Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Effect of Algorithm-Based Therapy vs Usual Care on Clinical Success and Serious Adverse Events in Patients with Staphylococcal Bacteremia

Effect of Algorithm-Based Therapy vs Usual Care on Clinical Success and Serious Adverse Events in... Key PointsQuestionWhat is the effect of an algorithm used to define antibiotic choice and duration on clinical success and serious adverse events in patients with staphylococcal bacteremia? FindingsIn this randomized trial that included 509 adults with staphylococcal bacteremia, use of an algorithm compared with usual care resulted in a clinical success rate of 82.0% vs 81.5%, respectively, a difference that met the noninferiority margin of 15%. Serious adverse events occurred in 32.5% vs 28.3% of patients, a difference that was not statistically significant but with wide confidence intervals. MeaningThe use of an algorithm to guide testing and treatment compared with usual care resulted in a noninferior rate of clinical success; although there was not a significant difference in serious adverse events, interpretation is limited by wide confidence intervals. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Effect of Algorithm-Based Therapy vs Usual Care on Clinical Success and Serious Adverse Events in Patients with Staphylococcal Bacteremia

Download PDF
150 pages

Loading next page...
 
/lp/american-medical-association/effect-of-algorithm-based-therapy-vs-usual-care-on-clinical-success-6tYOzv9Grm

References (55)

Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2018.13155
pmid
30264119
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionWhat is the effect of an algorithm used to define antibiotic choice and duration on clinical success and serious adverse events in patients with staphylococcal bacteremia? FindingsIn this randomized trial that included 509 adults with staphylococcal bacteremia, use of an algorithm compared with usual care resulted in a clinical success rate of 82.0% vs 81.5%, respectively, a difference that met the noninferiority margin of 15%. Serious adverse events occurred in 32.5% vs 28.3% of patients, a difference that was not statistically significant but with wide confidence intervals. MeaningThe use of an algorithm to guide testing and treatment compared with usual care resulted in a noninferior rate of clinical success; although there was not a significant difference in serious adverse events, interpretation is limited by wide confidence intervals.

Journal

JAMA – American Medical Association

Published: Sep 25, 2018

There are no references for this article.