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- Publisher
- Wiley
- Copyright
- Copyright © 2006 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 1930-7381
- eISSN
- 1930-739X
- DOI
- 10.1038/oby.2006.92
- pmid
- 16855188
- Publisher site
- See Article on Publisher Site
Abstract
Objective: Data from rodents provide evidence for a causal role of 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD‐1) in the development of obesity and its complications. In humans, 11β‐HSD‐1 is increased in subcutaneous adipose tissue (SAT) of obese patients, and higher adipose 11β‐HSD‐1 was associated with features of the metabolic syndrome. To date, there is no evidence for an increased expression of 11β‐HSD‐1 in human visceral adipose tissue (VAT), although VAT is the major predictor for insulin resistance and the metabolic syndrome.
Journal
Obesity – Wiley
Published: May 1, 2006
Keywords: ; ; ; ;