Access the full text.
Sign up today, get DeepDyve free for 14 days.
D. Burn, M. Mark, E. Playford, D. Maraganore, T. Zimmerman, R. Duvoisin, A. Harding, C. Marsden, D. Brooks (1992)
Parkinson's disease in twins studied with 18F‐dopa and positron emission tomographyNeurology, 42
D. Morgan, D. Diamond, P. Gottschall, K. Ugen, C. Dickey, J. Hardy, K. Duff, P. Jantzen, G. Dicarlo, D. Wilcock, K. Connor, J. Hatcher, C. Hope, M. Gordon, G. Arendash (2000)
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.Nature, 408 6815
O. Murayama, T. Tomita, N. Nihonmatsu, M. Murayama, X. Sun, T. Honda, T. Iwatsubo, A. Takashima (1999)
Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease.Neuroscience letters, 265 1
E. Check (2002)
Nerve inflammation halts trial for Alzheimer's drugNature, 415
Siu Li, U. Lindenberger (1999)
Cross-level unification: A computational exploration of the link between deterioration of neurotrans
M. Funayama, K. Hasegawa, H. Kowa, M. Saito, S. Tsuji, F. Obata (2002)
A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2–q13.1Annals of Neurology, 51
Y. Izumi, H. Morino, M. Oda, H. Maruyama, F. Udaka, M. Kameyama, Sigenobu Nakamura, H. Kawakami (2001)
Genetic studies in Parkinson's disease with an α-synuclein/NACP gene polymorphism in JapanNeuroscience Letters, 300
P. Bruhn, O. Parsons (1977)
Reaction Time Variability in Epileptic and Brain-Damaged PatientsCortex, 13
E. Louis, S. Fahn (1996)
Pathologically diagnosed diffuse Lewy body disease and Parkinson's disease. Do the parkinsonian features differ?Advances in neurology, 69
P. Morrish, J. Rakshi, D. Bailey, G. Sawle, D. Brooks (1998)
Measuring the rate of progression and estimating the preclinical period of Parkinson’s disease with [18F]dopa PETJournal of Neurology, Neurosurgery & Psychiatry, 64
H. Eysenck, M. Berger (1982)
A Model for intelligenceAmerican Journal of Psychology, 96
S. Sveinbjörnsdóttir, Andrew Hicks, Thorlákur Jónsson, H. Pétursson, Grétar Guðmundsson, M. Frigge, A. Kong, J. Gulcher, K. Stefánsson (2000)
Familial aggregation of Parkinson's disease in Iceland.The New England journal of medicine, 343 24
D. Hultsch, S. MacDonald, R. Dixon (2002)
Variability in reaction time performance of younger and older adults.The journals of gerontology. Series B, Psychological sciences and social sciences, 57 2
M. Spillantini, R. Crowther, R. Jakes, N. Cairns, P. Lantos, M. Goedert (1998)
Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies.Neuroscience letters, 251 3
L. Farrer, L. Cupples, J. Haines, B. Hyman, W. Kukull, R. Mayeux, R. Myers, M. Pericak-Vance, N. Risch, C. Duijn (1997)
Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysisJAMA, 278
M. Wolfe, M. Wolfe, W. Xia, B. Ostaszewski, T. Diehl, W. Kimberly, D. Selkoe (1999)
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activityNature, 398
I. Creveaux, B. Dastugue (1998)
[Apolipoprotein E and Alzheimer's disease].Annales de biologie clinique, 56 2
A. Paivio, J. Yuille, S. Madigan (1968)
Concreteness, imagery, and meaningfulness values for 925 nouns.Journal of experimental psychology, 76 1
D. Campion, C. Dumanchin, D. Hannequin, B. Dubois, S. Belliard, M. Puel, C. Thomas-Antérion, A. Michon, Cosette Martin, F. Charbonnier, G. Raux, A. Camuzat, C. Penet, Valérie Mesnage, Maria Martinez, F. Clerget-Darpoux, A. Brice, T. Frebourg (1999)
Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum.American journal of human genetics, 65 3
W. Esler, M. Wolfe (2001)
A Portrait of Alzheimer Secretases--New Features and Familiar FacesScience, 293
Linda Collins, Charles Long (1996)
Visual reaction time and its relationship to neuropsychological test performance.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 11 7
K. Anstey (1999)
Sensorimotor Variables and Forced Expiratory Volume as Correlates of Speed, Accuracy, and Variability in Reaction Time Performance in Late AdulthoodAging Neuropsychology and Cognition, 6
N. Mehta, L. Refolo, C. Eckman, S. Sanders, D. Yager, J. Pérez-Tur, S. Younkin, K. Duff, J. Hardy, M. Hutton (1998)
Increased Aβ42(43) from cell lines expressing presenilin 1 mutationsAnnals of Neurology, 43
S. Huber, H. Shulman, G. Paulson, EDWIN Shuttleworth (1989)
Dose‐dependent memory impairment in Parkinson's diseaseNeurology, 39
S. Seshadri, D. Drachman, C. Lippa (1995)
Apolipoprotein E epsilon 4 allele and the lifetime risk of Alzheimer's disease. What physicians know, and what they should know.Archives of neurology, 52 11
(1928)
THE LESSONS OF RARE MALADIESBritish Medical Journal, 1
M. Citron (2002)
β‐secretase as a target for the treatment of Alzheimer's diseaseJournal of Neuroscience Research, 70
T. Gasser, B. Müller-Myhsok, Z. Wszolek, R. Oehlmann, D. Calne, V. Bonifati, B. Bereznai, E. Fabrizio, P. Vieregge, R. Horstmann (1998)
A susceptibility locus for Parkinson's disease maps to chromosome 2p13Nature Genetics, 18
K. Marder, M. Tang, H. Mejia, B. Alfaro, L. Cote, E. Louis, J. Groves, R. Mayeux (1996)
Risk of Parkinson's disease among first-degree relativesNeurology, 47
W. Scott, M. Nance, R. Watts, J. Hubble, W. Koller, Kelly Lyons, R. Pahwa, M. Stern, A. Colcher, B. Hiner, J. Jankovic, W. Ondo, F. Allen, C. Goetz, G. Small, Donna Masterman, F. Mastaglia, N. Laing, J. Stajich, B. Slotterbeck, M. Booze, R. Ribble, E. Rampersaud, S. West, R. Gibson, L. Middleton, A. Roses, J. Haines, B. Scott, J. Vance, M. Pericak-Vance (2001)
Complete genomic screen in Parkinson disease: evidence for multiple genes.JAMA, 286 18
M. Farrer, D. Maraganore, P. Lockhart, A. Singleton, T. Lesnick, M. Andrade, A. West, R. Silva, J. Hardy, D. Hernandez (2001)
α-synuclein gene haplotypes are associated with Parkinson’s diseaseHuman Molecular Genetics, 10
H. Hendrie, A. Ogunniyi, K. Hall, O. Baiyewu, F. Unverzagt, O. Gureje, Sujuan Gao, R. Evans, A. Ogunseyinde, Abiodun Adeyinka, Beverly Musick, S. Hui (2001)
Incidence of dementia and Alzheimer disease in 2 communities: Yoruba residing in Ibadan, Nigeria, and African Americans residing in Indianapolis, Indiana.JAMA, 285 6
E. Leroy, R. Boyer, G. Auburger, B. Leube, G. Ulm, É. Mezey, G. Harta, M. Brownstein, Sobhanadditya Jonnalagada, Tanya Chernova, A. Dehejia, C. Lavedan, T. Gasser, P. Steinbach, K. Wilkinson, M. Polymeropoulos (1998)
The ubiquitin pathway in Parkinson's diseaseNature, 395
A. Slifkin, K. Newell (1998)
Is Variability in Human Performance a Reflection of System Noise?Current Directions in Psychological Science, 7
P. Chapman, A. Falinska, S. Knevett, M. Ramsay (2001)
Genes, models and Alzheimer's disease.Trends in genetics : TIG, 17 5
A. Hughes, S. Daniel, L. Kilford, A. Lees, London Wcln, J. Hughes (1992)
Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.Journal of Neurology, Neurosurgery & Psychiatry, 55
