers, V. Russell, T. Sagvolden, A. Searson, A. Jaffer, J. Taljaard (1995)
β2 Mediated inhibition of [3H]dopamine release from nucleus accumbens slices and monoamine levels in a rat model for attention-deficit hyperactivity disorderNeurochemical Research, 20
-
R. Oades, B. Roepcke, R. Schepker (1996)
A test of conditioned blocking and its development in childhood and adolescence : Relationship to personality and monoamine metabolismDevelopmental Neuropsychology, 12
-
M. Druse, R. Gillespie, N. Tajuddin, M. Rich (2007)
S100B-mediated protection against the pro-apoptotic effects of ethanol on fetal rhombencephalic neuronsBrain Research, 1150
-
N. Varney (1996)
Psychopharmacology: The Fourth Generation of Progress.Psyccritiques, 41
-
Sabiha Barot, S. Ferguson, J. Neumaier (2007)
5‐HT1B receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaineEuropean Journal of Neuroscience, 25
-
Jun Li, Yufeng Wang, R. Zhou, Hao-bo Zhang, Li Yang, B. Wang, S. Faraone (2007)
Association between polymorphisms in serotonin transporter gene and attention deficit hyperactivity disorder in Chinese Han subjectsAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 144B
-
C. Carver, Christopher Miller (2006)
Relations of serotonin function to personality: Current views and a key methodological issuePsychiatry Research, 144
-
(1998)
Event-related potentials and clinical response to serotonin agonists in patients with affective disorders -
B. Jacobs, E. Azmitia (1992)
Structure and function of the brain serotonin system.Physiological reviews, 72 1
-
(2006)
Effect of acute and chronic tryptophan depletion on serotonergic metabolism and receptors in the rat brain -
J. Evenden, C. Ryan (1999)
The pharmacology of impulsive behaviour in rats VI: the effects of ethanol and selective serotonergic drugs on response choice with varying delays of reinforcementPsychopharmacology, 146
-
J. Quist, C. Barr, R. Schachar, W. Roberts, M. Malone, R. Tannock, V. Basile, J. Beitchman, J. Kennedy (2003)
The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorderMolecular Psychiatry, 8
-
A. Thapar, K. Langley, P. Asherson, M. Gill (2007)
Gene–environment interplay in attention-deficit hyperactivity disorder and the importance of a developmental perspectiveBritish Journal of Psychiatry, 190
-
K. Sheehan, N. Lowe, A. Kirley, C. Mullins, M. Fitzgerald, M. Gill, Z. Hawi (2005)
Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHDMolecular Psychiatry, 10
-
R. Oades, A. Dittmann-Balçar, R. Schepker, C. Eggers, D. Zerbin (1996)
Auditory event-related potentials (ERPs) and mismatch negativity (MMN) in healthy children and those with attention-deficit or tourette/tic symptomsBiological Psychology, 43
-
Mehlman Pt, G. Westergaard, B. Hoos, F. Sallee, S. Marsh, S. Suomi, Markku Linnoila, J. Higley (2000)
CSF 5-HIAA and Nighttime Activity in Free-Ranging PrimatesNeuropsychopharmacology, 22
-
R. Loose, C. Kaufmann, D. Auer, K. Lange (2003)
Human prefrontal and sensory cortical activity during divided attention tasksHuman Brain Mapping, 18
-
A. Bonnin, M. Torii, Lilly Wang, P. Rakic, P. Levitt (2007)
Serotonin modulates the response of embryonic thalamocortical axons to netrin-1Nature Neuroscience, 10
-
B. Leonard, D. McCartan, John White, D. King (2004)
Methylphenidate: a review of its neuropharmacological, neuropsychological and adverse clinical effectsHuman Psychopharmacology: Clinical and Experimental, 19
-
Andrea Burgio-Murphy, R. Klorman, S. Shaywitz, J. Fletcher, K. Marchione, J. Holahan, K. Stuebing, J. Thatcher, B. Shaywitz (2007)
Error-related event-related potentials in children with attention-deficit hyperactivity disorder, oppositional defiant disorder, reading disorder, and math disorderBiological Psychology, 75
-
P. Whitaker-Azmitia, E. Azmitia (1994)
Astroglial 5-HT1a receptors and S-100 beta in development and plasticity.Perspectives on developmental neurobiology, 2 3
-
M. O’Neill, C. Heron-Maxwell, G. Shaw (1999)
5-HT2 Receptor Antagonism Reduces Hyperactivity Induced by Amphetamine, Cocaine, and MK-801 But Not D1 Agonist C-APBPharmacology Biochemistry and Behavior, 63
-
M. Döpfner, M. Faraone, S. Rothenberger, T. Banaschewski, D. Coghill, P. Santosh, A. Zuddas, P. Asherson, J. Buitelaar, M. Danckaerts, M. Döpfner, S. Faraone, A. Rothenberger, J. Sergeant, H. Steinhausen, E. Sonuga-Barke, E. Taylor (2006)
Long-acting medications for the hyperkinetic disorders -
R. Oades (2011)
Connections between studies of the neurobiology of attention, psychotic processes and event-related potentials.Electroencephalography and clinical neurophysiology. Supplement, 44
-
C. Winstanley, D. Theobald, J. Dalley, R. Cardinal, T. Robbins (2006)
Double dissociation between serotonergic and dopaminergic modulation of medial prefrontal and orbitofrontal cortex during a test of impulsive choice.Cerebral cortex, 16 1
-
B. Dev, L. Philip (1996)
Extracellular catechol and indole turnover in the nucleus of the solitary tract of spontaneously hypertensive and Wistar-Kyoto normotensive rats in response to drug-induced changes in arterial blood pressureBrain Research Bulletin, 40
-
K. Rubia, F. Lee, A. Cleare, N. Tunstall, C. Fu, M. Brammer, P. McGuire (2005)
Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRIPsychopharmacology, 179
-
P. Nathan, R. Segrave, K. Phan, B. O’Neill, R. Croft (2006)
