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- Publisher
- Springer Journals
- Copyright
- Copyright © 2008 by Current Medicine Group LLC
- Subject
- Medicine & Public Health; Diagnostic Radiology; Interventional Radiology ; Imaging / Radiology
- ISSN
- 1522-6417
- eISSN
- 1534-3111
- DOI
- 10.1007/s11906-008-0029-7
- Publisher site
- See Article on Publisher Site
Abstract
The clustering of cardiovascular risk factors associated with abdominal obesity is well established. Although currently lacking a universal definition, the metabolic syndrome describes a constellation of metabolic abnormalities, including abdominal obesity, and was originally introduced to characterize a population at high cardiovascular risk. Adipose tissue is a dynamic endocrine organ that secretes several inflammatory and immune mediators known as adipokines. Dysregulation of adipokine secretion, free fatty acid toxicity, and the site-specific differences in abdominal (visceral) versus subcutaneous fat support abdominal obesity as a causal factor mediating the insulin resistance, increased risk of diabetes, and cardiovascular disease in the metabolic syndrome.
Journal
Current Hypertension Reports – Springer Journals
Published: Apr 27, 2008