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H. Zeng, Guosheng Liu, P. Rea, G. Kruh (2000)
Transport of amphipathic anions by human multidrug resistance protein 3.Cancer research, 60 17
S. Colowick, M. Joshi, Jagannathan, N. Kaplan (1966)
Methods in Enzymology , Vol
R. Evers, Marcel Kool, L. Deemter, H. Janssen, J. Calafat, L. Oomen, C. Paulusma, R. Elferink, F. Baas, A. Schinkel, P. Borst (1998)
Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.The Journal of clinical investigation, 101 7
K. Berge, H. Tian, G. Graf, Liqing Yu, N. Grishin, J. Schultz, P. Kwiterovich, Bei Shan, R. Barnes, H. Hobbs (2000)
Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters.Science, 290 5497
A. Schinkel, Stephan Kemp, Martijn Dollé, Gabrielle Rudenko, E. Wagenaar (1993)
N-glycosylation and deletion mutants of the human MDR1 P-glycoprotein.The Journal of biological chemistry, 268 10
E. Choo, B. Leake, C. Wandel, H. Imamura, A. Wood, G. Wilkinson, R. Kim (2000)
Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes.Drug metabolism and disposition: the biological fate of chemicals, 28 6
É. Bakos, Raymond Evers, Emese Sinkó, A. Váradi, Piet Borst, Balázs Sarkadi (2000)
Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions.Molecular pharmacology, 57 4
R. Robey, Wilma Medina-Pérez, K. Nishiyama, T. Lahusen, K. Miyake, T. Litman, A. Senderowicz, Douglas Ross, S. Bates (2001)
Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells.Clinical cancer research : an official journal of the American Association for Cancer Research, 7 1
Wijnholds (2000)
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogsProc. Natl. Acad. Sci. USA, 97
Chen (2001)
Transport of cyclic nucleotides and estradiol 17-?-d-glucuronide by multidrug resistance protein 4J. Biol. Chem., 276
D. Loe, K. Almquist, R. Deeley, S. Cole (1996)
Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport.The Journal of biological chemistry, 271 16
S. Kala, M. Neely, G. Kala, Christopher Prater, Donna Atwood, J. Rice, M. Lieberman (2000)
The MRP2/cMOAT Transporter and Arsenic-Glutathione Complex Formation Are Required for Biliary Excretion of Arsenic*The Journal of Biological Chemistry, 275
U. Mayer, E. Wagenaar, B. Dorobek, J. Beijnen, P. Borst, A. Schinkel (1997)
Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833.The Journal of clinical investigation, 100 10
Raimundus Aubel, M. Kuijck, J. Koenderink, P. Deen, C. Os, F. Russel (1998)
Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein Mrp2 expressed in insect cells.Molecular pharmacology, 53 6
Zhe-Sheng Chen, Kun Lee, G. Kruh (2001)
Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine.The Journal of biological chemistry, 276 36
A. Loevezijn, J. Allen, A. Schinkel, G. Koomen (2001)
Inhibition of BCRP-mediated drug efflux by fumitremorgin-type indolyl diketopiperazines.Bioorganic & medicinal chemistry letters, 11 1
Yi Chen, L. Mickley, Arnold Schwartz, E. Acton, Jaulang Hwang, A. Fojo (1990)
Characterization of adriamycin-resistant human breast cancer cells which display overexpression of a novel resistance-related membrane protein.The Journal of biological chemistry, 265 17
A. Schinkel, J. Smit, O. Tellingen, J. Beijnen, E. Wagenaar, L. Deemter, C. Mol, M. Valk, E. Robanus-Maandag, H. Riele, A. Berns, P. Borst (1994)
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugsCell, 77
M. Malingré, J. Beijnen, H. Rosing, F. Koopman, R. Jewell, E. Paul, W. Huinink, J. Schellens (2001)
Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patientsBritish Journal of Cancer, 84
T. Hirohashi, H. Suzuki, Kousei Ito, K. Ogawa, K. Kume, T. Shimizu, Y. Sugiyama (1998)
Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats.Molecular pharmacology, 53 6
J. Hooijberg, H. Broxterman, Marcel Kool, Y. Assaraf, G. Peters, P. Noordhuis, R. Scheper, P. Borst, H. Pinedo, G. Jansen (1999)
Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.Cancer research, 59 11
T. Litman, T. Druley, W. Stein, S. Bates (2001)
From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significanceCellular and Molecular Life Sciences CMLS, 58
Kool (1999)
MRP3, an organic anion transporter able to transport anti-cancer drugsProc. Natl. Acad. Sci. USA, 96
R. Evers, G. Zaman, L. Deemter, H. Jansen, J. Calafat, L. Oomen, R. Elferink, P. Borst, A. Schinkel (1996)
Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells.The Journal of clinical investigation, 97 5
E. Volk, Kristin Rohde, M. Rhee, J. McGuire, L. Doyle, Douglas Ross, E. Schneider (2000)
