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References (80)
-
L. Obert, F. Deschaseaux, P. Garbuio (2005)
Critical analysis and efficacy of BMPs in long bones non-union.Injury, 36 Suppl 3
-
M. Macnicol (2001)
Patterns of musculoskeletal infection in childhood.The Journal of bone and joint surgery. British volume, 83 1
-
M. Bosse, E. Mackenzie, J. Kellam, A. Burgess, L. Webb, M. Swiontkowski, R. Sanders, A. Jones, M. McAndrew, B. Patterson, M. Mccarthy, T. Travison, R. Castillo (2002)
An analysis of outcomes of reconstruction or amputation after leg-threatening injuries.The New England journal of medicine, 347 24
-
Bramlage Bramlage, Haupl Haupl, Kaps Kaps, Bramlage Bramlage, Muller Muller, Strutz Strutz (2005)
(Bone morphogenetic proteins in the skeletal system.)Z Rheumatol, 64
-
U. Ripamonti (2005)
Bone induction by recombinant human osteogenic protein‐1 (hOP‐1, BMP‐7) in the primate Papio ursinus with expression of mRNA of gene products of the TGF‐β superfamilyJournal of Cellular and Molecular Medicine, 9
-
L. Jackson, P. Pacchiana (2004)
Common complications of fracture repair.Clinical techniques in small animal practice, 19 3
-
P. Issack, P. Dicesare (2003)
Recent advances toward the clinical application of bone morphogenetic proteins in bone and cartilage repair.American journal of orthopedics, 32 9
-
J. Wozney (2002)
Overview of Bone Morphogenetic ProteinsSpine, 27
-
J. Lieberman, A. Daluiski, T. Einhorn (2002)
The role of growth factors in the repair of bone. Biology and clinical applications.The Journal of bone and joint surgery. American volume, 84 6
-
J. Massagué, F. Weis-Garcia (1996)
Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals.Cancer surveys, 27
-
T. Einhorn (1998)
The cell and molecular biology of fracture healing.Clinical orthopaedics and related research, 355 Suppl
-
Di Chen, Ming Zhao, G. Mundy (2004)
Bone Morphogenetic ProteinsGrowth Factors, 22
-
M. Urist (1965)
Bone: Formation by AutoinductionScience, 150
-
Roman Hayda, Carl Brighton, J. Esterhai (1998)
Pathophysiology of delayed healing.Clinical orthopaedics and related research, 355 Suppl
-
G. Friedlaender, C. Perry, J. Cole, S. Cook, G. Cierny, G. Muschler, G. Zych, J. Calhoun, A. Laforte, Samuel Yin (2001)
Osteogenic Protein-1 (Bone Morphogenetic Protein-7) in the Treatment of Tibial Nonunions: A Prospective, Randomized Clinical Trial Comparing rhOP-1 with Fresh Bone Autograft*The Journal of Bone & Joint Surgery, 83
-
M. Swiontkowski, H. Aro, S. Donell, J. Esterhai, J. Goulet, A. Jones, P. Kregor, L. Nordsletten, G. Paiement, Amratlal Patel (2006)
Recombinant human bone morphogenetic protein-2 in open tibial fractures. A subgroup analysis of data combined from two prospective randomized studies.The Journal of bone and joint surgery. American volume, 88 6
-
S. Govender, K. Kumar, Orthopaedic Orth, Surgeon (2002)
Staged reduction and stabilisation in chronic atlantoaxial rotatory fixation.The Journal of bone and joint surgery. British volume, 84 5
-
H. Yamashita, H. Yamashita, P. Dijke, C. Heldin, K. Miyazono (1996)
Bone morphogenetic protein receptors.Bone, 19 6
-
Martin Lind (1998)
Growth factor stimulation of bone healing. Effects on osteoblasts, osteomies, and implants fixation.Acta orthopaedica Scandinavica. Supplementum, 283
-
T. Branfoot (2005)
Research directions for bone healing.Injury, 36 Suppl 3
-
M. Kanayama, T. Hashimoto, K. Shigenobu, S. Yamane, Thomas Bauer, D. Togawa (2006)
A Prospective Randomized Study of Posterolateral Lumbar Fusion Using Osteogenic Protein-1 (OP-1) Versus Local Autograft With Ceramic Bone Substitute: Emphasis of Surgical Exploration and Histologic AssessmentSpine, 31
-
B. Hogan (1996)
Bone morphogenetic proteins: multifunctional regulators of vertebrate development.Genes & development, 10 13
-
N. Duneas, J. Crooks, U. Ripamonti (1998)
Transforming growth factor-beta 1: induction of bone morphogenetic protein genes expression during endochondral bone formation in the baboon, and synergistic interaction with osteogenic protein-1 (BMP-7).Growth factors, 15 4
