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The NET, the trap and the pathogen: neutrophil extracellular traps in cutaneous immunity

The NET, the trap and the pathogen: neutrophil extracellular traps in cutaneous immunity Neutrophil extracellular traps (NETs), large chromatin structures casted with various proteins, are externalized by neutrophils upon induction by both self‐ and non‐self‐stimuli. It has become clear that NETs are potent triggers of inflammation in autoimmune skin diseases. Moreover, the ability of NETs to trap pathogens suggests a crucial role in innate host defense. However, the outcome of the encounter between pathogens and NETs remains highly controversial. Here, we discuss recent insights into the morphology and formation of NETs, their role in skin inflammation and how NETs might contribute to host protection in skin infection. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experimental Dermatology Wiley

The NET, the trap and the pathogen: neutrophil extracellular traps in cutaneous immunity

Stephan, Alexander; Fabri, Mario
Experimental Dermatology , Volume 24 (3) – Mar 1, 2015
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References (152)

Publisher
Wiley
Copyright
"© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd"
ISSN
0906-6705
eISSN
1600-0625
DOI
10.1111/exd.12599
pmid
25421224
Publisher site
See Article on Publisher Site

Abstract

Neutrophil extracellular traps (NETs), large chromatin structures casted with various proteins, are externalized by neutrophils upon induction by both self‐ and non‐self‐stimuli. It has become clear that NETs are potent triggers of inflammation in autoimmune skin diseases. Moreover, the ability of NETs to trap pathogens suggests a crucial role in innate host defense. However, the outcome of the encounter between pathogens and NETs remains highly controversial. Here, we discuss recent insights into the morphology and formation of NETs, their role in skin inflammation and how NETs might contribute to host protection in skin infection.

Journal

Experimental Dermatology – Wiley

Published: Mar 1, 2015

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