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Unusual Histiocytic Reaction to Lymph Nodes in Letterer-Siwe Disease

Unusual Histiocytic Reaction to Lymph Nodes in Letterer-Siwe Disease UNUSUAL HISTIOCYTIC REACTION TO LYMPH NODES I N LETTERER-SIWE DISEASE* N. G. B. McLETCHIE, M.D . The Institute of Pathology ofDalhousie University and the Government of Nova Scotia, Halifax, Nova Scotia This communication is prompted by the examination of lymph nodes in a case of Letterer-Siwe disease. The patient was a youth who reported to his doctor with a skin rash. Within 2 weeks he had generalized lymphadenopathy and severe toxemia and went rapidly downhill. The lymph-node pathology was clearly defined; the reacting cells were histiocytes and the morbid reaction was strictly sinus in origin. There were, however, some conspicuous features in the node hitherto not described, and in studying the literature some confusing issues were encountered. I t is proposed to describe the pathology of the lymph nodes in detail, and in the discourse to attempt to steer a rational path through the relevant literature. HISTORY OF CASE A 14-year-old male student was admitted to the hospital on September 26, 1950, com­ plaining of "swelling of glands." The history began about SerjtembfiJ^J_,_125_G'> when he developed a red, pimply, nonitchy skin eruption on th e chest, abdomen, inner aspects of th e thighs and along the hairline of the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Clinical Pathology Oxford University Press

Unusual Histiocytic Reaction to Lymph Nodes in Letterer-Siwe Disease

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Publisher
Oxford University Press
Copyright
© American Society of Clinical Pathologists
ISSN
0002-9173
eISSN
1943-7722
DOI
10.1093/ajcp/22.6.520
Publisher site
See Article on Publisher Site

Abstract

UNUSUAL HISTIOCYTIC REACTION TO LYMPH NODES I N LETTERER-SIWE DISEASE* N. G. B. McLETCHIE, M.D . The Institute of Pathology ofDalhousie University and the Government of Nova Scotia, Halifax, Nova Scotia This communication is prompted by the examination of lymph nodes in a case of Letterer-Siwe disease. The patient was a youth who reported to his doctor with a skin rash. Within 2 weeks he had generalized lymphadenopathy and severe toxemia and went rapidly downhill. The lymph-node pathology was clearly defined; the reacting cells were histiocytes and the morbid reaction was strictly sinus in origin. There were, however, some conspicuous features in the node hitherto not described, and in studying the literature some confusing issues were encountered. I t is proposed to describe the pathology of the lymph nodes in detail, and in the discourse to attempt to steer a rational path through the relevant literature. HISTORY OF CASE A 14-year-old male student was admitted to the hospital on September 26, 1950, com­ plaining of "swelling of glands." The history began about SerjtembfiJ^J_,_125_G'> when he developed a red, pimply, nonitchy skin eruption on th e chest, abdomen, inner aspects of th e thighs and along the hairline of the

Journal

American Journal of Clinical Pathology – Oxford University Press

Published: Jun 1, 1952

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