T. Yamazaki, Y. Ihara (1997)
Molecular pathology of Alzheimer's diseaseNeuropathology, 17
H. Payami, Kimberly Larsen, Steven Bernard, J. Nutt (1994)
Increased risk of Parkinson's disease in parents and siblings of patientsAnnals of Neurology, 36
M. Farrer, P. Chan, Rong-hui Chen, L. Tan, S. Lincoln, D. Hernandez, L. Forno, K. Gwinn‐Hardy, L. Petrucelli, J. Hussey, A. Singleton, C. Tanner, J. Hardy, J. Langston (2001)
Lewy bodies and parkinsonism in families with parkin mutationsAnnals of Neurology, 50
D. Morgan, D. Diamond, P. Gottschall, K. Ugen, C. Dickey, J. Hardy, K. Duff, P. Jantzen, G. Dicarlo, D. Wilcock, K. Connor, J. Hatcher, C. Hope, M. Gordon, G. Arendash (2000)
Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's diseaseNature, 408
E. Gómez-Tortosa, K. Newell, M. Irizarry, B. Hyman (1998)
Clinical and neuropathological features of dementia with Lewy bodiesAmerican Journal of Alzheimer's Disease and Other Dementias, 13
T. Kitada, S. Asakawa, N. Hattori, H. Matsumine, Y. Yamamura, S. Minoshima, M. Yokochi, Y. Mizuno, N. Shimizu (1998)
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonismNature, 392
M. Hutton, C. Lendon, P. Rizzu, M. Baker, S. Froelich, H. Houlden, S. Pickering-Brown, S. Chakraverty, A. Isaacs, A. Grover, J. Hackett, J. Adamson, S. Lincoln, D. Dickson, P. Davies, R. Petersen, M. Stevens, E. Graaff, E. Wauters, J. Baren, M. Hillebrand, M. Joosse, J. Kwon, P. Nowotny, Li Che, J. Norton, J. Morris, L. Reed, J. Trojanowski, H. Basun, L. Lannfelt, M. Neystat, S. Fahn, F. Dark, T. Tannenberg, P. Dodd, N. Hayward, J. Kwok, P. Schofield, A. Andreadis, J. Snowden, D. Craufurd, D. Neary, F. Owen, B. Oostra, J. Hardy, A. Goate, J. Swieten, D. Mann, T. Lynch, P. Heutink (1998)
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17Nature, 393
Shu-Chen Li, S. Aggen, J. Nesselroade, P. Baltes (2001)
Short-Term Fluctuations in Elderly People’s Sensorimotor Functioning Predict Text and Spatial Memory Performance: The MacArthur Successful Aging StudiesGerontology, 47
D. Borchelt, G. Thinakaran, C. Eckman, Michael Lee, F. Davenport, T. Ratovitsky, C. Prada, Grace Kim, S. Seekins, D. Yager, H. Slunt, Rong Wang, M. Seeger, A. Levey, S. Gandy, N. Copeland, N. Jenkins, D. Price, S. Younkin, S. Sisodia (1996)
Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In VivoNeuron, 17
T. Lynch, M. Sano, K. Marder, K. Bell, N. Foster, R. Defending, A. Sima, C. Keohane, T. Nygaard, S. Fahn, R. Mayeux, L. Rowland, K. Wilhelmsen (1994)
Clinical characteristics of a family with chromosome 17‐linked disinhibition‐dementia‐ parkinsonism‐amyotrophy complexNeurology, 44
L. Holcomb, M. Gordon, E. McGowan, Xin Yu, S. Benkovic, P. Jantzen, K. Wright, Irene Saad, R. Mueller, D. Morgan, S. Sanders, C. Zehr, Kassandra O'Campo, J. Hardy, C. Prada, C. Eckman, S. Younkin, K. Hsiao, K. Duff (1998)
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenesNature Medicine, 4
D. Scheuner, C. Eckman, C. Eckman, M. Jensen, X. Song, M. Citron, N. Suzuki, T. Bird, J. Hardy, M. Hutton, W. Kukull, Eric Larson, E. Levy-Lahad, M. Viitanen, E. Peskind, P. Poorkaj, G. Schellenberg, R. Tanzi, W. Wasco, L. Lannfelt, D. Selkoe, S. Younkin (1996)
Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's diseaseNature Medicine, 2
(1988)
Lewy bodies are ubiquitinated : a light and electron microscopic immunocytochemical study
