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Peaunut Agglutinin. A useful marker for histiocytosis x and interdigitating reticulum cells

Peaunut Agglutinin. A useful marker for histiocytosis x and interdigitating reticulum cells We studied the peanut agglutinin (PNA) staining patterns of histiocytosis X (H‐X) (three cases, including one case of Letterer‐Siwe disease) and well‐characterized cases of malignant histiocytosis (two cases) and monoblastic leukemia (one case) in paraffin‐embedded specimens. H‐X cells showed staining identical to that of interdigitating reticulum cells, with unique paranuclear and cell surface deposits of reaction products. Thus, H‐X cells were easily distinguished from benign macrophage‐histiocytes, which show diffuse cytoplasmic staining, and malignant cells of malignant histiocytosis and monoblastic leukemia, which did not stain with PNA. PNA staining proved more useful than Leu‐M1 antibody for this purpose, since neither interdigitating reticulum cells in ten reactive lymph nodes nor Langerhans' ‐type cells in three cases of H‐X were stained with Leu‐M1 antibody. These observations support a close relationship between H‐X cells and interdigitating reticulum cells, and demonstrate the usefulness of PNA for the identification of these cells in paraffin‐embedded material. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Wiley

Peaunut Agglutinin. A useful marker for histiocytosis x and interdigitating reticulum cells

Ree, H. J.; Kadin, Marshall E.
Cancer , Volume 57 (2) – Jan 15, 1986
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References (31)

Publisher
Wiley
Copyright
Copyright © 1986 American Cancer Society
ISSN
0008-543X
eISSN
1097-0142
DOI
10.1002/1097-0142(19860115)57:2<282::AID-CNCR2820570216>3.0.CO;2-Q
Publisher site
See Article on Publisher Site

Abstract

We studied the peanut agglutinin (PNA) staining patterns of histiocytosis X (H‐X) (three cases, including one case of Letterer‐Siwe disease) and well‐characterized cases of malignant histiocytosis (two cases) and monoblastic leukemia (one case) in paraffin‐embedded specimens. H‐X cells showed staining identical to that of interdigitating reticulum cells, with unique paranuclear and cell surface deposits of reaction products. Thus, H‐X cells were easily distinguished from benign macrophage‐histiocytes, which show diffuse cytoplasmic staining, and malignant cells of malignant histiocytosis and monoblastic leukemia, which did not stain with PNA. PNA staining proved more useful than Leu‐M1 antibody for this purpose, since neither interdigitating reticulum cells in ten reactive lymph nodes nor Langerhans' ‐type cells in three cases of H‐X were stained with Leu‐M1 antibody. These observations support a close relationship between H‐X cells and interdigitating reticulum cells, and demonstrate the usefulness of PNA for the identification of these cells in paraffin‐embedded material.

Journal

Cancer – Wiley

Published: Jan 15, 1986

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