Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/wiley/distribution-of-salicylate-between-neonatal-and-maternal-serum-at-yQH95LPcNZ
References (17)
-
A. Gornall, C. Bardawill, M. David (1949)
Determination of serum proteins by means of the biuret reaction.The Journal of biological chemistry, 177 2
-
(1973)
Pharmacokinetic aspects of placental drug transfer -
(1966)
Serum o-fetoprotein, albumin, and yg-globulin in the human conceptus,1 -
(1973)
Pharmacokinetic aspects of placental drug transfer, in Boreus, L., editor: Fetal pharmacology -
(1944)
The determination of sa1icylic acid in plasma -
J. Crawford, H. Hooi (1968)
Binding of salicylic acid and sulphanilamide in serum from pregnant patients, cord blood and subjects taking oral contraceptives.British journal of anaesthesia, 40 11
-
(1949)
Serum o-fetoprotein, albumin, and yg-globulin in the human conceptus -
A. Weinberg, G. Shapiro, D. Bruhn (1963)
ISOTOPIC PLACENTOGRAPHY. AN EVALUATION OF ITS ACCURACY AND SAFETY.American journal of obstetrics and gynecology, 87
-
G. Tucker, R. Boyes, Phillip Bridenbough, D. Moore (1970)
Binding of Anilide‐type Local Anesthetics in Human Plasma: II. Implications In Vivo, with Special Reference to Transplacental DistributionAnesthesiology, 33
-
L. Garrettson, J. Procknal, G. Levy (1975)
Fetal acquisition and neonatal elimination of a large amount of salicylateClinical Pharmacology & Therapeutics, 17
-
G. Steel (1968)
Principles and Practice of Obstetric Analgesia and AnesthesiaJournal of the Royal Society of Medicine, 61
-
(1972)
Plazentapassage von Natriumsalizylat , Zen - tralbl -
J. Dancis, N. Braverman, J. Lind (1957)
Plasma protein synthesis in the human fetus and placenta.The Journal of clinical investigation, 36 3
-
W. Hitzig (1963)
Die Plasmaproteine in der Klinischen Medizin -
P. Reboud, J. Groulade, P. Groslambert, M. Colomb (1963)
The influence of normal pregnancy and the postpartum state on plasma proteins and lipids.American journal of obstetrics and gynecology, 86
-
W. TEbood (1974)
The distribution of immunoglobulins and albumin between maternal and cord serum at delivery.The Journal of obstetrics and gynaecology of the British Commonwealth, 81 12
-
I. Bobok, G. Csako, H. Csernyånszky, K. Ludmány (1974)
Lipoids in maternal, cord and newborn blood serum.Acta paediatrica Academiae Scientiarum Hungaricae, 15 2
- Publisher
- Wiley
- Copyright
- © American Society for Clinical Pharmacology and Therapeutic
- ISSN
- 0009-9236
- eISSN
- 1532-6535
- DOI
- 10.1002/cpt1975182210
- Publisher site
- See Article on Publisher Site
Abstract
The post‐distributive neonatal: maternal plasma salicylate concentration ratio following salicylate administration to the mother before delivery is appreciably higher than unity. The protein binding of salicylate and the albumin concentration in one such plasma pair were considerably higher in the neonatal than in the maternal plasma. Equilibrium dialysis of neonatal plasma or serum from 6 newborn infants against that of their mothers produced a neonatal: maternal salicylate concentration ratio above unity in alt cases even if the albumin concentration in the neonatal serum did not exceed that in the maternal serum. However, there was a strong correlation between the neonatal: maternal concentration ratios of salicylate and albumin. These observations demonstrate that conclusions concerning the distribution of a drug across the placenta in relation to its plasma protein binding characteristics must be based on the results of binding studies witti plasma or serum from neonates and their mothers, and not from other adult subjects.
Journal
Clinical Pharmacology & Therapeutics – Wiley
Published: Aug 1, 1975