C. Luis, W. Mittenberg, C. Gass, R. Duara (1999)
Diffuse Lewy Body Disease: Clinical, Pathological, and Neuropsychological ReviewNeuropsychology Review, 9
D. Delis, L. Direnfeld, M. Alexander, E. Kaplan (1982)
Cognitive fluctuations associated with on‐off phenomenon in Parkinson diseaseNeurology, 32
C. Eckman, C. Eckman, N. Mehta, N. Mehta, R. Crook, R. Crook, J. Pérez-Tur, J. Pérez-Tur, G. Prihar, G. Prihar, Eric Pfeiffer, N. Graff-Radford, Paul Hinder, D. Yager, B. Zenk, L. Refolo, C. Prada, S. Younkin, M. Hutton, M. Hutton, J. Hardy, J. Hardy (1997)
A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43).Human molecular genetics, 6 12
A. Saunders, C. Hulette, K. Welsh-Bohmer, D. Schmechel, B. Crain, J. Burke, M. Alberts, W. Strittmatter, J. Breitner, C. Rosenberg, S. Scott, PC Gaskell, M. Pericak-Vance, A. Roses (1996)
Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's diseaseThe Lancet, 348
M. Folstein, M. Folstein, S. Folstein, S. Folstein, P. McHugh, P. McHugh (1975)
“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinicianJournal of Psychiatric Research, 12
V. Bonifati, P. Rizzu, M. Baren, O. Schaap, G. Breedveld, E. Krieger, M. Dekker, F. Squitieri, P. Ibáñez, M. Joosse, J. Dongen, N. Vanacore, J. Swieten, A. Brice, G. Meco, C. Duijn, B. Oostra, P. Heutink (2002)
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset ParkinsonismScience, 299
M. Aronson, W. Ooi, Dalia Geva, D. Masur, A. Blau, W. Frishman (1991)
Dementia. Age-dependent incidence, prevalence, and mortality in the old old.Archives of internal medicine, 151 5
N. Abbas, Christoph Lü, S. Ricard, A. Dürr, V. Bonifati, G. Michele, S. Bouley, Jenny ughan, T. Gasser, R. Marconi, E. Broussolle, C. Brefel‐Courbon, B. Harhangi, B. Oostra, Edito izio, G. Böhme, L. Pradier, N. Wood, Alessandro illa, G. Meco, P. Denéfle, Y. Agid, Alexis ice (1999)
A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease.Human molecular genetics, 8 4
M. Pollanen, D. Dickson, C. Bergeron (1993)
Pathology and Biology of the Lewy BodyJournal of Neuropathology and Experimental Neurology, 52
O. Murayama, T. Tomita, N. Nihonmatsu, M. Murayama, Xiaoyan Sun, T. Honda, T. Iwatsubo, A. Takashima (1999)
Enhancement of amyloid β 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's diseaseNeuroscience Letters, 265
H. Shimura, M. Schlossmacher, N. Hattori, M. Frosch, A. Trockenbacher, R. Schneider, Y. Mizuno, K. Kosik, D. Selkoe (2001)
Ubiquitination of a New Form of α-Synuclein by Parkin from Human Brain: Implications for Parkinson's DiseaseScience, 293
É. Mezey, A. Dehejia, G. Harta, S. Suchy, R. Nussbaum, M. Brownstein, M. Polymeropoulos (1998)
Alpha synuclein is present in Lewy bodies in sporadic Parkinson's diseaseMolecular Psychiatry, 3
A. Myers, A. Goate (2001)
The genetics of late-onset Alzheimer's diseaseCurrent Opinion in Neurology, 14
C. Tanner, R. Ottman, S. Goldman, J. Ellenberg, P. Chan, R. Mayeux, J. Langston (1999)
Parkinson disease in twins: an etiologic study.JAMA, 281 4
T. Iwatsubo, A. Odaka, N. Suzuki, H. Mizusawa, N. Nukina, Y. Ihara (1994)
Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).Neuron, 13 1
F. Girotti, F. Carella, M. Grassi, P. Soliveri, R. Marano, T. Caraceni (1986)
Motor and cognitive performances of parkinsonian patients in the on and off phases of the disease.Journal of Neurology, Neurosurgery & Psychiatry, 49