Methotrexate cross-resistance in a mitoxantrone-selected multidrug-resistant MCF7 breast cancer cell line is attributable to enhanced energy-dependent drug efflux.Cancer research, 60 13
Marcel Kool, M. Haasde, G. Scheffer, R. Scheper, T. EijkvanM.J., J. Juijn, F. Baas, P. Borst (1997)
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.Cancer research, 57 16
Meerum Terwogt (1998)
Increased systemic exposure to oral paclitaxel in cancer patients treated with cyclosporin ALancet, 352
C. Scharenberg, M. Harkey, B. Torok-Storb (2002)
The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors.Blood, 99 2
J. Polli, J. Jarrett, S. Studenberg, J. Humphreys, Steven Dennis, K. Brouwer, J. Woolley (1999)
Role of P-Glycoprotein on the CNS Disposition of Amprenavir (141W94), an HIV Protease InhibitorPharmaceutical Research, 16
U. Mayer, E. Wagenaar, J. Beijnen, J. Smit, D. Meijer, J. Asperen, P. Borst, A. Schinkel (1996)
Substantial excretion of digoxin via the intestinal mucosa and prevention of long‐term digoxin accumulation in the brain by the mdrla P‐glycoproteinBritish Journal of Pharmacology, 119
C. Paulusma, P. Bosma, G. Zaman, C. Bakker, M. Otter, G. Scheffer, R. Scheper, P. Borst, R. Elferink (1996)
Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein GeneScience, 271
J. Terwogt, J. Beijnen, W. Huinink, H. Rosing, J. Schellens (1998)
Co-administration of cyclosporin enables oral therapy with paclitaxelThe Lancet, 352
Wijnholds (1997)
Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking MRPNature Med., 3
J. Smit, A. Schinkel, B. Weert, D. Meijer (1998)
Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disruptedBritish Journal of Pharmacology, 124
S. Rabindran, Douglas Ross, L. Doyle, Weidong Yang, L. Greenberger (2000)
Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein.Cancer research, 60 1
S. Cole, K. Sparks, K. Fraser, D. Loe, C. Grant, G. Wilson, R. Deeley (1994)
Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells.Cancer research, 54 22
V. Fischer, A. Rodríguez-Gascón, F. Heitz, R. Tynes, C. Hauck, D. Cohen, A. Vickers (1998)
The multidrug resistance modulator valspodar (PSC 833) is metabolized by human cytochrome P450 3A. Implications for drug-drug interactions and pharmacological activity of the main metabolite.Drug metabolism and disposition: the biological fate of chemicals, 26 8
D. Loe, R. Deeley, S. Cole (1998)
Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione.Cancer research, 58 22
J. Allen, R. Brinkhuis, L. Deemter, J. Wijnholds, A. Schinkel (2000)
Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance.Cancer research, 60 20
Yunhai Cui, J. König, U. Buchholz, Herbert Spring, I. Leier, D. Keppler (1999)
Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells.Molecular pharmacology, 55 5
Maliepaard (2001)
Subcellular localization and distribution of the breast cancer resistance protein in normal human tissuesCancer Res., 61
G. Scheffer, M. Maliepaard, A. Pijnenborg, M. Gastelen, M. Jong, A. Schroeijers, D. Kolk, J. Allen, Douglas Ross, P. Valk, W. Dalton, J. Schellens, R. Scheper (2000)
Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines.Cancer research, 60 10
A. Shapiro, Kelly Fox, P. Lam, V. Ling (2001)
Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site.European journal of biochemistry, 259 3
T. Knutsen, V. Rao, T. Ried, L. Mickley, E. Schneider, K. Miyake, B. Ghadimi, H. Padilla-Nash, S. Pack, L. Greenberger, K. Cowan, M. Dean, T. Fojo, Susan Bates (2000)
Amplification of 4q21–q22 and the MXR gene in independently derived mitoxantrone‐resistant cell linesGenes, 27
D. Keppler, I. Leier, G. Jedlitschky, J. König (1998)
ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2.Chemico-biological interactions, 111-112
J. Smit, M. Huisman, O. Tellingen, H. Wiltshire, A. Schinkel (1999)
Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure.The Journal of clinical investigation, 104 10
J. Wijnholds, C. Mol, L. Deemter, M. Haas, G. Scheffer, F. Baas, J. Beijnen, R. Scheper, S. Hatse, E. Clercq, J. Balzarini, P. Borst (2000)
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs.Proceedings of the National Academy of Sciences of the United States of America, 97 13
L. Breuninger, S. Paul, Kathleen Gaughan, T. Miki, A. Chan, Stuart Aaronson, G. Kruh (1995)
Expression of multidrug resistance-associated protein in NIH/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution.Cancer research, 55 22
Masayuki Masuda, Yuji I'izuka, M. Yamazaki, R. Nishigaki, Y. Kato, K. Niinuma, H. Suzuki, Y. Sugiyama (1997)
Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats.Cancer research, 57 16
Jong Lee, S. Scala, Y. Matsumoto, B. Dickstein, R. Robey, Z. Zhan, G. Altenberg, S. Bates (1997)
Reduced drug accumulation and multidrug resistance in human breast cancer cells without associated P‐glycoprotein or MRP overexpressionJournal of Cellular Biochemistry, 65
N. Hendrikse, A. Schinkel, E. Vries, E. Fluks, W. Graaf, A. Willemsen, W. Vaalburg, E. Franssen (1998)
Complete in vivo reversal of P‐glycoprotein pump function in the blood‐brain barrier visualized with positron emission tomographyBritish Journal of Pharmacology, 124
C. Cordon-Cardo, J. O'brien, Dolors Casals, Lana Rittman-Grauer, J. Biedler, M. Melamed, J. Bertino (1989)
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.Proceedings of the National Academy of Sciences of the United States of America, 86 2
Fischer (1998)
The multidrug resistance modulator valspodar (PSC 833) is metabolized by human cytochrome P450 3ADrug Met. Disp., 26
Gary Ewart, Anthony Howells (1998)
ABC transporters involved in transport of eye pigment precursors in Drosophila melanogaster.Methods in enzymology, 292
J. Wijnholds, E. Lange, G. Scheffer, D. Berg, C. Mol, M. Valk, A. Schinkel, R. Scheper, D. Breimer, P. Borst (2000)
Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier.The Journal of clinical investigation, 105 3
C. Dietrich, D. Waart, R. Ottenhoff, I. Schoots, R. Elferink (2001)
Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-deficient rats.Molecular pharmacology, 59 5
A. Mottino, T. Hoffman, L. Jennes, M. Vore (2000)
Expression and localization of multidrug resistant protein mrp2 in rat small intestine.The Journal of pharmacology and experimental therapeutics, 293 3
D. Hipfner, R. Deeley, S. Cole (1999)
Structural, mechanistic and clinical aspects of MRP1.Biochimica et biophysica acta, 1461 2
Alexander Smith, Johanna Timmermans-Hereijgers, B. Roelofsen, K. Wirtz, W. Blitterswijk, J. Smit, A. Schinkel, P. Borst (1994)
The human MDR3 P‐glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic miceFEBS Letters, 354
Jan Taipalensuu, H. Törnblom, G. Lindberg, C. Einarsson, F. Sjöqvist, H. Melhus, P. Garberg, B. Sjöström, B. Lundgren, P. Artursson (2001)
Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers.The Journal of pharmacology and experimental therapeutics, 299 1
J. König, A. Nies, Yunhai Cui, I. Leier, D. Keppler (1999)
Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance.Biochimica et biophysica acta, 1461 2
R. Aubel, P. Smeets, J. Peters, R. Bindels, F. Russel (2002)
The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP.Journal of the American Society of Nephrology : JASN, 13 3
D. Rost, J. König, G. Weiss, E. Klar, W. Stremmel, D. Keppler (2001)
Expression and localization of the multidrug resistance proteins MRP2 and MRP3 in human gallbladder epithelia.Gastroenterology, 121 5
Kumie Kage, Satomi Tsukahara, T. Sugiyama, Sakiyo Asada, E. Ishikawa, T. Tsuruo, Y. Sugimoto (2002)
Dominant‐negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S‐S dependent homodimerizationInternational Journal of Cancer, 97
R. Allikmets, L. Schriml, A. Hutchinson, V. Romano-Spica, Michael Dean (1998)
A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance.Cancer research, 58 23
Soignet (1998)
Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxideNew Engl. J. Med., 339
M. Huisman, J. Smit, A. Schinkel (2000)
Significance of P-glycoprotein for the pharmacology and clinical use of HIV protease inhibitorsAIDS, 14
van Loevezijn (2001)
Inhibition of BCRP-mediated drug efflux by fumitremorgin-type indolyl diketopiperazinesBiorgan. Med. Chem. Lett., 11
I. Leier, G. Jedlitschky, U. Buchholz, S. Cole, R. Deeley, D. Keppler (1994)
The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.The Journal of biological chemistry, 269 45
T. Schaub, J. Kartenbeck, J. König, Herbert Spring, J. Dörsam, G. Staehler, Stephan ST̈ORKEL, W. Thon, D. Keppler (1999)
Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal cell carcinoma.Journal of the American Society of Nephrology : JASN, 10 6
M. Huisman, J. Smit, H. Wiltshire, R. Hoetelmans, J. Beijnen, A. Schinkel (2001)
P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir.Molecular pharmacology, 59 4
A. Schinkel (1997)
The physiological function of drug-transporting P-glycoproteins.Seminars in cancer biology, 8 3
R. Elferink, D. Meijer, F. Kuipers, Peter Jansen, A. Groen, G. Groothuis (1995)
Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport.Biochimica et biophysica acta, 1241 2
