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- Publisher
- Oxford University Press
- Copyright
- © 1990 The British Society for Antimicrobial Chemotherapy
- ISSN
- 0305-7453
- eISSN
- 1460-2091
- DOI
- 10.1093/jac/25.2.269
- Publisher site
- See Article on Publisher Site
Abstract
Abstract The pharmacokinetics of amoxycillin and potassium clavulanate were studied in 15 sick children after a 30 min iv infusion of 50 mg/kg amoxycillin and 5 mg/kg clavulanic acid as the potassium salt. Levels of both compounds in plasma were assayed mkrobiologically. Mean peak concentrations at the end of the infusion were 121·0 mg/l of amoxycillin and 12·0 mg/l of clavulanate, falling to a mean of 15·8 and 1·92 mg/l respectively after 2h. Mean (β phase T½ was 0·88 h for amoxycillin and 0·79 h for clavulanate. The elimination half-life of clavulanate in some individuals was much shorter because of higher plasma clearance. The data suggest that the treatment of some infections due to β-lactamase producing organisms in such severely ill children may require more frequent iv administration of amoxycillin and potassium clavulanate, than in less severely affected children. This content is only available as a PDF. © 1990 The British Society for Antimicrobial Chemotherapy
Journal
Journal of Antimicrobial Chemotherapy – Oxford University Press
Published: Feb 1, 1990