-
H. Seeherman, Rebecca Li, J. Wozney (2003)
A Review of Preclinical Program Development for Evaluating Injectable Carriers for Osteogenic FactorsThe Journal of Bone & Joint Surgery, 85
-
P. Biase, R. Capanna (2005)
Clinical applications of BMPs.Injury, 36 Suppl 3
-
M. Kanatani, T. Sugimoto, H. Kaji, Tatsuya Kobayashi, Katsuhito Nishiyama, M. Fukase, M. Kumegawa, K. Chihara (1995)
Stimulatory effect of bone morphogenetic protein‐2 on osteoclast‐like cell formation and bone‐resorbing activityJournal of Bone and Mineral Research, 10
-
Hongwei Cheng, Wei Jiang, F. Phillips, R. Haydon, Ying Peng, Lan Zhou, H. Luu, N. An, B. Breyer, P. Vanichakarn, J. Szatkowski, Jae Park, T. He (2003)
Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs).The Journal of bone and joint surgery. American volume, 85 8
-
T. Einhorn (1995)
Enhancement of fracture-healing.The Journal of bone and joint surgery. American volume, 77 6
-
E. Abe (2006)
Function of BMPs and BMP Antagonists in Adult BoneAnnals of the New York Academy of Sciences, 1068
-
D. Nunamaker (1998)
Experimental models of fracture repair.Clinical orthopaedics and related research, 355 Suppl
-
(2009)
Tibial nonunionOrthopedic Trauma Directions, 7
-
T. Adachi, H. Takanaga, M. Kunimoto, H. Asou (2005)
Influence of LIF and BMP‐2 on differentiation and development of glial cells in primary cultures of embryonic rat cerebral hemisphereJournal of Neuroscience Research, 79
-
N. Udagawa (2004)
Mechanisms involved in bone resorptionBiogerontology, 3
-
M. Bhandari, G. Guyatt, M. Swiontkowski, P. Tornetta, S. Sprague, E. Schemitsch (2002)
A Lack of Consensus in the Assessment of Fracture Healing Among Orthopaedic SurgeonsJournal of Orthopaedic Trauma, 16
-
T. Makino, D. Hak, S. Hazelwood, S. Curtiss, A. Reddi (2005)
Prevention of atrophic nonunion development by recombinant human bone morphogenetic protein‐7Journal of Orthopaedic Research, 23
-
P. Harwood, P. Giannoudis (2005)
Application of bone morphogenetic proteins in orthopaedic practice: their efficacy and side effectsExpert Opinion on Drug Safety, 4
-
U. Ripamonti (2006)
Soluble osteogenic molecular signals and the induction of bone formation.Biomaterials, 27 6
-
Andrew White, M. Weinstein, T. Patel, M. Horowitz, G. Friedlaender (2004)
Lumbar Arthrodesis Gene Expression: A Comparison of Autograft with Osteogenic Protein-1Clinical Orthopaedics and Related Research, 1
-
U. Ripamonti (2004)
Soluble, insoluble and geometric signals sculpt the architecture of mineralized tissuesJournal of Cellular and Molecular Medicine, 8
-
A. Reddi (2001)
Bone Morphogenetic Proteins: From Basic Science to Clinical ApplicationsThe Journal of Bone & Joint Surgery, 83
-
M. Subramaniam, S. Jalal, D. Rickard, S. Harris, M. Bolander, T. Spelsberg (2002)
Further characterization of human fetal osteoblastic hFOB 1.19 and hFOB/ERα cells: Bone formation in vivo and karyotype analysis using multicolor fluorescent in situ hybridizationJournal of Cellular Biochemistry, 87
-
H. Terai, K. Takaoka (2006)
[Application of bone morphogenetic protein (BMP) in regenerative medicine of bone].Clinical calcium, 16 5
-
R. Westerhuis, R. Bezooijen, P. Kloen (2005)
Use of bone morphogenetic proteins in traumatology.Injury, 36 12
-
White White, Weinstein Weinstein, Patel Patel, Horowitz Horowitz, Friedlaender Friedlaender (2004)
The 2002 Marshall Urist Young Investigator Award Paper. Lumbar arthrodesis gene expression: a comparison of autograft with osteogenic protein‐1Clin. Orthop. Relat. Res, 429
-
Friedlaender Friedlaender, Perry Perry, Cole Cole (2001)
Osteogenic protein‐1 (bone morphogenetic protein‐7) in the treatment of tibial nonunionsJ. Bone Joint Surg. Am, 83‐A
-
P. Groscurth, L. Filgueira (1998)
Killing Mechanisms of Cytotoxic T Lymphocytes.News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society, 13
-
P. Giannoudis, C. Tzioupis (2005)
Clinical applications of BMP-7: the UK perspective.Injury, 36 Suppl 3
-
Ming Zhao, G. Xiao, J. Berry, R. Franceschi, A. Reddi, M. Somerman (2002)