R. Robey, Yasumasa Honjo, A. Laar, Keisuke Miyake, Joanna Regis, Thomas Litman, Susan Bates (2001)
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).Biochimica et biophysica acta, 1512 2
Z. Holló, L. Homolya, Tamás Hegedüs, B. Sarkadi (1996)
Transport properties of the multidrug resistance‐associated protein (MRP) in human tumour cellsFEBS Letters, 383
A. Dantzig, R. Shepard, Jin Cao, K. Law, W. Ehlhardt, T. Baughman, T. Bumol, J. Starling (1996)
Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979.Cancer research, 56 18
Csilla Özvegy, T. Litman, G. Szakács, Z. Nagy, S. Bates, A. Váradi, B. Sarkadi (2001)
Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells.Biochemical and biophysical research communications, 285 1
R. Kondratov, P. Komarov, Yigal Becker, A. Ewenson, A. Gudkov (2001)
Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoproteinProceedings of the National Academy of Sciences of the United States of America, 98
Keppler (1998)
ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2Chem. Biol. Interact., 111–112
T. Saito, Z. Zhang, T. Ohtsubo, I. Noda, Y. Shibamori, T. Yamamoto, H. Saito (2001)
Homozygous disruption of the mdrla P-glycoprotein gene affects blood-nerve barrier function in mice administered with neurotoxic drugs.Acta oto-laryngologica, 121 6
A. Schinkel (1999)
P-Glycoprotein, a gatekeeper in the blood-brain barrier.Advanced drug delivery reviews, 36 2-3
Marcel Kool, M. Linden, M. Haas, G. Scheffer, J. Vree, Alexander Smith, G. Jansen, G. Peters, N. Ponne, R. Scheper, R. Elferink, F. Baas, P. Borst (1999)
MRP3, an organic anion transporter able to transport anti-cancer drugs.Proceedings of the National Academy of Sciences of the United States of America, 96 12
B. Sikic (1999)
Modulation of multidrug resistance: a paradigm for translational clinical research.Oncology, 13 5A
C. Kruijtzer, J. Beijnen, H. Rosing, W. Huinink, M. Schot, R. Jewell, E. Paul, J. Schellens (2002)
Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 20 13
M. Büchler, J. König, M. Brom, J. Kartenbeck, Herbert Spring, T. Horie, D. Keppler (1996)
cDNA Cloning of the Hepatocyte Canalicular Isoform of the Multidrug Resistance Protein, cMrp, Reveals a Novel Conjugate Export Pump Deficient in Hyperbilirubinemic Mutant Rats*The Journal of Biological Chemistry, 271
P. Borst, R. Evers, Marcel Kool, J. Wijnholds (2000)
A family of drug transporters: the multidrug resistance-associated proteins.Journal of the National Cancer Institute, 92 16
A. Schinkel, E. Wagenaar, L. Deemter, C. Mol, P. Borst (1995)
Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.The Journal of clinical investigation, 96 4
Zaman (1995)
Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated proteinProc. Natl. Acad. Sci. USA, 92
Kondratov (2001)
Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoproteinProc. Natl. Acad. Sci. USA, 98
C. Erlichman, S. Boerner, C. Hallgren, Rebecca Spieker, X. Wang, C. James, G. Scheffer, M. Maliepaard, Douglas Ross, K. Bible, S. Kaufmann (2001)
The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux.Cancer research, 61 2
D. Keppler, J. König (2000)
Hepatic Secretion of Conjugated Drugs and Endogenous SubstancesSEMINARS IN LIVER DISEASE, Volume 20
R. Mayer, Jiirgen Kartenbeck, M. Biichler, G. Jedlitschky, I. Leier, D. Keppler, D. Keppler (1995)
Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport- deficient mutant hepatocytesThe Journal of Cell Biology, 131
D. Loe, K. Almquist, S. Cole, R. Deeley (1996)
ATP-dependent 17-Estradiol 17-(-D-Glucuronide) Transport by Multidrug Resistance Protein (MRP)The Journal of Biological Chemistry, 271
Da-Wei Zhang, S. Cole, R. Deeley (2001)
Identification of a Nonconserved Amino Acid Residue in Multidrug Resistance Protein 1 Important for Determining Substrate SpecificityThe Journal of Biological Chemistry, 276
C. Dietrich, D. Waart, R. Ottenhoff, A. Bootsma, A. Gennip, R. Elferink (2001)
Mrp2-deficiency in the rat impairs biliary and intestinal excretion and influences metabolism and disposition of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo.Carcinogenesis, 22 5
T. Tsuruo, H. Iida, S. Tsukagoshi, Y. Sakurai (1981)
Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.Cancer research, 41 5
A. Helvoort, Alexander Smith, H. Sprong, I. Fritzsche, A. Schinkel, P. Borst, G. Meer (1996)
MDR1 P-Glycoprotein Is a Lipid Translocase of Broad Specificity, While MDR3 P-Glycoprotein Specifically Translocates PhosphatidylcholineCell, 87
Dennis Johnson, R. Finch, Z. Lin, Caroline Zeiss, Alan Sartorelli (2001)
