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- Publisher
- Oxford University Press
- Copyright
- Copyright © 2015 Oxford University Press
- ISSN
- 0964-6906
- eISSN
- 1460-2083
- DOI
- 10.1093/hmg/10.17.1847
- Publisher site
- See Article on Publisher Site
Abstract
We report haplotype analysis of the α-synuclein gene in Parkinson’s disease (PD), extending earlier reports of an association with a polymorphism within the gene promoter. This analysis showed significant differences in haplotypes between PD cases and controls. Our analyses demonstrate that genetic variability in the α-synuclein gene is a risk factor for the development of PD. These genetic findings are analogous to the tau haplotype over-represented in progressive supranuclear palsy and further extend the similarity in the etiologies and pathogeneses of the synucleinopathies and tauopathies. Received May 9, 2001; Revised and Accepted June 18, 2001. « Previous | Next Article » Table of Contents This Article Hum. Mol. Genet. (2001) 10 (17): 1847-1851. doi: 10.1093/hmg/10.17.1847 » Abstract Free Full Text (HTML) Free Full Text (PDF) Free Classifications Report Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Similar articles in PubMed Add to my archive Download citation Request Permissions Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Farrer, M. Articles by Hernandez, D. Search for related content PubMed PubMed citation Articles by Farrer, M. Articles by Maraganore, D. M. Articles by Lockhart, P. Articles by Singleton, A. Articles by Lesnick, T. Articles by de Andrade, M. Articles by West, A. Articles by de Silva, R. Articles by Hardy, J. Articles by Hernandez, D. 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Journal
Human Molecular Genetics – Oxford University Press
Published: Aug 15, 2001