Bone Morphogenetic Protein 2 Induces Dental Follicle Cells to Differentiate Toward a Cementoblast/Osteoblast PhenotypeJournal of Bone and Mineral Research, 17
-
R. Dimitriou, Z. Dahabreh, E. Katsoulis, S. Matthews, T. Branfoot, P. Giannoudis (2005)
Application of recombinant BMP-7 on persistent upper and lower limb non-unions.Injury, 36 Suppl 4
-
M. Ronga, F. Baldo, G. Zappalà, P. Cherubino (2006)
Recombinant human bone morphogenetic protein-7 for treatment of long bone non-union: an observational, retrospective, non-randomized study of 105 patients.Injury, 37 Suppl 3
-
E. Rodríguez‐Merchán, F. Forriol (2004)
Nonunion: general principles and experimental data.Clinical orthopaedics and related research, 419
-
E. Groeneveld, E. Burger (2000)
Bone morphogenetic proteins in human bone regeneration.European journal of endocrinology, 142 1
-
T. Suda, N. Takahashi, N. Udagawa, E. Jimi, M. Gillespie, T. Martin (1999)
Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families.Endocrine reviews, 20 3
-
M. Bostrom, N. Camacho (1998)
Potential Role of Bone Morphogenetic Proteins in Fracture HealingClinical Orthopaedics and Related Research, &NA;
-
A. Reddi (1998)
Initiation of fracture repair by bone morphogenetic proteins.Clinical orthopaedics and related research, 355 Suppl
-
Xinqian Chen, L. Kidder, W. Lew (2002)
Osteogenic protein‐1 induced bone formation in an infected segmental defect in the rat femurJournal of Orthopaedic Research, 20
-
H. Zou, Kwang-Min Choe, Y. Lu, J. Massagué, J. Massagué, L. Niswander (1997)
BMP signaling and vertebrate limb development.Cold Spring Harbor symposia on quantitative biology, 62
-
S. Govender, C. Csimma, H. Genant, A. Valentin‐Opran, Y. Amit, R. Arbel, H. Aro, D. Atar, M. Bishay, M. Börner, P. Chiron, P. Choong, J. Cinats, B. Courtenay, R. Feibel, B. Geulette, C. Gravel, N. Haas, M. Raschke, E. Hammacher, D. Velde, P. Hardy, M. Holt, C. Josten, R. Ketterl, B. Lindeque, G. Lob, H. Mathevon, G. McCoy, D. Marsh, Russell Miller, E. Munting, Stein Oevre, L. Nordsletten, Amratlal Patel, A. Pohl, W. Rennie, P. Reynders, P. Rommens, J. Rondia, Willem Rossouw, P. Daneel, S. Ruff, A. Rüter, S. Santavirta, T. Schildhauer, C. Gekle, R. Schnettler, D. Segal, Hanns Seiler, R. Snowdowne, J. Stapert, G. Taglang, R. Verdonk, L. Vogels, A. Weckbach, A. Wentzensen, T. Wisniewski (2002)
Recombinant Human Bone Morphogenetic Protein-2 for Treatment of Open Tibial Fractures: A Prospective, Controlled, Randomized Study of Four Hundred and Fifty PatientsThe Journal of Bone & Joint Surgery, 84
-
T. SampathS, James Maliakal, Peter, Hauschkatn, W. Jones, Halina Sasak, Ronald, Tucker, Kerry White, J. Coughlin, M. Tucker, H. Roy, Pang, Clare Corbett, E. Ozkaynak, H. Oppermann, D. Rueger (1992)
Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro.The Journal of biological chemistry, 267 28
-
M. Termaat, F. Boer, F. Bakker, P. Patka, H. Haarman (2005)
Bone morphogenetic proteins. Development and clinical efficacy in the treatment of fractures and bone defects.The Journal of bone and joint surgery. American volume, 87 6
-
R. Geesink, N. Hoefnagels, S. Bulstra (1999)
Osteogenic activity of OP-1 bone morphogenetic protein (BMP-7) in a human fibular defect.The Journal of bone and joint surgery. British volume, 81 4
-
E. Vögelin, N. Jones, Jerry Huang, J. Brekke, Jay Lieberman (2005)
Healing of a critical-sized defect in the rat femur with use of a vascularized periosteal flap, a biodegradable matrix, and bone morphogenetic protein.The Journal of bone and joint surgery. American volume, 87 6
-
C. Bramlage, T. Häupl, C. Kaps, P. Bramlage, G. Müller, F. Strutz (2005)
Bone Morphogenetic Proteins im Skelettsystem—Zeitschrift für Rheumatologie, 64
-
Michael Mont, P. Ragland, Bridget Biggins, G. Friedlaender, Tushar Patel, S. Cook, Gracia Etienne, A. Shimmin, Robyn Kildey, D. Rueger, T. Einhorn (2004)
Use of bone morphogenetic proteins for musculoskeletal applications. An overview.The Journal of bone and joint surgery. American volume, 86-A Suppl 2
