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ABC Transporters: From Microorganisms to Man

ABC Transporters: From Microorganisms to Man All cells and subcellular compartments are separated from the external milieu by lipid membranes. Cell survival requires the regulated and selective passage 0743--4634/92/ 1 115-0067$02.00 HIGGINS of specific molecules across these membranes, not only to acquire nutrients and excrete waste products, but also for a multitude of regulatory and other functions. The importance of membrane transport to the cell is exemplified by the fact that almost with transport functions (Bachmann 20% of the E. coli genes so far identified are associated 1990). Transmembrane transport is mediated by specific proteins associated with the membrane. The character­ ization of these proteins and their roles in cellular physiology have been a focus of intensive research for many years. It is now apparent that these myriad membrane transport systems can be grouped into a limited number of families. Within any one family, members are related to each other in sequence and molecular mechanisms and probably have a common evolutionary origin. This review considers the largest and most diverse of these families, the ABC superfamily. ABC transporters have received considerable attention recently because they are associated with many important biological processes in both prokaryotes and eukaryotes, as well as with clinical problems such http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Cell and Developmental Biology Annual Reviews

ABC Transporters: From Microorganisms to Man

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Publisher
Annual Reviews
Copyright
Copyright 1992 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
1081-0706
eISSN
1530-8995
DOI
10.1146/annurev.cb.08.110192.000435
pmid
1282354
Publisher site
See Article on Publisher Site

Abstract

All cells and subcellular compartments are separated from the external milieu by lipid membranes. Cell survival requires the regulated and selective passage 0743--4634/92/ 1 115-0067$02.00 HIGGINS of specific molecules across these membranes, not only to acquire nutrients and excrete waste products, but also for a multitude of regulatory and other functions. The importance of membrane transport to the cell is exemplified by the fact that almost with transport functions (Bachmann 20% of the E. coli genes so far identified are associated 1990). Transmembrane transport is mediated by specific proteins associated with the membrane. The character­ ization of these proteins and their roles in cellular physiology have been a focus of intensive research for many years. It is now apparent that these myriad membrane transport systems can be grouped into a limited number of families. Within any one family, members are related to each other in sequence and molecular mechanisms and probably have a common evolutionary origin. This review considers the largest and most diverse of these families, the ABC superfamily. ABC transporters have received considerable attention recently because they are associated with many important biological processes in both prokaryotes and eukaryotes, as well as with clinical problems such

Journal

Annual Review of Cell and Developmental Biology – Annual Reviews

Published: Nov 1, 1992

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