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do they really go together like a horse and carriage? J
- Publisher
- Springer Journals
- Copyright
- Copyright © 2007 by Nature Publishing Group
- Subject
- Biomedicine; Biomedicine, general; Immunology; Infectious Diseases
- ISSN
- 1529-2908
- eISSN
- 1529-2916
- DOI
- 10.1038/ni1446
- Publisher site
- See Article on Publisher Site
Abstract
The molecular basis underlying the specificity of alloreactive T cells for peptide–major histocompatibility complex ligands has been elusive. Here we describe a screen of 60 I-Ek-alloreactive T cells and 83 naturally processed peptides that identified 9 reactive T cells. Three of the T cells responded to multiple, distinct peptides that shared no sequence homology. These T cells recognized each peptide–major histocompatibility complex ligand specifically and used a distinct constellation of I-Ek contact residues for each interaction. Our studies show that alloreactive T cells have a 'germline-encoded' capacity to recognize multiple, distinct ligands and thus show 'polyspecificity', not degeneracy. Our findings help to explain the high frequency of alloreactive T cells and provide insight into the nature of T cell specificity.
Journal
Nature Immunology – Springer Journals
Published: Feb 25, 2007