The pharmacological phenotype of combined multidrug-resistance mdr1a/1b- and mrp1-deficient mice.Cancer research, 61 4
Sparreboom (1997)
Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestineProc. Natl. Acad. Sci. USA, 94
E. Rocchi, Alexey Khodjakov, A. Khodjakov, E. Volk, E. Volk, Chih‐Hsin Yang, T. Litman, S. Bates, E. Schneider, E. Schneider (2000)
The product of the ABC half-transporter gene ABCG2 (BCRP/MXR/ABCP) is expressed in the plasma membrane.Biochemical and biophysical research communications, 271 1
J. Wijnholds, G. Scheffer, Martin Valk, Paul Valk, J. Beijnen, R. Scheper, P. Borst (1998)
Multidrug Resistance Protein 1 Protects the Oropharyngeal Mucosal Layer and the Testicular Tubules against Drug-induced DamageThe Journal of Experimental Medicine, 188
Fran, ois Hyafil, C. Vergely, Pierre Vignaud, T. Grand‐Perret (1993)
In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative.Cancer research, 53 19
E. Leslie, Ken-ich Ito, P. Upadhyaya, S. Hecht, R. Deeley, S. Cole (2001)
Transport of the β-O-Glucuronide Conjugate of the Tobacco-specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the Multidrug Resistance Protein 1 (MRP1)The Journal of Biological Chemistry, 276
S. Rabindran, Hai-yin He, Maya Singh, Eileen Brown, Karen Collins, T. Annable, L. Greenberger (1998)
Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C.Cancer research, 58 24
Kun Lee, M. Belinsky, D. Bell, J. Testa, G. Kruh (1998)
Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter.Cancer research, 58 13
Yasumasa Honjo, C. Hrycyna, Qing-Wu Yan, Wilma Medina-Pérez, R. Robey, A. Laar, T. Litman, Michael Dean, S. Bates (2001)
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.Cancer research, 61 18
R. Juliano, V. Ling, V. Ling (1976)
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants.Biochimica et biophysica acta, 455 1
S. Cole, G. Bhardwaj, J. Gerlach, J. Mackie, C. Grant, K. Almquist, A. Stewart, E. Kurz, A. Duncan, R. Deeley (1992)
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line.Science, 258 5088
F. Thiébaut, T. Tsuruo, H. Hamada, M. Gottesman, I. Pastan, M. Willingham (1987)
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.Proceedings of the National Academy of Sciences of the United States of America, 84 21
A. Senior, D. Gadsby (1997)
ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR.Seminars in cancer biology, 8 3
L. Hazlehurst, Nils Foley, M. Gleason-Guzman, M. Hacker, A. Cress, L. Greenberger, M. Jong, W. Dalton (1999)
Multiple mechanisms confer drug resistance to mitoxantrone in the human 8226 myeloma cell line.Cancer research, 59 5
Doyle (1998)
A multidrug resistance transporter from human MCF-7 breast cancer cellsProc. Natl. Acad. Sci. USA, 95
D. Boesch, C. Gavériaux, B. Jachez, A. Pourtier-Manzanedo, P. Bollinger, F. Loor (1991)
In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833.Cancer research, 51 16
D. Robbiani, R. Finch, D. Jäger, W. Muller, A. Sartorelli, G. Randolph (2000)
The Leukotriene C4 Transporter MRP1 Regulates CCL19 (MIP-3β, ELC)–Dependent Mobilization of Dendritic Cells to Lymph NodesCell, 103
R. Aubel, A. Hartog, R. Bindels, C. Os, F. Russel (2000)
Expression and immunolocalization of multidrug resistance protein 2 in rabbit small intestine.European journal of pharmacology, 400 2-3
C. Panwala, Jon Jones, J. Viney (1998)
A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis.Journal of immunology, 161 10
T. Hirohashi, H. Suzuki, H. Takikawa, Yuichi Sugiyama (2000)
ATP-dependent Transport of Bile Salts by Rat Multidrug Resistance-associated Protein 3 (Mrp3)*The Journal of Biological Chemistry, 275
M. Maliepaard, M. Gastelen, Laurina Jong, D. Pluim, R. Waardenburg, M. Ruevekamp‐Helmers, B. Floot, J. Schellens (1999)
Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line.Cancer research, 59 18
T. Cantz, A. Nies, M. Brom, A. Hofmann, D. Keppler (2000)
MRP2, a human conjugate export pump, is present and transports fluo 3 into apical vacuoles of Hep G2 cells.American journal of physiology. Gastrointestinal and liver physiology, 278 4
J. Schuetz, M. Connelly, Daxi Sun, S. Paibir, P. Flynn, R. Srinivas, Alok Kumar, A. Fridland (1999)
MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugsNature Medicine, 5
G. Kruh, Andrew Chan, Kim Myers, Kathleen Gaughan, Toru Miki, Stuart Aaronson (1994)
Expression complementary DNA library transfer establishes mrp as a multidrug resistance gene.Cancer research, 54 7
G. Zaman, J. Lankelma, O. Tellingen, J. Beijnen, H. Dekker, C. Paulusma, R. Elferink, F. Baas, P. Borst (1995)
Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.Proceedings of the National Academy of Sciences of the United States of America, 92 17
E. Schneider, H. Yamazaki, B. Sinha, K. Cowan (1995)
Buthionine sulphoximine-mediated sensitisation of etoposide-resistant human breast cancer MCF7 cells overexpressing the multidrug resistance-associated protein involves increased drug accumulation.British Journal of Cancer, 71
A. Shapiro, V. Ling (1997)
Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities.European journal of biochemistry, 250 1
G. Rappa, A. Lorico, R. Flavell, A. Sartorelli (1997)
Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins.Cancer research, 57 23
C. Higgins (1992)
ABC transporters: from microorganisms to man.Annual review of cell biology, 8
Lee (2000)
Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cellsJ. Natl. Cancer Inst., 92
David Miller, S. Nobmann, H. Gutmann, Michael Toeroek, J. Drewe, G. Fricker (2000)
Xenobiotic transport across isolated brain microvessels studied by confocal microscopy.Molecular pharmacology, 58 6
Alexander Smith, U. Mayer, A. Schinkel, P. Borst (1998)
Availability of PSC833, a Substrate and Inhibitor of P-glycoproteins, in Various Concentrations of SerumJournal of the National Cancer Institute, 90
C. Slapak, N. Mizunuma, D. Kufe (1994)
Expression of the multidrug resistance associated protein and P-glycoprotein in doxorubicin-selected human myeloid leukemia cells.Blood, 84 9
Smith (1998)
Availability of PSC833, a substrate and inhibitor of P-glycoproteins, in various concentrations of serumJ. Natl. Cancer Inst., 90
(2001)
Structure of MsbA from E. coli: A Homolog of the Multidrug Resistance ATP Binding Cassette (ABC) Transporters
P. Mistry, A. Stewart, Wendy Dangerfield, S. Okiji, C. Liddle, D. Bootle, J. Plumb, D. Templeton, P. Charlton (2001)
In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576.Cancer research, 61 2
Zhang (2001)
Identification of a nonconserved amino acid residue in multidrug resistance protein 1 important for determining substrate specificity: evidence for functional interaction between transmembrane helices 14 and 17J. Biol. Chem., 276
J. Wijnholds, R. Evers, M. Leusden, C. Mol, G. Zaman, U. Mayer, J. Beijnen, M. Valk, P. Krimpenfort, P. Borst (1997)
Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated proteinNature Medicine, 3
R. Evers, M. Haas, R. Sparidans, J. Beijnen, Pieter Wielinga, Jan Lankelma, Piet Borst (2000)
Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione exportBritish Journal of Cancer, 83
I. Sugawara, Iyo Kataoka, Y. Morishita, H. Hamada, T. Tsuruo, S. Itoyama, S. Mori (1988)
Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16.Cancer research, 48 7
C. Higgins, M. Gottesman (1992)
Is the multidrug transporter a flippase?Trends in biochemical sciences, 17 1
E. Schuetz, D. Umbenhauer, K. Yasuda, C. Brimer, L. Nguyen, M. Relling, J. Schuetz, A. Schinkel (2000)
Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes.Molecular pharmacology, 57 1
A. Lorico, G. Rappa, R. Finch, Di Yang, Richard Flavell, Alan Sartorelli (1997)
Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione.Cancer research, 57 23
M. St-Pierre, M. Serrano, R. Macias, U. Dubs, M. Hoechli, U. Lauper, P. Meier, J. Marin (2000)
Expression of members of the multidrug resistance protein family in human term placenta.American journal of physiology. Regulatory, integrative and comparative physiology, 279 4
T. Litman, M. Brangi, E. Hudson, P. Fetsch, A. Abati, Douglas Ross, K. Miyake, J. Resau, S. Bates (2000)
The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2).Journal of cell science, 113 ( Pt 11)
G. Jedlitschky, B. Burchell, D. Keppler (2000)
The Multidrug Resistance Protein 5 Functions as an ATP-dependent Export Pump for Cyclic Nucleotides*The Journal of Biological Chemistry, 275
Ross (1999)
Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell linesJ. Natl. Cancer Inst., 91
G. Scheffer, M. Kool, M. Haas, J. Vree, A. Pijnenborg, D. Bosman, R. Elferink, P. Valk, P. Borst, R. Scheper (2002)
Tissue Distribution and Induction of Human Multidrug Resistant Protein 3Laboratory Investigation, 82
Thiebaut (1987)
Cellular localization of the multidrug resistance gene product in normal human tissuesProc. Natl. Acad. Sci. USA, 84
M. Newman, J. Rodarte, K. Benbatoul, S. Romano, Chengzhi Zhang, S. Krane, E. Moran, R. Uyeda, R. Dixon, E. Guns, L. Mayer (2000)
Discovery and characterization of OC144-093, a novel inhibitor of P-glycoprotein-mediated multidrug resistance.Cancer research, 60 11