Direct evidence that acutely enhancing serotonin with the selective serotonin reuptake inhibitor citalopram modulates the loudness dependence of the auditory evoked potential (LDAEP) marker of central serotonin functionHuman Psychopharmacology: Clinical and Experimental, 21
-
T. Uehara, T. Sumiyoshi, T. Matsuoka, H. Itoh, M. Kurachi (2006)
Role of 5-HT1A receptors in the modulation of stress-induced lactate metabolism in the medial prefrontal cortex and basolateral amygdalaPsychopharmacology, 186
-
A. Gobert, J. Rivet, V. Audinot, A. Newman-Tancredi, L. Cistarelli, M. Millan (1998)
Simultaneous quantification of serotonin, dopamine and noradrenaline levels in single frontal cortex dialysates of freely-moving rats reveals a complex pattern of reciprocal auto- and heteroreceptor-mediated control of releaseNeuroscience, 84
-
Yun-Ai Su, T. Si, Dongfeng Zhou, Chunmei Guo, Xiao-Dong Wang, Yang Yang, L. Shu, Jian-hui Liang (2007)
Risperidone attenuates MK-801-induced hyperlocomotion in mice via the blockade of serotonin 5-HT 2A/2C receptors.European journal of pharmacology, 564 1-3
-
U. Hegerl, G. Juckel (1994)
Auditory Evoked Dipole Source Activity: Indicator of Central Serotonergic Dysfunction in Psychiatric Patients?Pharmacopsychiatry, 27
-
E. Paolucci, N. Berretta, A. Tozzi, G. Bernardi, N. Mercuri (2003)
Depression of mGluR‐mediated IPSCs by 5‐HT in dopamine neurons of the rat substantia nigra pars compactaEuropean Journal of Neuroscience, 18
-
K. Varnäs, C. Halldin, V. Pike, H. Hall (2003)
Distribution of 5-HT4 receptors in the postmortem human brain—an autoradiographic study using [125I]SB 207710European Neuropsychopharmacology, 13
-
L. Hurley, G. Pollak (1999)
Serotonin Differentially Modulates Responses to Tones and Frequency-Modulated Sweeps in the Inferior ColliculusThe Journal of Neuroscience, 19
-
J. Dalley, D. Theobald, D. Eagle, F. Passetti, T. Robbins (2002)
Deficits in Impulse Control Associated with Tonically-elevated Serotonergic Function in Rat Prefrontal CortexNeuropsychopharmacology, 26
-
S. Walitza, T. Renner, A. Dempfle, Kerstin Konrad, C. Wewetzer, A. Halbach, B. Herpertz-Dahlmann, Helmut Remschmidt, J. Smidt, M. Linder, L. Flierl, U. Knölker, S. Friedel, H. Schäfer, Cornelius Gross, Johannes Hebebrand, A. Warnke, K. Lesch (2005)
Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorderMolecular Psychiatry, 10
-
S. Stocker, M. Muldoon, A. Sved (2003)
Blunted Fenfluramine-Evoked Prolactin Secretion in Hypertensive RatsHypertension: Journal of the American Heart Association, 42
-
Z. Hawi, M. Dring, A. Kirley, D. Foley, L. Kent, N. Craddock, P. Asherson, S. Curran, A. Gould, S. Richards, D. Lawson, H. Pay, D. Turic, K. Langley, M. Owen, M. O'Donovan, A. Thapar, M. Fitzgerald, M. Gill (2001)
Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT1B receptor gene in 273 nuclear families from a multi-centre sampleMolecular Psychiatry, 7
-
One of a useful series on the biological bases underlying impulsivity in animals -
P. Hoffmann, M. Elam, P. Thoren, S. Hjorth (1994)
Effects of long-lasting voluntary running on the cerebral levels of dopamine, serotonin and their metabolites in the spontaneously hypertensive rat.Life sciences, 54 13
-
(2006)
Cerebral Cortex doi:10.1093/cercor/bhj120 Cognitive Inflexibility after Prefrontal Serotonin Depletion Is Behaviorally and Neurochemically Specific -
P. Knott, V. Haroutunian, L. Bierer, D. Perl, Michael Handler, M. DeLeon, R. Yang, K. Davis (1989)
Correlations post-mortem between ventricular CSF and cortical tissue concentrations of MHPG, 5-HIAA and HVA in Alzheimer's diseaseBiological Psychiatry, 25
-
M. Schmitz, Daniela Denardin, Tatiana Silva, T. Pianca, M. Hutz, S. Faraone, L. Rohde (2006)
Smoking during pregnancy and attention-deficit/hyperactivity disorder, predominantly inattentive type: a case-control study.Journal of the American Academy of Child and Adolescent Psychiatry, 45 11
-
C. Winstanley, J. Dalley, D. Theobald, T. Robbins (2003)
Global 5-HT depletion attenuates the ability of amphetamine to decrease impulsive choice on a delay-discounting task in ratsPsychopharmacology, 170
-
P. Magistretti, Olivier Sorg, Naichen Yu, Jean-Luc Martin, L. Pellerin (1993)
Neurotransmitters regulate energy metabolism in astrocytes: implications for the metabolic trafficking between neural cells.Developmental neuroscience, 15 3-5
-
H. Bhagavan, M. Coleman, D. Coursin (1975)
The effect of pyridoxine hydrochloride on blood serotonin and pyridoxal phosphate contents in hyperactive children.Pediatrics, 55 3
-
F. Côté, C. Fligny, E. Bayard, J. Launay, M. Gershon, J. Mallet, G. Vodjdani (2007)
Maternal serotonin is crucial for murine embryonic developmentProceedings of the National Academy of Sciences, 104
-
R. Káradóttir, David Attwell (2007)
Neurotransmitter receptors in the life and death of oligodendrocytesNeuroscience, 145
-
R. Oades (1987)
Attention deficit disorder with hyperactivity (ADDH): The contribution of catecholaminergic activityProgress in Neurobiology, 29
-
R. Barry, A. Clarke, R. McCarthy, M. Selikowitz (2006)
EEG predictors of good response to Imipramine Hydrochloride in children with attention deficit/hyperactivity disorder -
I. Elgen, S. Bruarøy, L. Laegreid (2007)
Lack of recognition and complexity of foetal alcohol neuroimpairmentsActa Pædiatrica, 96
-