Y. Izumi, H. Morino, M. Oda, H. Maruyama, F. Udaka, M. Kameyama, S. Nakamura, H. Kawakami (2001)
Genetic studies in Parkinson's disease with an alpha-synuclein/NACP gene polymorphism in Japan.Neuroscience letters, 300 2
M. Farrer, D. Maraganore, P. Lockhart, A. Singleton, T. Lesnick, M. Andrade, A. West, R. Silva, J. Hardy, D. Hernandez (2001)
alpha-Synuclein gene haplotypes are associated with Parkinson's disease.Human molecular genetics, 10 17
L. Helmuth (2000)
Further Progress on a β-Amyloid VaccineScience, 289
M. Citron (2002)
Beta-secretase as a target for the treatment of Alzheimer's disease.Journal of neuroscience research, 70 3
R. Krüger, A. Vieira‐Saecker, W. Kuhn, D. Berg, T. Müller, N. Kühnl, G. Fuchs, A. Storch, M. Hungs, D. Woitalla, H. Przuntek, J. Epplen, L. Schöls, O. Riess (1999)
Increased susceptibility to sporadic Parkinson's disease by a certain combined α‐synuclein/apolipoprotein E genotypeAnnals of Neurology, 45
J. Kim, J. Nesselroade, D. Featherman (1996)
The state component in self-reported worldviews and religious beliefs of older adults: the MacArthur Successful Aging Studies.Psychology and aging, 11 3
S. Seshadri, D. Drachman, C. Lippa (1995)
Apolipoprotein E ε4 allele and the lifetime risk of Alzheimer's disease : what physicians know, and what they should knowJAMA Neurology, 52
H. Matsumine, M. Saito, S. Shimoda-Matsubayashi, Hajime Tanaka, A. Ishikawa, Y. Nakagawa‐Hattori, M. Yokochi, Tomonori, Kobayashi, S. Igarashi, H. Takano, Kazuhiro, Sanpei, R. Koike, Hideo Mori, T. Kondo, Y. Mizutani, Alejandro, A., Schaffer, Yasuhiro, Yamamura, Shigenobu Nakamura, S. Kuzuhara, Shoji, Tsuji, Y. Mizuno (1997)
Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27.American journal of human genetics, 60 3
D. Moechars, K. Lorent, B. Strooper, I. Dewachter, F. Leuven (1996)
801 Expression in brain of Amyloid Precursor Protein mutated in the α-secretase site, causes disturbed behavior, neuronal degeneration and premature death in transgenic miceNeurobiology of Aging, 17
E. Strauss, S. MacDonald, M. Hunter, A. Moll, D. Hultsch (2002)
Intraindividual variability in cognitive performance in three groups of older adults: Cross-domain links to physical status and self-perceived affect and beliefsJournal of the International Neuropsychological Society, 8
T. Iwatsubo, A. Odaka, N. Suzuki, H. Mizusawa, N. Nukina, Y. Ihara (1994)
Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)Neuron, 13
(2001)
An inflammatory drug prospect
D. Schenk, R. Barbour, W. Dunn, G. Gordon, H. Grajeda, T. Guido, K. Hu, Jiping Huang, K. Johnson-wood, K. Khan, D. Kholodenko, Mike Lee, Zhenmei Liao, I. Lieberburg, R. Motter, L. Mutter, F. Soriano, G. Shopp, N. Vasquez, C. Vandevert, S. Walker, M. Wogulis, T. Yednock, D. Games, P. Seubert (1999)
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouseNature, 400
K. Birmingham, S. Frantz (2002)
Set back to Alzheimer vaccine studiesNature Medicine, 8
C. Lücking, A. Durr, Bonifati, J. Vaughan, G. Michele, T. Gasser, B. Harhangi, G. Meco, P. Denéfle, N. Wood, Y. Agid, A. Brice, French Stu (2000)
Association between early-onset Parkinson's disease and mutations in the parkin gene.The New England journal of medicine, 342 21
Joseph Martin (1999)
Molecular basis of the neurodegenerative disorders.The New England journal of medicine, 340 25
