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Inhibition by Atractyloside of the Binding of Adenine-nucleotides to Rat-liver Mitochondria

Inhibition by Atractyloside of the Binding of Adenine-nucleotides to Rat-liver Mitochondria IT has been shown1–3 that atractyloside, like oligomycin4, acts as inhibitor of oxidative phosphorylation by a specific interference with energy-transfer reactions. The competition between atractyloside and ADP on oxygen and phosphate uptake by mitochondria3 would seem to indicate that the effect of atractyloside is due to inhibition of the ADP utilizing process in the coupling system. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Inhibition by Atractyloside of the Binding of Adenine-nucleotides to Rat-liver Mitochondria

BRUNI, A.; LUCIANI, S.; CONTESSA, A. R.
Nature , Volume 201 (4925) – Mar 21, 1964
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References (8)

Publisher
Springer Journals
Copyright
Copyright © 1964 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/2011219a0
Publisher site
See Article on Publisher Site

Abstract

IT has been shown1–3 that atractyloside, like oligomycin4, acts as inhibitor of oxidative phosphorylation by a specific interference with energy-transfer reactions. The competition between atractyloside and ADP on oxygen and phosphate uptake by mitochondria3 would seem to indicate that the effect of atractyloside is due to inhibition of the ADP utilizing process in the coupling system.

Journal

Nature – Springer Journals

Published: Mar 21, 1964

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