A. Ickowicz, Yu Feng, K. Wigg, J. Quist, T. Pathare, W. Roberts, M. Malone, R. Schachar, R. Tannock, J. Kennedy, C. Barr (2007)
The serotonin receptor HTR1B: Gene polymorphisms in attention deficit hyperactivity disorderAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 144B
-
James Satterfield, A. Schell, Thomas Nicholas (1994)
Preferential neural processing of attended stimuli in attention-deficit hyperactivity disorder and normal boys.Psychophysiology, 31 1
-
K. Domschke, K. Sheehan, N. Lowe, A. Kirley, C. Mullins, Roderick O'sullivan, C. Freitag, T. Becker, J. Conroy, M. Fitzgerald, M. Gill, Z. Hawi (2005)
Association analysis of the monoamine oxidase A and B genes with attention deficit hyperactivity disorder (ADHD) in an Irish sample: Preferential transmission of the MAO‐A 941G allele to affected childrenAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 134B
-
Jun Li, Yufeng Wang, R. Zhou, Hao-bo Zhang, Li Yang, Bin Wang, S. Faraone (2006)
Association between polymorphisms in serotonin 2C receptor gene and attention-deficit/hyperactivity disorder in Han Chinese subjectsNeuroscience Letters, 407
-
B. Birmaher, Michael Stanley, Laurence Greenhill, Janet Twomey, Antigony Gavrilescu, Harris Rabinovich (1990)
Platelet imipramine binding in children and adolescents with impulsive behavior.Journal of the American Academy of Child and Adolescent Psychiatry, 29 6
-
(1975)
Facilitation and inhibition in the processing of signals. In: Attention and Performance -
F. Saudou, D. Amara, A. Dierich, M. Lemeur, S. Ramboz, L. Ségu, M. Buhot, R. Hen (1994)
Enhanced aggressive behavior in mice lacking 5-HT1B receptor.Science, 265 5180
-
R. Oades (2000)
Differential measures of ‘sustained attention’ in children with attention-deficit/hyperactivity or tic disorders: relations to monoamine metabolismPsychiatry Research, 93
-
Jun Li, Yufeng Wang, R. Zhou, B. Wang, Hao-bo Zhang, Li Yang, S. Faraone (2006)
Association of attention-deficit/hyperactivity disorder with serotonin 4 receptor gene polymorphisms in Han Chinese subjectsNeuroscience Letters, 401
-
Aaron Hervey, J. Epstein, J. Curry (2004)
Neuropsychology of adults with attention-deficit/hyperactivity disorder: a meta-analytic review.Neuropsychology, 18 3
-
M. Reuter, U. Ott, D. Vaitl, J. Hennig (2007)
Impaired Executive Control Is Associated with a Variation in the Promoter Region of the Tryptophan Hydroxylase 2 GeneJournal of Cognitive Neuroscience, 19
-
• Important animal study examining the role of 5-HT in impulsivity -
C. Winstanley, D. Theobald, J. Dalley, T. Robbins (2005)
Interactions between Serotonin and Dopamine in the Control of Impulsive Choice in Rats: Therapeutic Implications for Impulse Control DisordersNeuropsychopharmacology, 30
-
K. Langley, A. Payton, M. Hamshere, H. Pay, D. Lawson, D. Turic, W. Ollier, Jane Worthington, M. Owen, M. O’Donovan, A. Thapar (2003)
No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorderPsychiatric Genetics, 13
-
G. Seeger, P. Schloss, Martin Schmidt, Almut Rüter-Jungfleisch, F. Henn (2004)
Gene–environment interaction in hyperkinetic conduct disorder (HD + CD) as indicated by season of birth variations in dopamine receptor (DRD4) gene polymorphismNeuroscience Letters, 366
-
M. Irwin, K. Belendiuk, K. McCloskey, D. Freedman (1981)
Tryptophan metabolism in children with attentional deficit disorder.The American journal of psychiatry, 138 8
-
V. Micale, G. Leggio, C. Mazzola, F. Drago (2006)
Cognitive effects of SL65.0155, a serotonin 5-HT4 receptor partial agonist, in animal models of amnesiaBrain Research, 1121
-
F. Castellanos, J. Elia, Markus Kruesi, W. Marsh, C. Gulotta, W. Potter, G. Ritchie, S. Hamburger, J. Rapoport (1996)
Cerebrospinal Fluid Homovanillic Acid Predicts Behavioral Response to Stimulants in 45 Boys with Attention Deficit/Hyperactivity DisorderNeuropsychopharmacology, 14
-
A. Barr, V. Lehmann-Masten, M. Paulus, R. Gainetdinov, M. Caron, M. Geyer (2004)
The Selective Serotonin-2A Receptor Antagonist M100907 Reverses Behavioral Deficits in Dopamine Transporter Knockout MiceNeuropsychopharmacology, 29
-
San-duo Jiang, R. Xin, Sicui Lin, Y. Qian, G. Tang, Dongxiang Wang, Xiaodong Wu, Xiaodong Wu (2001)
Linkage studies between attention-deficit hyperactivity disorder and the monoamine oxidase genes.American journal of medical genetics, 105 8
-
E. Coccaro, R. Kavoussi, Y. Sheline, M. Berman, J. Csernansky (1997)
Impulsive Aggression in Personality Disorder Correlates with Platelet 5-HT2A Receptor BindingNeuropsychopharmacology, 16
-
D. Comings, R. Gade‐Andavolu, N. Gonzalez, Shijuan Wu, D. Muhleman, H. Blake, F. Chiu, E. Wang, K. Farwell, S. Darakjy, R. Baker, G. Dietz, G. Saucier, J. Macmurray (2000)
Multivariate analysis of associations of 42 genes in ADHD, ODD and conduct disorderClinical Genetics, 58
-
R. Oades (2006)
Function and dysfunction of monoamine interactions in children and adolescents with AD/HD.EXS, 98
-
Jun Li, Chuanyuan Kang, Yufeng Wang, R. Zhou, B. Wang, L. Guan, Li Yang, S. Faraone (2006)
Contribution of 5‐HT2A receptor gene ‐1438A>G polymorphism to outcome of attention‐deficit/hyperactivity disorder in adolescentsAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 141B
-
L. Kent, U. Doerry, E. Hardy, R. Parmar, K. Gingell, Z. Hawi, A. Kirley, N. Lowe, Michael Fitzgerald, Michael Gill, N. Craddock (2002)
Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): analysis and pooled analysisMolecular Psychiatry, 7
-
B. Jacobs, C. Fornal, L. Wilkinson (1990)
Neurophysiological and Neurochemical Studies of Brain Serotonergic Neurons in Behaving Animals aAnnals of the New York Academy of Sciences, 600
-
J. Gallinat, D. Senkowski, C. Wernicke, G. Juckel, I. Becker, T. Sander, M. Smolka, U. Hegerl, H. Rommelspacher, G. Winterer, W. Herrmann (2003)
Allelic Variants of the Functional Promoter Polymorphism of the Human Serotonin Transporter Gene is Associated with Auditory Cortical Stimulus ProcessingNeuropsychopharmacology, 28
-
I. Antrop, Pieter Stock, Sylvie Verté, J. Wiersema, D. Baeyens, H. Roeyers (2006)
ADHD and delay aversion: the influence of non-temporal stimulation on choice for delayed rewards.Journal of child psychology and psychiatry, and allied disciplines, 47 11
-
J. Smoller, J. Biederman, L. Arbeitman, A. Doyle, J. Fagerness, R. Perlis, P. Sklar, S. Faraone (2006)
Association Between the 5HT1B Receptor Gene (HTR1B) and the Inattentive Subtype of ADHDBiological Psychiatry, 59
-
G. Hajcak, R. Simons (2002)
Error-related brain activity in obsessive–compulsive undergraduatesPsychiatry Research, 110
-
Y. Sari (2004)
Serotonin1B receptors: from protein to physiological function and behaviorNeuroscience & Biobehavioral Reviews, 28
-
S. Cheetham, J. Viggers, N. Slater, D. Heal, W. Buckett (1993)
[3H]Paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: Effect of administration of various antidepressant treatmentsNeuropharmacology, 32
-
J. Evenden (1999)
Varieties of impulsivityPsychopharmacology, 146
-
K. Rubia, E. Taylor, Anna Smith, H. Oksannen, S. Overmeyer, S. Newman (2001)
Neuropsychological analyses of impulsiveness in childhood hyperactivityBritish Journal of Psychiatry, 179
-
(1995)
Chronic MAO-B inhibition does not affect behavior in an animal model of attention deficit disorder -
S. Kähkönen, V. Mäkinen, I. Jääskeläinen, S. Pennanen, J. Liesivuori, J. Ahveninen (2005)
Serotonergic modulation of mismatch negativityPsychiatry Research: Neuroimaging, 138
-
U. Hegerl, R. Bottlender, J. Gallinat, H. Kuss, M. Ackenheil, H. Möller (1998)
The serotonin syndrome scale: first results on validityEuropean Archives of Psychiatry and Clinical Neuroscience, 248
-
Xiaohui Xu, K. Brookes, Chih-Ken Chen, Yu-Shu Huang, Yu-Yu Wu, P. Asherson (2007)
Association study between the monoamine oxidase A gene and attention deficit hyperactivity disorder in Taiwanese samplesBMC Psychiatry, 7
-
Savita Malhotra, P. Santosh (1998)
An open clinical trial of buspirone in children with attention-deficit/hyperactivity disorder.Journal of the American Academy of Child and Adolescent Psychiatry, 37 4
-
P. Heiser, A. Dempfle, S. Friedel, K. Konrad, A. Hinney, H. Kiefl, S. Walitza, T. Bettecken, K. Saar, M. Linder, A. Warnke, B. Herpertz-Dahlmann, H. Schäfer, H. Remschmidt, J. Hebebrand (2006)
Family-based association study of serotonergic candidate genes and attention-deficit/hyperactivity disorder in a German sampleJournal of Neural Transmission, 114
-
R.Adrian Clarke, D. Murphy, J. Constantino (1999)
Serotonin and externalizing behavior in young childrenPsychiatry Research, 86
-
K. Gadow (1992)
Pediatric psychopharmacotherapy: a review of recent research.Journal of child psychology and psychiatry, and allied disciplines, 33 1
-
P. Nathan, B. O’Neill, R. Croft (2005)
Is the Loudness Dependence of the Auditory Evoked Potential a Sensitive and Selective In Vivo Marker of Central Serotonergic Function?Neuropsychopharmacology, 30
-
R. Parsey, M. Oquendo, N. Simpson, R. Ogden, R. Heertum, V. Arango, J. Mann (2002)
Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635Brain Research, 954
-
J. Soghomonian, L. Descarries, K. Watkins (1989)
Serotonin innervation in adult rat neostriatum. II. Ultrastructural features: a radioautographic and immunocytochemical studyBrain Research, 481
-
A. Treisman (1969)
Strategies and models of selective attention.Psychological review, 76 3
-
Joseph Sergeant, Jaap Meere (1990)
CONVERGENCE OF APPROACHES IN LOCALIZING THE HYPERACTIVITY DEFICITAdvances in clinical child psychology, 13
-
J. Steiner, H. Bernstein, H. Bielau, Annika Berndt, R. Brisch, C. Mawrin, G. Keilhoff, B. Bogerts (2007)
Evidence for a wide extra-astrocytic distribution of S100B in human brainBMC Neuroscience, 8
-
R. Gade, D. Muhleman, H. Blake, J. Macmurray, P. Johnson, R. Verde, G. Saucier, D. Comings (1998)
Correlation of length of VNTR alleles at the X-linked MAOA gene and phenotypic effect in Tourette syndrome and drug abuseMolecular Psychiatry, 3
-
A. Zametkin, J. Rapoport (1987)
Neurobiology of attention deficit disorder with hyperactivity: where have we come in 50 years?Journal of the American Academy of Child and Adolescent Psychiatry, 26 5
-
K. Sheehan, Z. Hawi, M. Gill, L. Kent (2007)
No association between TPH2 gene polymorphisms and ADHD in a UK sampleNeuroscience Letters, 412
-
F. Castellanos, J. Elia, M. Kruesi, C. Gulotta, I. Mefford, William Potte, G. Ritchie, J. Rapoport (1994)
Cerebrospinal fluid monoamine metabolites in boys with attention-deficit hyperactivity disorderPsychiatry Research, 52
-
Warren Hirst, Nathan Cheung, Marcus Rattray, Gary Price, Graham Wilkin (1998)
