Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/the-emt-activator-zeb1-promotes-tumorigenicity-by-repressing-stemness-HD0oTnOpJI
References (49)
-
S. Gou, Tao Liu, Chun-you Wang, T. Yin, Kai Li, Ming-tao Yang, Jing Zhou (2007)
Establishment of Clonal Colony-Forming Assay for Propagation of Pancreatic Cancer Cells With Stem Cell PropertiesPancreas, 34
-
F. Schreiber, T. Deramaudt, T. Brunner, M. Boretti, K. Gooch, D. Stoffers, E. Bernhard, A. Rustgi (2004)
Successful growth and characterization of mouse pancreatic ductal cells: functional properties of the Ki-RAS(G12V) oncogene.Gastroenterology, 127 1
-
T Brabletz (2004)
Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progressionCancer Res., 64
-
Sonia Vega, A. Morales, Oscar Ocaña, Francisco Valdés, I. Fabregat, M. Nieto (2004)
Snail blocks the cell cycle and confers resistance to cell death.Genes & development, 18 10
-
H. Peinado, David Olmeda, A. Cano (2007)
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?Nature Reviews Cancer, 7
-
In-kyung Park, D. Qian, M. Kiel, M. Becker, Michael Pihalja, I. Weissman, S. Morrison, M. Clarke (2003)
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cellsNature, 423
-
M. Bar, S. Wyman, B. Fritz, Junlin Qi, Kavita Garg, R. Parkin, E. Kroh, Ausra Bendoraite, P. Mitchell, Angelique Nelson, W. Ruzzo, C. Ware, J. Radich, R. Gentleman, H. Ruohola-Baker, M. Tewari (2008)
MicroRNA Discovery and Profiling in Human Embryonic Stem Cells by Deep Sequencing of Small RNA LibrariesSTEM CELLS, 26
-
Kazutoshi Takahashi, K. Tanabe, M. Ohnuki, Megumi Narita, T. Ichisaka, K. Tomoda, S. Yamanaka (2007)
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined FactorsCell, 131
-
A. Saeed, V. Sharov, J. White, J. Li, W. Liang, N. Bhagabati, J. Braisted, M. Kłapa, T. Currier, M. Thiagarajan, A. Sturn, M. Snuffin, A. Rezantsev, D. Popov, A. Ryltsov, E. Kostukovich, I. Borisovsky, Z. Liu, A. Vinsavich, V. Trush, John Quackenbush (2003)
TM4: a free, open-source system for microarray data management and analysis.BioTechniques, 34 2
-
C Li (2007)
Identification of pancreatic cancer stem cellsCancer Res., 67
-
J. Godlewski, M. Nowicki, A. Bronisz, Shante Williams, Akihiro Otsuki, G. Nuovo, A. Raychaudhury, H. Newton, E. Chiocca, S. Lawler (2008)
Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal.Cancer research, 68 22
-
A. Morel, M. Lièvre, Clémence Thomas, G. Hinkal, S. Ansieau, A. Puisieux (2008)
Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal TransitionPLoS ONE, 3
-
T. Brabletz, S. Spaderna, J. Kolb, F. Hlubek, G. Faller, C. Bruns, A. Jung, J. Nentwich, I. Duluc, C. Domon-Dell, T. Kirchner, J. Freund (2004)
Down-Regulation of the Homeodomain Factor Cdx2 in Colorectal Cancer by Collagen Type ICancer Research, 64
-
T. Brummelkamp, R. Bernards, R. Agami (2002)
A System for Stable Expression of Short Interfering RNAs in Mammalian CellsScience, 296
-
D. Darling, Randi Stearman, Ying-ying Qi, M. Qiu, Joseph Feller (2003)
Expression of Zfhep/deltaEF1 protein in palate, neural progenitors, and differentiated neurons.Gene expression patterns : GEP, 3 6
-
Qing-quan Li, Jing-da Xu, Wen-juan Wang, Xi-xi Cao, Qi Chen, F. Tang, Zhong-qing Chen, Xiu-Ping Liu, Zu-de Xu (2009)