M. Farrer, K. Gwinn‐Hardy, M. Muenter, Fabienne DeVriéze, R. Crook, J. Pérez-Tur, S. Lincoln, D. Maraganore, C. Adler, Stephanie Newman, Kari MacElwee, Page McCarthy, C. Miller, C. Waters, John Hardy (1999)
A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor.Human molecular genetics, 8 1
E. Mori (2000)
[Dementia with Lewy bodies].Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 37 10
M. Spillantini, M. Schmidt, V. Lee, J. Trojanowski, R. Jakes, M. Goedert (1997)
α-Synuclein in Lewy bodiesNature, 388
C. Duijn, M. Dekker, V. Bonifati, R. Galjaard, Jeanine Houwing‐Duistermaat, P. Snijders, L. Testers, G. Breedveld, M. Horstink, L. Sandkuijl, J. Swieten, B. Oostra, P. Heutink (2001)
Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36.American journal of human genetics, 69 3
C. Reed (1998)
Evidence for movement preprogramming and on line control in differentially impaired patients with Parkinson's disease.Cognitive neuropsychology, 15 6-8
D. Nelson, D. Bennett, Todd Leibert (1997)
One step is not enough: Making better use of association norms to predict cued recallMemory & Cognition, 25
D. Scheuner, C. Eckman, M. Jensen, X. Song, M. Citron, N. Suzuki, T. Bird, J. Hardy, M. Hutton, W. Kukull, E. Larson, E. Levy-Lahad, M. Viitanen, E. Peskind, P. Poorkaj, G. Schellenberg, R. Tanzi, W. Wasco, L. Lannfelt, D. Selkoe, S. Younkin (1996)
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.Nature medicine, 2 8
S. Murtha, R. Cismaru, R. Waechter, H. Chertkow (2002)
Increased variability accompanies frontal lobe damage in dementiaJournal of the International Neuropsychological Society, 8
H. Steiner, C. Haass (2000)
Intramembrane proteolysis by presenilinsNature Reviews Molecular Cell Biology, 1
M. Polymeropoulos, C. Lavedan, E. Leroy, S. Ide, A. Dehejia, A. Dutra, B. Pike, H. Root, J. Rubenstein, R. Boyer, E. Stenroos, S. Chandrasekharappa, A. Athanassiadou, T. Papapetropoulos, W. Johnson, A. Lazzarini, R. Duvoisin, G. Iorio, L. Golbe, R. Nussbaum (1997)
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.Science, 276 5321
(2000)
Prevalence of AD among whites: a summary by levels of severity
Andrew Hicks, H. Petursson, Thorlákur Jónsson, H. Stefánsson, Hrefna Johannsdottir, J. Sainz, M. Frigge, A. Kong, J. Gulcher, K. Stefánsson, S. Sveinbjörnsdóttir (2002)
A susceptibility gene for late‐onset idiopathic Parkinson's diseaseAnnals of Neurology, 52
D. Stuss, J. Pogue, L. Buckle, Jay Bondar (1994)
Characterization of stability of performance in patients with traumatic brain injury: Variability and consistency on reaction time tests.Neuropsychology (journal), 8
P. Piccini, P. Piccini, P. Morrish, N. Turjanski, G. Sawle, D. Burn, R. Weeks, M. Mark, D. Maraganore, A. Lees, D. Brooks (1997)
Dopaminergic function in familial Parkinson's disease: A clinical and 18F‐dopa positron emission tomography studyAnnals of Neurology, 41
J. Galvin, V. Lee, J. Trojanowski (2001)
Synucleinopathies: clinical and pathological implications.Archives of neurology, 58 2
R. Duvoisin, W. Johnson (1992)
Hereditary Lewy‐Body Parkinsonism and Evidence for a Genetic Etiology of Parkinson's DiseaseBrain Pathology, 2
L. Farrer, L. Cupples, J. Haines, B. Hyman, W. Kukull, R. Mayeux, R. Myers, M. Pericak-Vance, N. Risch, C. Duijn (1997)
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.JAMA, 278 16
