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The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the... Downloaded from Downloaded from Downloaded from genesdev.cshlp.org genesdev.cshlp.org genesdev.cshlp.org on November 15, 2021 - Published by on November 15, 2021 - Published by on November 15, 2021 - Published by Cold Spring Harbor Laboratory Press Cold Spring Harbor Laboratory Press Cold Spring Harbor Laboratory Press The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2 1 2 3 1,4 Sun-Mi Park, Arti B. Gaur, Ernst Lengyel, and Marcus E. Peter 1 2 The Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA; Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03755, USA; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, The University of Chicago, Chicago, Illinois 60637, USA Cancer progression has similarities with the process of epithelial-to-mesenchymal transition (EMT) found during embryonic development, during which cells down-regulate E-cadherin and up-regulate Vimentin expression. By evaluating the expression of 207 microRNAs (miRNAs) in the 60 cell lines of the drug screening panel maintained by the Nation Cancer Institute, we identified the miR-200 miRNA family as an extraordinary marker for cells that express E-cadherin but lack expression of Vimentin. These findings were extended to primary ovarian cancer http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

Park, Sun-Mi; Gaur, Arti B.; Lengyel, Ernst; Peter, Marcus E.
Genes & Development – Apr 1, 2008
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Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.1640608
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Abstract

Downloaded from Downloaded from Downloaded from genesdev.cshlp.org genesdev.cshlp.org genesdev.cshlp.org on November 15, 2021 - Published by on November 15, 2021 - Published by on November 15, 2021 - Published by Cold Spring Harbor Laboratory Press Cold Spring Harbor Laboratory Press Cold Spring Harbor Laboratory Press The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2 1 2 3 1,4 Sun-Mi Park, Arti B. Gaur, Ernst Lengyel, and Marcus E. Peter 1 2 The Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA; Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03755, USA; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, The University of Chicago, Chicago, Illinois 60637, USA Cancer progression has similarities with the process of epithelial-to-mesenchymal transition (EMT) found during embryonic development, during which cells down-regulate E-cadherin and up-regulate Vimentin expression. By evaluating the expression of 207 microRNAs (miRNAs) in the 60 cell lines of the drug screening panel maintained by the Nation Cancer Institute, we identified the miR-200 miRNA family as an extraordinary marker for cells that express E-cadherin but lack expression of Vimentin. These findings were extended to primary ovarian cancer

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Genes & Development – Unpaywall

Published: Apr 1, 2008

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