Twist1-Mediated Adriamycin-Induced Epithelial-Mesenchymal Transition Relates to Multidrug Resistance and Invasive Potential in Breast Cancer CellsClinical Cancer Research, 15
-
Ami Shah, J. Summy, Jing Zhang, Serk Park, N. Parikh, G. Gallick (2007)
Development and Characterization of Gemcitabine-Resistant Pancreatic Tumor CellsAnnals of Surgical Oncology, 14
-
P. Dalerba, Robert Cho, M. Clarke (2007)
Cancer stem cells: models and concepts.Annual review of medicine, 58
-
G. Hurteau, J. Carlson, S. Spivack, G. Brock (2007)
Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin.Cancer research, 67 17
-
Carles Martínez-Romero, I. Rooman, A. Skoudy, C. Guerra, X. Molero, A. González, M. Iglesias, T. Lobato, Almudena Bosch, M. Barbacid, F. Real, I. Hernández-Muñoz (2009)
The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinomaThe Journal of Pathology, 219
-
M. Peter (2009)
Let-7 and miR-200 microRNAs: Guardians against pluripotency and cancer progressionCell Cycle, 8
-
S. Spaderna, O. Schmalhofer, F. Hlubek, G. Berx, A. Eger, S. Merkel, A. Jung, T. Kirchner, T. Brabletz (2006)
A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer.Gastroenterology, 131 3
-
V. Smith, G. Wirth, H. Fiebig, A. Burger (2008)
Tissue microarrays of human tumor xenografts: characterization of proteins involved in migration and angiogenesis for applications in the development of targeted anticancer agents.Cancer genomics & proteomics, 5 5
-
Alejandro Barrallo-Gimeno, M. Nieto (2005)
The Snail genes as inducers of cell movement and survival: implications in development and cancer, 132
-
G. Berx, E. Raspé, G. Christofori, J. Thiery, J. Sleeman (2007)
Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancerClinical & Experimental Metastasis, 24
-
U. Burk, Jörg Schubert, U. Wellner, O. Schmalhofer, E. Vincan, S. Spaderna, T. Brabletz (2008)
A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cellsEMBO Reports, 9
-
R. Shoemaker (2006)
The NCI60 human tumour cell line anticancer drug screenNature Reviews Cancer, 6
-
(2001)
Significance analysis of microarrays applied to the ionizing radiation response -
T. Brabletz, A. Jung, S. Spaderna, F. Hlubek, T. Kirchner (2005)
Migrating cancer stem cells — an integrated concept of malignant tumour progressionNature Reviews Cancer, 5
-
(2007)
an alliance against the epithelial phenotype? Nature Rev -
Sun-Mi Park, A. Gaur, E. Lengyel, M. Peter (2008)
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2.Genes & development, 22 7
-
R. Yi, Matthew Poy, M. Stoffel, E. Fuchs (2008)
A skin microRNA promotes differentiation by repressing ‘stemness’Nature, 452
-
J. Krützfeldt, S. Kuwajima, Ravi Braich, K. Rajeev, John Pena, T. Tuschl, M. Manoharan, M. Stoffel (2007)
Specificity, duplex degradation and subcellular localization of antagomirsNucleic Acids Research, 35
-
A. Esquela-Kerscher, F. Slack (2006)
Oncomirs — microRNAs with a role in cancerNature Reviews Cancer, 6
-
M. Korpal, Esther Lee, G. Hu, Yibin Kang (2008)
The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional Repressors ZEB1 and ZEB2*Journal of Biological Chemistry, 283
-
F. Hlubek, A. Jung, N. Kotzor, T. Kirchner, T. Brabletz (2001)
Expression of the Invasion Factor Laminin γ2 in Colorectal Carcinomas Is Regulated by β-CateninCancer Research, 61
