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- Publisher
- Springer Journals
- Copyright
- Copyright
- Subject
- Medicine & Public Health; Pharmacotherapy; Pharmacology/Toxicology; Internal Medicine
- ISSN
- 0312-5963
- eISSN
- 1179-1926
- DOI
- 10.2165/00003088-198207040-00004
- Publisher site
- See Article on Publisher Site
Abstract
The degree of binding to plasma proteins is an important determinant of drug disposition and response. Normal human pregnancy is associated with considerable changes in the concentration of plasma proteins, free fatty acids and possibly other endogenous substances interfering with drug binding. The possibility of an associated change in plasma binding capacity therefore needs to be taken into consideration.
Journal
Clinical Pharmacokinetics – Springer Journals
Published: Dec 13, 2012