Cultured astrocytes express messenger RNA for multiple serotonin receptor subtypes, without functional coupling of 5-HT1 receptor subtypes to adenylyl cyclase.Brain research. Molecular brain research, 61 1-2
-
R. Oades, Michael Slusarek, Silke Veiling, B. Bondy (2002)
Serotonin Platelet-Transporter Measures in Childhood Attention-Deficit/Hyperactivity Disorder (ADHD): Clinical versus Experimental Measures of ImpulsivityThe World Journal of Biological Psychiatry, 3
-
Ana Guimarães, C. Zeni, G. Polanczyk, J. Genro, T. Román, L. Rohde, M. Hutz (2007)
Serotonin genes and attention deficit/hyperactivity disorder in a Brazilian sample: Preferential transmission of the HTR2A 452His allele to affected boysAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 144B
-
S. Johnstone, Robert Barry, John Anderson (2001)
Topographic distribution and developmental timecourse of auditory event-related potentials in two subtypes of attention-deficit hyperactivity disorder.International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 42 1
-
R. Shiffrin, W. Schneider (1977)
Controlled and automatic human information processing: II. Perceptual learning, automatic attending and a general theory.Psychological Review, 84
-
E. Bekker, C. Overtoom, C. Overtoom, J. Kooij, J. Buitelaar, M. Verbaten, J. Kenemans (2005)
Disentangling deficits in adults with attention-deficit/hyperactivity disorder.Archives of general psychiatry, 62 10
-
Patricia Pailing, S. Segalowitz, J. Dywan, P. Davies (2002)
Error negativity and response control.Psychophysiology, 39 2
-
Attention Deficit Hyperactivity Disorder: Fine Mapping Supports Linkage to 5p13, 6q12, 16p13, and 17p11 -
S. Manuck, J. Flory, R. Ferrell, J. Mann, M. Muldoon (2000)
A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivityPsychiatry Research, 95
-
Anna Smith, E. Taylor, M. Brammer, K. Rubia (2004)
Neural correlates of switching set as measured in fast, event‐related functional magnetic resonance imagingHuman Brain Mapping, 21
-
J. Higley, William Thompson, M. Champoux, David Goldman, Mariken Hasert, Gary Kraemer, James Scanlan, S. Suomi, Markku Linnoila (1993)
Paternal and maternal genetic and environmental contributions to cerebrospinal fluid monoamine metabolites in rhesus monkeys (Macaca mulatta).Archives of general psychiatry, 50 8
-
• Good summary of the tasks used and the neuroimaging results obtained for the bases of impulsivity in childhood ADHD -
T. Kalenscher, T. Ohmann, O. Güntürkün (2006)
The neuroscience of impulsive and self-controlled decisions.International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 62 2
-
Michael Stanley, L. Traskman-Bendz, Katrina Dorovini-Zis (1985)
Correlations between aminergic metabolites simultaneously obtained from human CSF and brain.Life sciences, 37 14
-
J. Nigg (2005)
Neuropsychologic Theory and Findings in Attention-Deficit/Hyperactivity Disorder: The State of the Field and Salient Challenges for the Coming DecadeBiological Psychiatry, 57
-
Olivier Berton, S. Aguerre, Alain Sarrieau, Pierre Mormède, Francis Chaouloff (1997)
Differential effects of social stress on central serotonergic activity and emotional reactivity in Lewis and spontaneously hypertensive ratsNeuroscience, 82
-
Saul Rc, Ashby Cd (1986)
Measurement of whole blood serotonin as a guide in prescribing psychostimulant medication for children with attentional deficits.Clinical Neuropharmacology, 9
-
M. Virkkunen, D. Goldman, D. Nielsen, M. Linnoila (1995)
Low brain serotonin turnover rate (low CSF 5-HIAA) and impulsive violence.Journal of psychiatry & neuroscience : JPN, 20 4
-
S. Zoroglu, M. Erdal, B. Alaşehirli, N. Erdal, E. Si̇vasli, H. Tutkun, H. Savaş, H. Herken (2002)
Significance of Serotonin Transporter Gene 5-HTTLPR and Variable Number of Tandem Repeat Polymorphism in Attention Deficit Hyperactivity DisorderNeuropsychobiology, 45
-
A. Caspi, J. McClay, T. Moffitt, J. Mill, Judy Martin, I. Craig, Alan Taylor, R. Poulton (2002)
Role of Genotype in the Cycle of Violence in Maltreated ChildrenScience, 297
-
D. Lawson, D. Turic, K. Langley, H. Pay, C. Govan, N. Norton, M. Hamshere, M. Owen, M. O’Donovan, A. Thapar (2003)
Association analysis of monoamine oxidase A and attention deficit hyperactivity disorderAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 116B
-
M. Coleman (1971)
Serotonin concentrations in whole blood of hyperactive children.The Journal of pediatrics, 78 6
-
J. Daruna, P. Barnes (1993)
A neurodevelopmental view of impulsivity. -
O. Stiedl, I. Misane, M. Koch, T. Pattij, M. Meyer, S. Ögren (2007)
Activation of the brain 5-HT2C receptors causes hypolocomotion without anxiogenic-like cardiovascular adjustments in miceNeuropharmacology, 52
-
Anna Smith, E. Taylor, M. Brammer, B. Toone, K. Rubia (2006)
Task-specific hypoactivation in prefrontal and temporoparietal brain regions during motor inhibition and task switching in medication-naive children and adolescents with attention deficit hyperactivity disorder.The American journal of psychiatry, 163 6
-
E. Galili-Weisstub, R. Segman (2003)
Attention deficit and hyperactivity disorder: review of genetic association studies.The Israel journal of psychiatry and related sciences, 40 1
-
M. Posner, S. Petersen (1990)
The attention system of the human brain.Annual review of neuroscience, 13
-
B. Kosofsky, M. Molliver (1987)
The serotoninergic innervation of cerebral cortex: Different classes of axon terminals arise from dorsal and median raphe nucleiSynapse, 1
