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Interferon-Induced Cutaneous Necrosis

Interferon-Induced Cutaneous Necrosis Background:Due to advances in recombinant DNA technology, interferons are now readily available and are frequently used in all branches of medicine. These potent biologic response modifiers carry a number of systemic and local side effects. These cytokines are usually administered subcutaneously, and recent studies have described the occurrence of inflammation or necrosis at the site of injection.Objective:We report a case of cutaneous necrosis at the sites of interferon injections in a 35-year-old man treated for chronic myeloid leukemia with high, daily doses of interferon alfa. In addition, we review the existing literature on interferon-induced cutaneous necrosis and discuss preventive strategies.Conclusion:Cutaneous inflammation or necrosis at interferon injection sites is not uncommon. Although interferon beta-lb is most commonly responsible for this complication, it is now increasingly reported with interferon alfa. It appears to be secondary to the proinflammatory effects of these cytokines or to their unmasking of a subtle hyper-coagulable state. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cutaneous Medicine and Surgery SAGE

Interferon-Induced Cutaneous Necrosis

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References (32)

Publisher
SAGE
Copyright
© 1999 Canadian Dermatology Association
ISSN
1203-4754
eISSN
1615-710X
DOI
10.1177/120347549900300610
pmid
10575164
Publisher site
See Article on Publisher Site

Abstract

Background:Due to advances in recombinant DNA technology, interferons are now readily available and are frequently used in all branches of medicine. These potent biologic response modifiers carry a number of systemic and local side effects. These cytokines are usually administered subcutaneously, and recent studies have described the occurrence of inflammation or necrosis at the site of injection.Objective:We report a case of cutaneous necrosis at the sites of interferon injections in a 35-year-old man treated for chronic myeloid leukemia with high, daily doses of interferon alfa. In addition, we review the existing literature on interferon-induced cutaneous necrosis and discuss preventive strategies.Conclusion:Cutaneous inflammation or necrosis at interferon injection sites is not uncommon. Although interferon beta-lb is most commonly responsible for this complication, it is now increasingly reported with interferon alfa. It appears to be secondary to the proinflammatory effects of these cytokines or to their unmasking of a subtle hyper-coagulable state.

Journal

Journal of Cutaneous Medicine and Surgery – SAGE

Published: Oct 1, 1999

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