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- Publisher
- Taylor & Francis
- Copyright
- Copyright Taylor & Francis Group, LLC
- ISSN
- 1532-2432
- eISSN
- 0039-7911
- DOI
- 10.1080/00397911.2011.565142
- Publisher site
- See Article on Publisher Site
Abstract
Abstract Novel 4-alkoxy-dithionaphthoic acids were prepared and shown to be valuable synthons for δ-amino acid conjugates. These dithioacids are efficiently synthesized and purified, stable to storage, and easily derivatized to facilitate thioacylation chemistry. To this end, we have demonstrated dithionaphthoic acids (6) to successfully undergo coupling with both protected and unprotected amino acids, giving rise to stable thioamide conjugates (8 and 9).
Journal
Synthetic Communications – Taylor & Francis
Published: Sep 15, 2012
Keywords: Bioconjugates; dithioacid; naphthalene; thioacylation; thioamide coupling