Cordon-Cardo (1989)
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood?brain barrier sitesProc. Natl. Acad. Sci. USA, 86
M. Brangi, T. Litman, M. Ciotti, K. Nishiyama, G. Kohlhagen, C. Takimoto, R. Robey, Y. Pommier, T. Fojo, S. Bates (1999)
Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells.Cancer research, 59 23
K. Koike, T. Kawabe, Toshiya Tanaka, S. Toh, T. Uchiumi, M. Wada, S. Akiyama, M. Ono, M. Kuwano (1997)
A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells.Cancer research, 57 24
A. Dantzig, K. Law, Jin Cao, J. Starling (2001)
Reversal of multidrug resistance by the P-glycoprotein modulator, LY335979, from the bench to the clinic.Current medicinal chemistry, 8 1
T. Schaub, J. Kartenbeck, J. König, O. Vogel, R. Witzgall, W. Kriz, D. Keppler (1997)
Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules.Journal of the American Society of Nephrology : JASN, 8 8
Michael Müller, C. Meijer, G. Zaman, P. Borst, R. Scheper, N. Mulder, E. Vries, Peter Jansen (1994)
Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.Proceedings of the National Academy of Sciences of the United States of America, 91 26
He (1999)
Fumitremorgin C analogs that reverse mitoxantrone resistance in human colon carcinoma cellsMed. Chem. Res., 9
J. Allen, R. Brinkhuis, J. Wijnholds, A. Schinkel (1999)
The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin.Cancer research, 59 17
Loe (1996)
Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesiclesJ. Biol. Chem., 271
Müller (1994)
Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transportProc. Natl. Acad. Sci. USA, 91
Zaman (1994)
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pumpProc. Natl. Acad. Sci. USA, 91
A. Ayrton, P. Morgan (2001)
Role of transport proteins in drug absorption, distribution and excretionXenobiotica, 31
J. Hu, H.-P. Sun, C. Niu, H. Yan, T. Yu, Guo-Qiang Chen, Z-X Shen, Sj Chen, Zhen-yi Wang, Zhu Chen (2001)
Treatment of Acute Promyelocytic Leukemia with Arsenic Trioxide
A. Lorico, G. Rappa, R. Flavell, A. Sartorelli (1996)
Double knockout of the MRP gene leads to increased drug sensitivity in vitro.Cancer research, 56 23
Kool (1997)
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologs of the multidrug resistance-associated resistance protein (MRP1), in human cancer cell linesCancer Res., 57
V. Wacher, Chi‐Yuan Wu, L. Benet (1995)
Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapyMolecular Carcinogenesis, 13
H. Komatani, H. Kotani, Y. Hara, Rinako Nakagawa, M. Matsumoto, H. Arakawa, S. Nishimura (2001)
Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure.Cancer research, 61 7
Y. Kiuchi, H. Suzuki, T. Hirohashi, C. Tyson, Y. Sugiyama (1998)
cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3) 1FEBS Letters, 433
M. McAleer, M. Breen, Nina White, N. Matthews (1999)
pABC11 (Also Known as MOAT-C and MRP5), a Member of the ABC Family of Proteins, Has Anion Transporter Activity but Does Not Confer Multidrug Resistance When Overexpressed in Human Embryonic Kidney 293 Cells*The Journal of Biological Chemistry, 274
K. Miyake, L. Mickley, T. Litman, Z. Zhan, R. Robey, Barbara Cristensen, M. Brangi, L. Greenberger, Michael Dean, T. Fojo, S. Bates (1999)
Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes.Cancer research, 59 1
S. Kawabata, M. Oka, Ken Shiozawa, K. Tsukamoto, K. Nakatomi, H. Soda, M. Fukuda, Y. Ikegami, K. Sugahara, Yasuaki Yamada, S. Kamihira, L. Doyle, Douglas Ross, S. Kohno (2001)
Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells.Biochemical and biophysical research communications, 280 5
Douglas Ross, Weidong Yang, L. Abruzzo, W. Dalton, E. Schneider, H. Lage, M. Dietel, L. Greenberger, S. Cole, L. Doyle (1999)
Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines.Journal of the National Cancer Institute, 91 5
G. Lankas, L. Wise, M. Cartwright, T. Pippert, D. Umbenhauer (1998)
Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice.Reproductive toxicology, 12 4
J. König, D. Rost, Yunhai Cui, D. Keppler (1999)
Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membraneHepatology, 29
A. Sparreboom, J. Asperen, U. Mayer, A. Schinkel, J. Smit, D. Meijer, P. Borst, W. Nooijen, J. Beijnen, O. Tellingen (1997)
Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine.Proceedings of the National Academy of Sciences of the United States of America, 94 5
S. Ambudkar, S. Dey, C. Hrycyna, M. Ramachandra, I. Pastan, M. Gottesman (1999)
Biochemical, cellular, and pharmacological aspects of the multidrug transporter.Annual review of pharmacology and toxicology, 39
