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The Role of Growth Factors in the Repair of Bone : Biology and Clinical Applications

The Role of Growth Factors in the Repair of Bone : Biology and Clinical Applications <h2>Introduction</h2> •: Growth factors (bone morphogenetic protein, transforming growth factor-beta, fibroblast growth factor, platelet-derived growth factor, and insulin-like growth factor) are proteins secreted by cells that act on the appropriate target cell or cells to carry out a specific action. •: Because growth factors are expressed during different phases of fracture-healing, it has been thought that they may serve as potential therapeutic agents to enhance bone repair. •: The selection of an appropriate carrier or delivery system for a particular growth factor is essential in order to induce a specific biologic effect. •: There are a number of potential clinical applications for growth factors in the enhancement of bone repair, including acceleration of fracture-healing, treatment of established nonunions, enhancement of primary spinal fusion or treatment of established pseudarthrosis of the spine, and as one element of a comprehensive tissue-engineering strategy that could include gene therapy to treat large bone-loss problems. Growth factors are proteins that serve as signaling agents for cells. They function as part of a vast cellular communications network that influences such critical functions as cell division, matrix synthesis, and tissue differentiation. The results of experimental studies have established that growth factors play an important role http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Bone and Joint Surgery Wolters Kluwer Health

The Role of Growth Factors in the Repair of Bone : Biology and Clinical Applications

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Publisher
Wolters Kluwer Health
Copyright
Copyright © 2002 by The Journal of Bone and Joint Surgery, Inc.
ISSN
0021-9355
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Abstract

<h2>Introduction</h2> •: Growth factors (bone morphogenetic protein, transforming growth factor-beta, fibroblast growth factor, platelet-derived growth factor, and insulin-like growth factor) are proteins secreted by cells that act on the appropriate target cell or cells to carry out a specific action. •: Because growth factors are expressed during different phases of fracture-healing, it has been thought that they may serve as potential therapeutic agents to enhance bone repair. •: The selection of an appropriate carrier or delivery system for a particular growth factor is essential in order to induce a specific biologic effect. •: There are a number of potential clinical applications for growth factors in the enhancement of bone repair, including acceleration of fracture-healing, treatment of established nonunions, enhancement of primary spinal fusion or treatment of established pseudarthrosis of the spine, and as one element of a comprehensive tissue-engineering strategy that could include gene therapy to treat large bone-loss problems. Growth factors are proteins that serve as signaling agents for cells. They function as part of a vast cellular communications network that influences such critical functions as cell division, matrix synthesis, and tissue differentiation. The results of experimental studies have established that growth factors play an important role

Journal

Journal of Bone and Joint Surgery – Wolters Kluwer Health

Published: Jun 1, 2002

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