N. Pankratz, W. Nichols, Sean Uniacke, C. Halter, A. Rudolph, C. Shults, C. Shults, P. Conneally, T. Foroud (2002)
Genome screen to identify susceptibility genes for Parkinson disease in a sample without parkin mutations.American journal of human genetics, 71 1
L. Helmuth (2000)
Alzheimer's congress. Further progress on a beta-amyloid vaccine.Science, 289 5478
M. Spillantini, R. Crowther, R. Jakes, N. Cairns, P. Lantos, M. Goedert (1998)
Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodiesNeuroscience Letters, 251
C. Helmer, P. Joly, L. Letenneur, D. Commenges, J. Dartigues (2001)
Mortality with dementia: results from a French prospective community-based cohort.American journal of epidemiology, 154 7
E. Valente, A. Bentivoglio, P. Dixon, A. Ferraris, T. Ialongo, M. Frontali, A. Albanese, N. Wood (2001)
Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36.American journal of human genetics, 68 4
R. Krüger, W. Kuhn, T. Müller, D. Woitalla, M. Graeber, S. Kösel, H. Przuntek, J. Epplen, L. Schöls, O. Riess (1998)
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.Nature genetics, 18 2
M. Meyer, J. Tschanz, M. Norton, K. Welsh-Bohmer, D. Steffens, B. Wyse, J. Breitner (1998)
APOE genotype predicts when — not whether — one is predisposed to develop Alzheimer diseaseNature Genetics, 19
P. Knotek, K. Bayles, A. Kaszniak (1990)
Response consistency on a semantic memory task in persons with dementia of the Alzheimer typeBrain and Language, 38
C. Hertzog, R. Dixon, D. Hultsch (1992)
Intraindividual change in text recall of the elderlyBrain and Language, 42
T. Crawford, S. Goodrich, L. Henderson, C. Kennard (1989)
Predictive responses in Parkinson's disease: manual keypresses and saccadic eye movements to regular stimulus events.Journal of Neurology, Neurosurgery & Psychiatry, 52
C. Lücking, N. Abbas, A. Dürr, Vincenzo Bonifati, A. Bonnet, T. Broucker, G. Michele, N. Wood, Y. Agid, Alexis Brice (1998)
Homozygous deletions in parkin gene in European and North African families with autosomal recessive juvenile parkinsonismThe Lancet, 352
M. Polymeropoulos, C. Lavedan, E. Leroy, S. Ide, A. Dehejia, A. Dutra, B. Pike, H. Root, J. Rubenstein, R. Boyer, E. Stenroos, S. Chandrasekharappa, A. Athanassiadou, T. Papapetropoulos, W. Johnson, A. Lazzarini, R. Duvoisin, G. Iorio, L. Golbe, R. Nussbaum (1997)
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's DiseaseScience, 276
E. Tan, T. Matsuura, S. Nagamitsu, M. Khajavi, J. Jankovic, T. Ashizawa (2000)
Polymorphism of NACP-Rep1 in Parkinson’s disease: An etiologic link with essential tremor?Neurology, 54
K. Conway, Seung Lee, J. Rochet, T. Ding, Robin Williamson, P. Lansbury (2000)
Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy.Proceedings of the National Academy of Sciences of the United States of America, 97 2
Although most cases of Alzheimer's and Parkinson's disease are sporadic, some cases are clearly familial. This review, part of the Genomic Medicine series, examines the genetics of these familial forms. Although the inherited forms are rare, the knowledge derived from investigating their pathobiology has improved our understanding of the pathobiology of the more common, sporadic forms of the diseases.
The New England Journal of Medicine – The New England Journal of Medicine
Published: Apr 3, 2003
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.