-
TS Schreiber (2004)
Successful growth of mouse pancreatic ductal cells: functional properties of the ki-RAS (G12V) oncogeneGastroenterology, 127
-
N. Christoffersen, A. Silahtaroglu, U. Orom, S. Kauppinen, A. Lund (2007)
miR-200b mediates post-transcriptional repression of ZFHX1B.RNA, 13 8
-
I. Ben-Porath, Matthew Thomson, V. Carey, Ruping Ge, G. Bell, A. Regev, R. Weinberg (2008)
An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumorsNature Genetics, 40
-
S. Spaderna, O. Schmalhofer, M. Wahlbuhl, A. Dimmler, K. Bauer, Aneesa Sultan, F. Hlubek, A. Jung, D. Strand, A. Eger, T. Kirchner, J. Behrens, T. Brabletz (2008)
The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer.Cancer research, 68 2
-
J. Winter, A. Ting, F. Vilardell, E. Gallmeier, S. Baylin, R. Hruban, S. Kern, C. Iacobuzio-Donahue (2008)
Absence of E-Cadherin Expression Distinguishes Noncohesive from Cohesive Pancreatic CancerClinical Cancer Research, 14
-
Sendurai Mani, Wenjun Guo, Mai-Jing Liao, E. Eaton, Ayyakkannu Ayyanan, A. Zhou, M. Brooks, Ferenc Reinhard, C. Zhang, M. Shipitsin, Lauren Campbell, K. Polyak, C. Brisken, Jing Yang, R. Weinberg (2008)
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem CellsCell, 133
-
B. Hotz, M. Arndt, S. Dullat, Sarah Bhargava, H. Buhr, H. Hotz (2007)
Epithelial to Mesenchymal Transition: Expression of the Regulators Snail, Slug, and Twist in Pancreatic CancerClinical Cancer Research, 13
-
C. Belar (2005)
Models and Concepts -
S. Hingorani, Lifu Wang, A. Multani, C. Combs, T. Deramaudt, R. Hruban, A. Rustgi, Sandy Chang, D. Tuveson (2005)
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice.Cancer cell, 7 5
-
T. Brabletz, A. Jung, S. Reu, M. Porzner, F. Hlubek, L. Kunz-Schughart, R. Knuechel, T. Kirchner (2001)
Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environmentProceedings of the National Academy of Sciences of the United States of America, 98
-
P. Gregory, A. Bert, Emily Paterson, S. Barry, A. Tsykin, G. Farshid, M. Vadas, Y. Khew-Goodall, G. Goodall (2008)
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1Nature Cell Biology, 10
-
Y. Shimono, M. Zabala, Robert Cho, N. Lobo, P. Dalerba, D. Qian, M. Diehn, Huiping Liu, S. Panula, E. Chiao, F. Dirbas, G. Somlo, R. Pera, K. Lao, M. Clarke (2009)
Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem CellsCell, 138
-
C. Bracken, P. Gregory, Natasha Kolesnikoff, A. Bert, Jun Wang, M. Shannon, G. Goodall (2008)
A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition.Cancer research, 68 19
- Publisher
- Springer Journals
- Copyright
- Copyright © 2009 by Nature Publishing Group
- Subject
- Life Sciences; Life Sciences, general; Cell Biology; Cancer Research; Developmental Biology; Stem Cells
- ISSN
- 1465-7392
- eISSN
- 1476-4679
- DOI
- 10.1038/ncb1998
- Publisher site
- See Article on Publisher Site
Abstract
The epithelial-to-mesenchymal transition transcription factor ZEB1 is involved in metastasis. It is now shown to regulate the tumour-initiating capacity of pancreatic and colorectal cancer cells, through the repression of the stemness-inhibiting miR200s, which are found to inhibit the polycomb repressor Bmi-1.
Journal
Nature Cell Biology – Springer Journals
Published: Nov 22, 2009