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Transcriptional Regulation of the GluR2 Gene: Neural-Specific Expression, Multiple Promoters, and Regulatory Elements

Transcriptional Regulation of the GluR2 Gene: Neural-Specific Expression, Multiple Promoters, and... The Journal of Neuroscience, September 1, 1998, 18(17):6723–6739 Transcriptional Regulation of the GluR2 Gene: Neural-Specific Expression, Multiple Promoters, and Regulatory Elements 1,2 1 1 2 3 Scott J. Myers, Jeanne Peters, Yunfei Huang, Mary B. Comer, Fabrice Barthel, and Raymond Dingledine 1 2 Department of Pharmacology, Emory University, Atlanta, Georgia 30322, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, U 259 INSERM, Universite de Bordeaux II, 33077 Bordeaux Cedex, France To understand how neurons control the expression of the AMPA (NRF-1) elements within a GC-rich proximal GluR2 promoter receptor subunit GluR2, we cloned the 59 proximal region of the region. The GluR2 silencer reduced promoter activity in glia and rat gene and investigated GluR2 promoter activity by transient non-neuronal cell lines by two- to threefold, was without effect transfection. RNase protection and primer extension of rat brain in cortical neurons, and could bind the RE1-silencing transcrip- mRNA revealed multiple transcription initiation sites from 2340 tion factor (REST) because cotransfection of REST into neurons to 2481 bases upstream of the GluR2 AUG codon. The relative reduced GluR2 promoter activity in a silencer-dependent man- use of 59 start sites was different in cortex and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neuroscience Unpaywall

Transcriptional Regulation of the GluR2 Gene: Neural-Specific Expression, Multiple Promoters, and Regulatory Elements

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Publisher
Unpaywall
ISSN
0270-6474
DOI
10.1523/jneurosci.18-17-06723.1998
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Abstract

The Journal of Neuroscience, September 1, 1998, 18(17):6723–6739 Transcriptional Regulation of the GluR2 Gene: Neural-Specific Expression, Multiple Promoters, and Regulatory Elements 1,2 1 1 2 3 Scott J. Myers, Jeanne Peters, Yunfei Huang, Mary B. Comer, Fabrice Barthel, and Raymond Dingledine 1 2 Department of Pharmacology, Emory University, Atlanta, Georgia 30322, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, U 259 INSERM, Universite de Bordeaux II, 33077 Bordeaux Cedex, France To understand how neurons control the expression of the AMPA (NRF-1) elements within a GC-rich proximal GluR2 promoter receptor subunit GluR2, we cloned the 59 proximal region of the region. The GluR2 silencer reduced promoter activity in glia and rat gene and investigated GluR2 promoter activity by transient non-neuronal cell lines by two- to threefold, was without effect transfection. RNase protection and primer extension of rat brain in cortical neurons, and could bind the RE1-silencing transcrip- mRNA revealed multiple transcription initiation sites from 2340 tion factor (REST) because cotransfection of REST into neurons to 2481 bases upstream of the GluR2 AUG codon. The relative reduced GluR2 promoter activity in a silencer-dependent man- use of 59 start sites was different in cortex and

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Journal of Neuroscience – Unpaywall

Published: Sep 1, 1998

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