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Oral Microbiome: A New Biomarker Reservoir for Oral and Oropharyngeal Cancers

Oral Microbiome: A New Biomarker Reservoir for Oral and Oropharyngeal Cancers Current biomarkers (DNA, RNA and protein) for oral cavity and oropharyngeal cancers demonstrate biological variations between individuals, rendering them impractical for clinical translation. Whilst these biomarkers originate from the host, there is not much information in the literature about the influence of oral microbiota on cancer pathogenesis, especially in oral cancers. Oral microbiotas are known to participate in disease initiation and progression not only limited to the oral cavity, but also at other distant sites. Due to the close proximity of oral microbiota and oral cavity and oropharyngeal tumours, abundance changes in oral microbiota may provide useful information on tumourigenesis. This review aims to highlight information on the role of oral microbiota in oral cavity and oropharyngeal cancers. An in-depth analysis into the oral microbiota may provide a new avenue to diagnose and treat these patients. Key words: biomarker, oral and oropharyngeal cancers, oral microbiome. Oral Microbiome Oral microbiome, by definition, is the collective preferred pH for most bacteria species [5, 6]. Saliva genomes of microorganisms that reside in the oral also keeps bacteria hydrated and acts as a medium to cavity [1-3]. Many researchers believe that the facilitate the transportation of nutrients to characterisation of oral microbiome is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Theranostics Unpaywall

Oral Microbiome: A New Biomarker Reservoir for Oral and Oropharyngeal Cancers

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References (70)

Publisher
Unpaywall
ISSN
1838-7640
DOI
10.7150/thno.21804
Publisher site
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Abstract

Current biomarkers (DNA, RNA and protein) for oral cavity and oropharyngeal cancers demonstrate biological variations between individuals, rendering them impractical for clinical translation. Whilst these biomarkers originate from the host, there is not much information in the literature about the influence of oral microbiota on cancer pathogenesis, especially in oral cancers. Oral microbiotas are known to participate in disease initiation and progression not only limited to the oral cavity, but also at other distant sites. Due to the close proximity of oral microbiota and oral cavity and oropharyngeal tumours, abundance changes in oral microbiota may provide useful information on tumourigenesis. This review aims to highlight information on the role of oral microbiota in oral cavity and oropharyngeal cancers. An in-depth analysis into the oral microbiota may provide a new avenue to diagnose and treat these patients. Key words: biomarker, oral and oropharyngeal cancers, oral microbiome. Oral Microbiome Oral microbiome, by definition, is the collective preferred pH for most bacteria species [5, 6]. Saliva genomes of microorganisms that reside in the oral also keeps bacteria hydrated and acts as a medium to cavity [1-3]. Many researchers believe that the facilitate the transportation of nutrients to characterisation of oral microbiome is

Journal

Theranostics – Unpaywall

Published: Jan 1, 2017

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