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Cellular Mechanisms of Immunologic Tolerance

Cellular Mechanisms of Immunologic Tolerance Immunologic tolerance, the phenomenon whereby antigen interacts with the lymphoid system to impair its later capacity to respond to that antigen, remains one of the most fascinating problems in cellular immunology. The capacity of individuals to discriminate "self" from "not self" has assumed a new dimension since the realization that T lymphocytes only see foreign antigens in the context of "self" molecules of the major histocompatibility complex (MHC) (131), and so the newer field of MHC restriction has become intertwined with immunologic tolerance and indeed with all aspects of immunoregulation. Although the central interest of students of im­ munologic tolerance lies in the establishment and maintenance of self­ recognition, experimental realities mandate that most work on tolerance in fact is performed with model systems where foreign antigens, rather than autologous constituents, are presented to the lymphoid system to induce a state of non-reactivity. It then becomes a matter of considerable difficulty to judge whether the effects observed mimic the physiological situation of lymphocytes coming to grips with the need to avoid horror aulotoxicus, or whether the model illustrates some facet of immunoregulation needed to limit the cascade of immunoproliferation that follows the introduction of antigen. Faced with this http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Cellular Mechanisms of Immunologic Tolerance

Nossal, G J V
Annual Review of Immunology , Volume 1 (1) – Apr 1, 1983
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Publisher
Annual Reviews
Copyright
Copyright 1983 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.01.040183.000341
pmid
6399977
Publisher site
See Article on Publisher Site

Abstract

Immunologic tolerance, the phenomenon whereby antigen interacts with the lymphoid system to impair its later capacity to respond to that antigen, remains one of the most fascinating problems in cellular immunology. The capacity of individuals to discriminate "self" from "not self" has assumed a new dimension since the realization that T lymphocytes only see foreign antigens in the context of "self" molecules of the major histocompatibility complex (MHC) (131), and so the newer field of MHC restriction has become intertwined with immunologic tolerance and indeed with all aspects of immunoregulation. Although the central interest of students of im­ munologic tolerance lies in the establishment and maintenance of self­ recognition, experimental realities mandate that most work on tolerance in fact is performed with model systems where foreign antigens, rather than autologous constituents, are presented to the lymphoid system to induce a state of non-reactivity. It then becomes a matter of considerable difficulty to judge whether the effects observed mimic the physiological situation of lymphocytes coming to grips with the need to avoid horror aulotoxicus, or whether the model illustrates some facet of immunoregulation needed to limit the cascade of immunoproliferation that follows the introduction of antigen. Faced with this

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1983

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