-
Jun Li, Yufeng Wang, R. Zhou, Hao-bo Zhang, Li Yang, B. Wang, S. Khan, S. Faraone (2005)
Serotonin 5‐HT1B receptor gene and attention deficit hyperactivity disorder in Chinese Han subjectsAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 132B
-
A. Thapar, K. Langley, P. Asherson, M. Gill (2007)
Gene ^ environment interplay in attention-deficit Gene ^ environment interplay in attention-deficit hyperactivity disorder and the importance hyperactivity disorder and the importance of a developmental perspective of a developmental perspective -
Z. Hughes, K. Starr, C. Scott, M. Newson, T. Sharp, J. Watson, J. Hagan, L. Dawson (2007)
Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-BPsychopharmacology, 192
-
C. Winstanley, J. Dalley, D. Theobald, T. Robbins (2004)
Fractionating Impulsivity: Contrasting Effects of Central 5-HT Depletion on Different Measures of Impulsive BehaviorNeuropsychopharmacology, 29
-
K. Tsukamoto, A. Sved, S. Ito, K. Komatsu, K. Kanmatsuse (2000)
Enhanced serotonin-mediated responses in the nucleus tractus solitarius of spontaneously hypertensive ratsBrain Research, 863
-
H. Steinbusch (1981)
Distribution of serotonin-immunoreactivity in the central nervous system of the rat—Cell bodies and terminalsNeuroscience, 6
-
American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 134B:67–72 (2005) Support for Association Between ADHD and Two Candidate Genes: NET1 and DRD1 -
S. Goozen, W. Matthys, P. Cohen-Kettenis, H. Westenberg, H. Engeland (1999)
Plasma monoamine metabolites and aggression: two studies of normal and oppositional defiant disorder childrenEuropean Neuropsychopharmacology, 9
-
A. Kusaga, Y. Yamashita, Tastuya Koeda, M. Hiratani, M. Kaneko, S. Yamada, T. Matsuishi (2002)
Increased urine phenylethylamine after methylphenidate treatment in children with ADHDAnnals of Neurology, 52
-
S. Dulawa, R. Hen, K. Scearce-Levie, M. Geyer (1997)
Serotonin1B receptor modulation of startle reactivity, habituation, and prepulse inhibition in wild-type and serotonin1B knockout micePsychopharmacology, 132
-
P. Jensen, L. Arnold, J. Severe, B. Vitiello, K. Hoagwood, S. Hinshaw, G. Elliott, C. Conners, K. Wells, J. March, J. Swanson, D. Cantwell, T. Wigal, H. Abikoff, J. Hechtman, Ll Greeenhill, J. Newcorn, W. Pelham, B. Hoza, H. Kraemer, R. Gibbons, E. Schiller (2004)
National Institute of Mental Health Multimodal Treatment Study of ADHD follow-up: 24-month outcomes of treatment strategies for attention-deficit/hyperactivity disorder.Pediatrics, 113 4
-
M. Ichise, D. Vines, Tami Gura, G. Anderson, S. Suomi, J. Higley, R. Innis (2006)
Effects of Early Life Stress on [11C]DASB Positron Emission Tomography Imaging of Serotonin Transporters in Adolescent Peer- and Mother-Reared Rhesus MonkeysThe Journal of Neuroscience, 26
-
Fabrice Pollier, S. Sarre, S. Aguerre, G. Ebinger, P. Mormède, Y. Michotte, F. Chaouloff (2000)
Serotonin Reuptake Inhibition by Citalopram in Rat Strains Differing for Their EmotionalityNeuropsychopharmacology, 22
-
T. Dierks, Stefan Barta, L. Demisch, K. Schmeck, E. Englert, Andrea Kewitz, K. Maurer, F. Poustka (1999)
Intensity dependence of auditory evoked potentials (AEPs) as biological marker for cerebral serotonin levels: effects of tryptophan depletion in healthy subjectsPsychopharmacology, 146
-
R. Oades, H. Christiansen (2008)
Cognitive switching processes in young people with attention-deficit/hyperactivity disorder.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 23 1
-
A. Meyer-Lindenberg, J. Buckholtz, B. Kolachana, Ahmad Hariri, L. Pezawas, G. Blasi, A. Wabnitz, R. Honea, B. Verchinski, J. Callicott, M. Egan, V. Mattay, D. Weinberger (2006)
Neural mechanisms of genetic risk for impulsivity and violence in humans.Proceedings of the National Academy of Sciences of the United States of America, 103 16
-
R. Oades (2002)
Dopamine may be ‘hyper’ with respect to noradrenaline metabolism, but ‘hypo’ with respect to serotonin metabolism in children with attention-deficit hyperactivity disorderBehavioural Brain Research, 130
-
(1998)
Challenging the anterior attentional system with a continuous performance task: a functional magnetic resonance imaging approachEuropean Archives of Psychiatry and Clinical Neuroscience, 248
-
R. Oades, R. Daniels, W. Rascher (1998)
Plasma neuropeptide-Y levels, monoamine metabolism, electrolyte excretion and drinking behavior in children with attention-deficit hyperactivity disorderPsychiatry Research, 80
-
T. Canli, Kazufumi Omura, Brian Haas, A. Fallgatter, R. Constable, K. Lesch (2005)
Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task.Proceedings of the National Academy of Sciences of the United States of America, 102 34
-
Extensive review of the interactions of the monoamines emphasizing the neurobiological bases at the synapse, the networks involved and their relevance to dysfunction in ADHD -
J. Quist, C. Barr, R. Schachar, W. Roberts, M. Malone, R. Tannock, V. Basile, J. Beitchman, J. Kennedy (2000)
Evidence for the serotonin HTR2A receptor gene as a susceptibility factor in attention deficit hyperactivity disorder (ADHD)Molecular Psychiatry, 5
-
Jean-Christophe Gauffre, S. Aguerre, P. Mormède, F. Chaouloff (1997)
Cortical [3H]ketanserin binding and 5-HT2A receptor-mediated inositol phosphate production in the spontaneously hypertensive rat and Lewis rat strainsNeuroscience Letters, 236