-
P. Govender, Y. Rampersaud, Lynda Rickards, M. Fehlings (2002)
Use of osteogenic protein-1 in spinal fusion: literature review and preliminary results in a prospective series of high-risk cases.Neurosurgical focus, 13 6
-
G. Mundy (1996)
Regulation of bone formation by bone morphogenetic proteins and other growth factors.Clinical orthopaedics and related research, 324
-
R. Rothman, J. Klemek, J. Toton (1971)
The effect of iron deficiency anemia on fracture healing.Clinical orthopaedics and related research, 77
-
Mechrefe Mechrefe, Koh Koh, Trafton Trafton, DiGiovanni DiGiovanni (2006)
Tibial nonunionFoot Ankle Clin, 11
-
Q. Kang, Q. Kang, Sun Mh, Hongwei Cheng, Ying Peng, A. Montag, A. Deyrup, A. Deyrup, Wei Jiang, H. Luu, Jinyong Luo, J. Szatkowski, P. Vanichakarn, Jae Park, Y. Li, R. Haydon, T. He (2004)
Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene deliveryGene Therapy, 11
-
T. Einhorn (2003)
Clinical applications of recombinant human BMPs: early experience and future development.The Journal of bone and joint surgery. American volume, 85-A Suppl 3
-
Michael Kain, T. Einhorn (2005)
Recombinant human bone morphogenetic proteins in the treatment of fractures.Foot and ankle clinics, 10 4
-
P. Maniscalco, D. Gambera, C. Bertone, F. Rivera, E. Crainz, S. Urgelli (2002)
Healing of fresh tibial fractures with OP-1. A preliminary report.Acta bio-medica : Atenei Parmensis, 73 1-2
-
A. Poynton, J. Lane (2002)
Safety Profile for the Clinical Use of Bone Morphogenetic Proteins in the SpineSpine, 27
-
M. Pećina, L. Giltaij, S. Vukicevic (2001)
Orthopaedic applications of osteogenic protein-1 (BMP-7)International Orthopaedics, 25
-
A. Bergmann, B. Schwarz, H. Mittelmeier (1989)
[Cause, prognosis and therapy of tibial pseudarthroses].Aktuelle Traumatologie, 19 5
-
W. Lungershausen, F. Schulz (2000)
[Normal and impaired fracture healing].Zentralblatt fur Chirurgie, 125 9
-
C. Finkemeier, M. Chapman (2002)
Treatment of Femoral Diaphyseal NonunionsClinical Orthopaedics and Related Research, 1
-
Joseph Lane, E. Tomin, Mathias Bostrom (1999)
Biosynthetic bone grafting.Clinical orthopaedics and related research, 367 Suppl
-
A. Reddi (1997)
Bone morphogenetic proteins: an unconventional approach to isolation of first mammalian morphogens.Cytokine & growth factor reviews, 8 1
-
C. Gaebler, U. Berger, P. Schandelmaier, M. Greitbauer, H. Schauwecker, Brooks Applegate, G. Zych, Vilmos Vécsei (2001)
Rates and Odds Ratios for Complications in Closed and Open Tibial Fractures Treated With Unreamed, Small Diameter Tibial Nails: A Multicenter Analysis of 467 CasesJournal of Orthopaedic Trauma, 15
- Publisher
- Wiley
- Copyright
- Copyright © 2007 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 1445-1433
- eISSN
- 1445-2197
- DOI
- 10.1111/j.1445-2197.2007.04175.x
- pmid
- 17635273
- Publisher site
- See Article on Publisher Site
Abstract
The role of bone morphogenetic proteins (BMPs) in bone healing has been shown in numerous animal models. To date, at least 20 BMPs have been identified, some of which have been shown in vitro to stimulate the process of stem cell differentiation into osteoblasts in human and animal models. Having realized the osteoinductive properties of BMPs and having identified their genetic sequences, recombinant gene technology has been used to produce BMPs for clinical application – most commonly, as alternatives or adjuncts in the treatment of cases in which fracture healing is compromised. BMP‐2 and BMP‐7 are approved for clinical use in open fractures of long bones, non‐unions and spinal fusion. However, despite significant evidence of their potential benefit to bone repair and regeneration in animal and preclinical studies, there is, to date, a dearth of convincing clinical trials. The purpose of this paper is to give a brief overview of BMPs and to critically review the clinical data currently available on the use of BMP‐2 and BMP‐7 in fracture healing.
Journal
Anz Journal of Surgery – Wiley
Published: Aug 1, 2007