T. Hirohashi, H. Suzuki, Yuichi Sugiyama (1999)
Characterization of the Transport Properties of Cloned Rat Multidrug Resistance-associated Protein 3 (MRP3)*The Journal of Biological Chemistry, 274
Sheng Zhou, J. Schuetz, K. Bunting, A. Colapietro, J. Sampath, J. Morris, I. Lagutina, G. Grosveld, M. Osawa, H. Nakauchi, B. Sorrentino (2001)
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotypeNature Medicine, 7
M. Malingré, J. Terwogt, J. Beijnen, H. Rosing, F. Koopman, O. Tellingen, K. Duchin, W. Huinink, M. Swart, J. Lieverst, J. Schellens (2000)
Phase I and pharmacokinetic study of oral paclitaxel.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 18 12
Jie Dai, R. Weinberg, S. Waxman, Y. Jing (1999)
Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system.Blood, 93 1
J. Jonker, J. Smit, R. Brinkhuis, M. Maliepaard, J. Beijnen, J. Schellens, A. Schinkel (2000)
Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan.Journal of the National Cancer Institute, 92 20
M. Maliepaard, G. Scheffer, I. Faneyte, M. Gastelen, A. Pijnenborg, A. Schinkel, M. Vijver, R. Scheper, J. Schellens (2001)
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.Cancer research, 61 8
N. Zelcer, T. Saeki, G. Reid, J. Beijnen, P. Borst (2001)
Characterization of Drug Transport by the Human Multidrug Resistance Protein 3 (ABCC3)*The Journal of Biological Chemistry, 276
J. Smit, A. Schinkel, R. Elferink, A. Groen, E. Wagenaar, L. Deemter, C. Mol, R. Ottenhoff, N. Lugt, M. Roon, M. Valk, G. Offerhaus, A. Berns, P. Borst (1993)
Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver diseaseCell, 75
H. Veen, A. Margolles, Michael Müller, C. Higgins, W. Konings (2000)
The homodimeric ATP‐binding cassette transporter LmrA mediates multidrug transport by an alternating two‐site (two‐cylinder engine) mechanismThe EMBO Journal, 19
Borst (2000)
A family of drug transporters: the multidrug resistance-associated proteinsJ. Natl. Cancer Inst., 92
Scheffer (2002)
Tissue distribution and induction of human MRP3Lab. Investigation, 82
M. Bruin, K. Miyake, T. Litman, R. Robey, S. Bates (1999)
Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR.Cancer letters, 146 2
G. Zaman, M. Flens, M. Leusden, M. Haas, H. Mülder, J. Lankelma, H. Pinedo, R. Scheper, F. Baas, H. Broxterman, P. Borst (1994)
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.Proceedings of the National Academy of Sciences of the United States of America, 91 19
Zhe-Sheng Chen, T. Kawabe, M. Ono, S. Aoki, T. Sumizawa, T. Furukawa, T. Uchiumi, M. Wada, M. Kuwano, S. Akiyama (1999)
Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter.Molecular pharmacology, 56 6
Kyunghee Choi, Chang-jie Chen, M. Kriegler, I. Roninson (1988)
An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) geneCell, 53
K. Lee, Andres Klein-Szanto, G. Kruh (2000)
Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells.Journal of the National Cancer Institute, 92 23
A. Schinkel, E. Wagenaar, C. Mol, L. Deemter (1996)
P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.The Journal of clinical investigation, 97 11
H. Zeng, Lisa Bain, M. Belinsky, G. Kruh (1999)
Expression of multidrug resistance protein-3 (multispecific organic anion transporter-D) in human embryonic kidney 293 cells confers resistance to anticancer agents.Cancer research, 59 23
Mi‐Hye Lee, Kangmo Lu, S. Hazard, Hongwei Yu, S. Shulenin, H. Hidaka, H. Kojima, R. Allikmets, N. Sakuma, R. Pegoraro, A. Srivastava, G. Salen, M. Dean, Shailendra Patel (2001)
Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorptionNature Genetics, 27
Jonker (2000)
Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecanJ. Natl. Cancer Inst., 92
Ken-ichi Ito, C. Oleschuk, Chris Westlake, M. Vasa, R. Deeley, S. Cole (2001)
Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity.The Journal of biological chemistry, 276 41
L. Doyle, Weidong Yang, L. Abruzzo, T. Krogmann, Y. Gao, A. Rishi, Douglas Ross (1998)
A multidrug resistance transporter from human MCF-7 breast cancer cells.Proceedings of the National Academy of Sciences of the United States of America, 95 26
J. Asperen, O. Tellingen, A. Sparreboom, A. Schinkel, P. Borst, W. Nooijen, J. Beijnen (1997)
Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.British Journal of Cancer, 76
Holló (1996)
Transport properties of the multidrug resistance protein (MRP) in human tumour cellsFEBS Lett., 383
Advanced Drug Delivery Reviews – Pubmed
Published: Aug 29, 2003
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