-
Iris Manor, J. Eisenberg, Samuel Tyano, Yonathan Sever, Hagit Cohen, R. Ebstein, R. Ebstein, Moshe Kotler (2001)
Family-based association study of the serotonin transporter promoter region polymorphism (5-HTTLPR) in attention deficit hyperactivity disorder.American journal of medical genetics, 105 1
-
B. Jemel, C. Achenbach, B. Müller, B. Röpcke, R. Oades (2004)
Mismatch Negativity Results from Bilateral Asymmetric Dipole Sources in the Frontal and Temporal LobesBrain Topography, 15
-
K. Brookes, Xiaohui Xu, Wai Chen, K. Zhou, B. Neale, N. Lowe, R. Aneey, Barbara Franke, M. Gill, J. Buitelaar, Pak Sham, Desmond Campbell, Joanne Knight, P. Andreou, M. Altink, R. Arnold, Frits Boer, C. Buschgens, L. Butler, Hanna Christiansen, Liat Feldman, K. Fleischman, E. Fliers, R. Howe-Forbes, Abigail Goldfarb, A. Heise, I. Gabriëls, Isabelle Korn-Lubetzki, R. Marco, S. Medad, R. Minderaa, F. Mulas, U. Müller, A. Mulligan, Karina Rabin, Nanda Rommelse, V. Sethna, Jean Sorohan, H. Uebel, L. Psychogiou, A. Weeks, R. Barrett, I. Craig, T. Banaschewski, E. Sonuga-Barke, J. Eisenberg, J. Kuntsi, I. Manor, P. McGuffin, A. Miranda, R. Oades, R. Plomin, Herbert Roeyers, A. Rothenberger, J. Sergeant, H. Steinhausen, E. Taylor, M. Thompson, S. Faraone, P. Asherson, L. Johansson (2006)
The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genesMolecular Psychiatry, 11
-
Wide-ranging account across the animal kingdom of the anatomical and neurotransmitters bases of impulsivity, with special reference to temporal discounting/delayed gratification -
S. Macrì, S. Spinelli, W. Adriani, J. Higley, G. Laviola (2007)
Early adversity and alcohol availability persistently modify serotonin and hypothalamic–pituitary–adrenal-axis metabolism and related behavior: What experimental research on rodents and primates can tell usNeuroscience & Biobehavioral Reviews, 31
-
L. Passamonti, F. Fera, A. Magariello, A. Cerasa, M. Gioia, M. Muglia, G. Nicoletti, O. Gallo, L. Provinciali, A. Quattrone (2006)
Monoamine Oxidase-A Genetic Variations Influence Brain Activity Associated with Inhibitory Control: New Insight into the Neural Correlates of ImpulsivityBiological Psychiatry, 59
-
B. Spivak, Y. Vered, R. Yoran-Hegesh, E. Averbuch, R. Mester, E. Graf, Abraham Weizman (1999)
Circulatory levels of catecholamines, serotonin and lipids in attention deficit hyperactivity diiorderActa Psychiatrica Scandinavica, 99
-
Jan Wiersema, J. Meere, H. Roeyers (2005)
ERP correlates of impaired error monitoring in children with ADHDJournal of Neural Transmission, 112
-
Jun Li, Yufeng Wang, R. Zhou, B. Wang, Hao-bo Zhang, Li Yang, S. Faraone (2006)
No association of attention-deficit/hyperactivity disorder with genes of the serotonergic pathway in Han Chinese subjectsNeuroscience Letters, 403
-
C. Escera, M. Corral, Elena Yago (2002)
An electrophysiological and behavioral investigation of involuntary attention towards auditory frequency, duration and intensity changes.Brain research. Cognitive brain research, 14 3
-
R. Oades, B. Müller (1997)
The development of conditioned blocking and monoamine metabolism in children with attention-deficit-hyperactivity disorder or complex tics and healthy controls: an exploratory analysisBehavioural Brain Research, 88
-
C. Overtoom, M. Verbaten, C. Kemner, J. Kenemans, H. Engeland, J. Buitelaar, M. Molen, J. Gugten, H. Westenberg, R. Maes, H. Koelega (2003)
Effects of methylphenidate, desipramine, and l-dopa on attention and inhibition in children with Attention Deficit Hyperactivity DisorderBehavioural Brain Research, 145
-
G. Lucas, V. Compan, Y. Charnay, R. Neve, E. Nestler, J. Bockaert, M. Barrot, G. Debonnel (2005)
Frontocortical 5-HT4 receptors exert positive feedback on serotonergic activity: Viral transfections, subacute and chronic treatments with 5-HT4 agonistsBiological Psychiatry, 57
-
(2006)
Functional neuroimaging of rapid tryptophan depletion -
I. Manor, S. Tyano, E. Mel, J. Eisenberg, R. Bachner-Melman, M. Kotler, R. Ebstein (2002)
Family-based and association studies of monoamine oxidase A and attention deficit hyperactivity disorder (ADHD): preferential transmission of the long promoter-region repeat and its association with impaired performance on a continuous performance test (TOVA)Molecular Psychiatry, 7
-
Disabilities (1996)
Medication for Children With Attentional DisordersPediatrics
-
S. Eastwood, P. Burnet, R. Gittins, K. Baker, Paul Harrison (2001)
Expression of serotonin 5‐HT2A receptors in the human cerebellum and alterations in schizophreniaSynapse, 42
-
I. Törk (1990)
Anatomy of the Serotonergic System aAnnals of the New York Academy of Sciences, 600
-
F. Lung, Pinchen Yang, T. Cheng, Wei-Tsung Kao (2007)
No Allele Variation of the MAOA Gene Promoter in Male Chinese Subjects with Attention Deficit Hyperactivity DisorderNeuropsychobiology, 54
-
M. Bubar, K. Cunningham (2007)
Distribution of serotonin 5-HT2C receptors in the ventral tegmental areaNeuroscience, 146
-
M. Das, A. Bhowmik, S. Sinha, A. Chattopadhyay, K. Chaudhuri, Manoranjan Singh, K. Mukhopadhyay (2006)
MAOA promoter polymorphism and attention deficit hyperactivity disorder (ADHD) in indian childrenAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 141B
-
G. Seeger, Patrick Schloss, Martin Schmidt (2001)
