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Primary structure, recombinant expression and homology modelling of human brain prolyl oligopeptidase, an important therapeutic target in the treatment of neuropsychiatric diseases

Primary structure, recombinant expression and homology modelling of human brain prolyl... ` Institut de Recerca Biomedica de Barcelona, Parc Cient´fic de Barcelona, E-08028 Barcelona, Spain ı ´ ´ ´ Departamento de Qu´mica Farmacologica y Toxicologica, Facultad de Ciencias Qu´micas y Farmaceuticas, Universidad de Chile, Santiago, ı ı Chile c Plataforma de Proteomica, Parc Cient´fic de Barcelona, Serveis Cient´fico-Tecnics, Universitat de Barcelona, E-08028 Barcelona, Spain ` ` ı ı d Departament de Qu´mica Organica Universitat de Barcelona, E-08028 Barcelona, Spain ` ı b a Received 21 February 2005; Accepted 3 March 2005 Keywords: bipolar affective disorder; neuropeptides; prolyl oligopeptidase; schizophrenia; structural homology model; proteomics INTRODUCTION There is no doubt that Murray Goodman can be considered as a pioneer in the conformational analysis of proline-rich polypeptides. His decorated career was marked by seminal contributions to the synthesis and conformational studies of poly(L-prolyl-Lα-phenylglycyl-L-proline) [1], followed by theoretical calculations of poly[(S)-thiazolidine-4-carboxylic acid] [2], a ‘thia-poly-L-proline’, and important work in the field of collagen mimetics [3]. During a sabbatical year (1990–1991) spent by one of these authors, (E.G.) in San Diego as both a research associate at the Scripps Research Institute, La Jolla, CA, and a visiting professor in Murray’s laboratory at the University of California, San Diego, he was able to appreciate first http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Peptide Science Wiley

Primary structure, recombinant expression and homology modelling of human brain prolyl oligopeptidase, an important therapeutic target in the treatment of neuropsychiatric diseases

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References (28)

Publisher
Wiley
Copyright
Copyright © 2005 Wiley Subscription Services
ISSN
1075-2617
eISSN
1099-1387
DOI
10.1002/psc.676
pmid
15838896
Publisher site
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Abstract

` Institut de Recerca Biomedica de Barcelona, Parc Cient´fic de Barcelona, E-08028 Barcelona, Spain ı ´ ´ ´ Departamento de Qu´mica Farmacologica y Toxicologica, Facultad de Ciencias Qu´micas y Farmaceuticas, Universidad de Chile, Santiago, ı ı Chile c Plataforma de Proteomica, Parc Cient´fic de Barcelona, Serveis Cient´fico-Tecnics, Universitat de Barcelona, E-08028 Barcelona, Spain ` ` ı ı d Departament de Qu´mica Organica Universitat de Barcelona, E-08028 Barcelona, Spain ` ı b a Received 21 February 2005; Accepted 3 March 2005 Keywords: bipolar affective disorder; neuropeptides; prolyl oligopeptidase; schizophrenia; structural homology model; proteomics INTRODUCTION There is no doubt that Murray Goodman can be considered as a pioneer in the conformational analysis of proline-rich polypeptides. His decorated career was marked by seminal contributions to the synthesis and conformational studies of poly(L-prolyl-Lα-phenylglycyl-L-proline) [1], followed by theoretical calculations of poly[(S)-thiazolidine-4-carboxylic acid] [2], a ‘thia-poly-L-proline’, and important work in the field of collagen mimetics [3]. During a sabbatical year (1990–1991) spent by one of these authors, (E.G.) in San Diego as both a research associate at the Scripps Research Institute, La Jolla, CA, and a visiting professor in Murray’s laboratory at the University of California, San Diego, he was able to appreciate first

Journal

Journal of Peptide Science – Wiley

Published: Jan 1, 2005

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