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Infection and Cancer: Bi-Directorial InteractionsBacterial Infections and Cancer Development

Infection and Cancer: Bi-Directorial Interactions: Bacterial Infections and Cancer Development [Multiple epidemiological and clinical studies have identified an association between specific bacterial infection and cancers. Several bacterial infections have been proven to serve as risk factors for the initial development and survival of cancerous cells in different tissues and organs. It is estimated that about 20–25 % of all human cancers are caused by chronic infection-derived inflammation. A sustained production of various reactive aldehydes, oxygen and nitrogen species, as well as cytokines, chemokines and growth factors, at the inflammatory microenvironment can perturb normal biological and physiological processes leading to genomic instability and an increased risk of cancer development. Furthermore, toxins produced by bacteria, different bacteria-derived metabolites and some bacterial virulence factors may be also involved in the associated tumorigenic processes via DNA damage response, cell cycle regulation and other mechanisms. Unfortunately, it is still not fully clear which combinations of specific bacteria-associated factors and microenvironmental stimuli contribute to high incidence of cancer during certain infectious diseases. Understanding the mechanisms of how bacterial infections affect cancer development and progression will promote new or more efficient approaches to cancer prevention and therapy.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Infection and Cancer: Bi-Directorial InteractionsBacterial Infections and Cancer Development

Editors: Shurin, Michael R.; Thanavala, Yasmin; Ismail, Nahed
Agassandian, Marianna; Shurin, Galina V.
Infection and Cancer: Bi-Directorial Interactions — Jun 13, 2015
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References (218)

Publisher
Springer International Publishing
Copyright
© Springer International Publishing Switzerland 2015
ISBN
978-3-319-20668-4
Pages
49–74
DOI
10.1007/978-3-319-20669-1_4
Publisher site
See Chapter on Publisher Site

Abstract

[Multiple epidemiological and clinical studies have identified an association between specific bacterial infection and cancers. Several bacterial infections have been proven to serve as risk factors for the initial development and survival of cancerous cells in different tissues and organs. It is estimated that about 20–25 % of all human cancers are caused by chronic infection-derived inflammation. A sustained production of various reactive aldehydes, oxygen and nitrogen species, as well as cytokines, chemokines and growth factors, at the inflammatory microenvironment can perturb normal biological and physiological processes leading to genomic instability and an increased risk of cancer development. Furthermore, toxins produced by bacteria, different bacteria-derived metabolites and some bacterial virulence factors may be also involved in the associated tumorigenic processes via DNA damage response, cell cycle regulation and other mechanisms. Unfortunately, it is still not fully clear which combinations of specific bacteria-associated factors and microenvironmental stimuli contribute to high incidence of cancer during certain infectious diseases. Understanding the mechanisms of how bacterial infections affect cancer development and progression will promote new or more efficient approaches to cancer prevention and therapy.]

Published: Jun 13, 2015

Keywords: Inflammation; Carcinogenesis; Bacterial toxins; DNA damage DNA damage; Infectious diseases

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