Marker gene polymorphisms in hyperkinetic disorder – predictors of clinical response to treatment with methylphenidate?Neuroscience Letters, 313
-
T. Slotkin, Ian Ryde, C. Tate, F. Seidler (2007)
Lasting effects of nicotine treatment and withdrawal on serotonergic systems and cell signaling in rat brain regions: Separate or sequential exposure during fetal development and adulthoodBrain Research Bulletin, 73
-
A. Pfefferbaum, W. Roth, J. Ford (1995)
Event-related potentials in the study of psychiatric disorders.Archives of general psychiatry, 52 7
-
I. Uhl, I. Gorynia, J. Gallinat, C. Mulert, A. Wutzler, A. Heinz, G. Juckel (2006)
Is the loudness dependence of auditory evoked potentials modulated by the selective serotonin reuptake inhibitor citalopram in healthy subjects?Human Psychopharmacology: Clinical and Experimental, 21
-
P. Asherson (2005)
Clinical assessment and treatment of attention deficit hyperactivity disorder in adultsExpert Review of Neurotherapeutics, 5
-
K. Rubia, Anna Smith, M. Brammer, B. Toone, E. Taylor (2005)
Abnormal brain activation during inhibition and error detection in medication-naive adolescents with ADHD.The American journal of psychiatry, 162 6
-
T. Shetty, T. Chase (1976)
Central monoamines and hyperkinesis of childhoodNeurology, 26
-
M. Durand, Olivier Berton, S. Aguerre, L. Edno, I. Combourieu, Pierre Mormède, Francis Chaouloff (1999)
Effects of repeated fluoxetine on anxiety-related behaviours, central serotonergic systems, and the corticotropic axis in SHR and WKY ratsNeuropharmacology, 38
-
H. Ferguson, B. Pappas, R. Trites, D. Peters, H. Taub (1981)
Plasma free and total tryptophan, blood serotonin, and the hyperactivity syndrome: no evidence for the serotonin deficiency hypothesis.Biological psychiatry, 16 3
-
M. Reuter, P. Kirsch, J. Hennig (2006)
Inferring candidate genes for Attention Deficit Hyperactivity Disorder (ADHD) assessed by the World Health Organization Adult ADHD Self-Report Scale (ASRS)Journal of Neural Transmission, 113
-
D. Schalling, M. Åsberg, G. Edman, L. Oreland (1987)
Markers for vulnerability to psychopathology: Temperament traits associated with platelet MAO activityActa Psychiatrica Scandinavica, 76
-
K. Wigg, A. Takhar, A. Ickowicz, R. Tannock, J. Kennedy, Tejaswee Pathare, M. Malone, R. Schachar, C. Barr (2006)
Gene for the serotonin transporter and ADHD: No association with two functional polymorphismsAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 141B
-
U. Hegerl, G. Juckel (1993)
Intensity dependence of auditory evoked potentials as an indicator of central serotonergic neurotransmission: A new hypothesisBiological Psychiatry, 33
-
Katherine Alex, Gregory Yavanian, H. McFarlane, C. Pluto, E. Pehek (2005)
Modulation of dopamine release by striatal 5‐HT2C receptorsSynapse, 55
-
C. Stadler, K. Schmeck, I. Nowraty, W. Müller, F. Poustka (2004)
Platelet 5-HT Uptake in Boys with Conduct DisorderNeuropsychobiology, 50
-
P. Barone, Daniel Jordan, F. Atger, N. Kopp, G. Fillion (1994)
Quantitative autoradiography of 5-HT1D and 5-HT1E binding sites labelled by [3H]5-HT, in frontal cortex and the hippocampal region of the human brainBrain Research, 638
-
M. Liotti, S. Pliszka, R. Pérez, Delia Kothmann, M. Woldorff (2005)
Abnormal Brain Activity Related to Performance Monitoring and Error Detection in Children with ADHDCortex, 41
- Publisher
- Taylor & Francis
- Copyright
- © Future Drugs Ltd
- ISSN
- 1744-8360
- eISSN
- 1473-7175
- DOI
- 10.1586/14737175.7.10.1357
- pmid
- 17939772
- Publisher site
- See Article on Publisher Site
Abstract
A limited number of studies have considered whether the activity of serotonin (5-hydroxytryptamine [5-HT]) contributes to the problems experienced by youngsters with attention-deficit/hyperactivity disorder (ADHD). The aim of this article is to review this work and propose interpretations. Peripheral measures of 5-HT and its metabolite do not point to a widespread association with the diagnosis. However, separate consideration of the major domains of dysfunction (motor activity, inattention and impulsivity) support a more differentiated assessment. The marked innervation of motor regions of the brain by 5-HT projections and the clear involvement of 5-HT systems in the control of locomotion in animals suggests a likely node for dysfunction in ADHD. The few relevant studies do not show evidence of this, but more attention should be accorded to the issue. The situation is different for attention-related processes; here, there are deficiencies in perceptual sensitivity and the appropriate designation of saliency to stimulation. These are attributable, in part, to altered 5-HT activity. Marked and opposite changes of 5-HT responsivity are associated with behavioral and cognitive impulsivity. There is also a growing series of studies demonstrating preferential transmission of various genetic markers for 5-HT receptors that are expressed in ADHD. Currently, the heterogeneity of methods in this young discipline restricts the possibilities of definition of these markers and the types of ADHD in which they are expressed.
Journal
Expert Review of Neurotherapeutics – Taylor & Francis
Published: Oct 1, 2007
Keywords: attention; attention-deficit/hyperactivity disorder; genetics; glia; impulsivity; motor; neurotrophin; serotonin